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COMBPDCHEMOTHERAPY

Rational design of combined PDT photosensitizers and chemotherapeutic agent as new approach in cancer therapy: a computational approach

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COMBPDCHEMOTHERAPY project word cloud

Explore the words cloud of the COMBPDCHEMOTHERAPY project. It provides you a very rough idea of what is the project "COMBPDCHEMOTHERAPY" about.

thorough    laser    photochemical    complexes    actions    chemical    ascribed    time    photocleaving    planning    effect    orienting    class    wavelength    efficiency    tumour    techniques    maintaining    restrictions    induces    profiles    researcher    absorber    predicted    irradiation    priori    members    first    platinum    consisting    absorbing    620    cytostatic    types    window    cisplatin    experiments    photosensitizers    entire    combine    consuming    synthesis    body    850    modern    sensitizer    avoiding    dna    source    tests    chromophore    requirement    characterisation    photosensitising    variety    expensive    multitude    nm    experimental    treatment    therapeutic    conjugates    vitro    combination    series    bioactive    interesting    scientific    proceeding    innovative    theoretical    agents    apoptosis    principles    efficient    candidate    attempts    photodynamic    cells    moiety    pt    computational    necrosis    pdt    competences    anti    cancer    light    vivo    binding    molecular    dark    gained    invasive    ps    molecules    action    appropriate    physical    drug    basic    therapy    oxygen    accurately   

Project "COMBPDCHEMOTHERAPY" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://www.quanthic.fr
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS FR (PARIS CEDEX 05) coordinator 173˙076.00
2    ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS FR (PARIS) coordinator 0.00

Map

 Project objective

The present proposal aims to enhance the competences, the scientific and innovative potential of the experienced researcher in the field of the emerging non-invasive treatment of a variety of cancer tumour types called photodynamic therapy (PDT). This approach induces tumour cells necrosis and/or apoptosis by a combination of a photosensitising drug (PS) capable of absorbing within the body’s therapeutic window (620–850 nm), a light source (e.g.,a laser) of an appropriate wavelength and molecular oxygen. To further advance the novel PDT treatment, the design, synthesis and characterisation of new photosensitizers with improved efficiency and side effect profiles is needed, together with a more thorough and integrated understanding of the multitude of targets/actions so far ascribed to PDT. In this field, the information that can be gained from modern theoretical methods is very useful, since several crucial chemical and physical properties of candidate photosensitizers can be accurately predicted from first principles by various computational techniques, contributing to increase the understanding of the entire photochemical pathways involved. The “a priori” knowledge of a series of properties can be considered a basic requirement before proceeding to the synthesis, chemical-physical characterisation and in vitro and in vivo tests, thus orienting experimental planning and avoiding expensive and time-consuming experiments. The project attempts to investigate members of a novel and very interesting class of bioactive molecules of interest as anti-cancer agents, consisting of a light-absorber chromophore (PS) and a cisplatin-like unit. The two-component conjugates combine the cytostatic activity of the platinum moiety in the dark, and upon irradiation, the photodynamic action of the sensitizer. Such systems could address the restrictions of Pt-based complexes and provide a target for PDT agents, while maintaining efficient DNA binding and photocleaving properties.

 Publications

year authors and title journal last update
List of publications.
2016 Marta Erminia Alberto, Jenny Pirillo, Nino Russo, Carlo Adamo
Theoretical Exploration of Type I/Type II Dual Photoreactivity of Promising Ru(II) Dyads for PDT Approach
published pages: 11185-11192, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.6b01782
Inorganic Chemistry 55/21 2019-07-23
2016 Marta E. Alberto, Nino Russo, Carlo Adamo
Synergistic Effects of Metals in a Promising Ru II −Pt II Assembly for a Combined Anticancer Approach: Theoretical Exploration of the Photophysical Properties
published pages: 9162-9168, ISSN: 0947-6539, DOI: 10.1002/chem.201601089
Chemistry - A European Journal 22/27 2019-07-23
2017 Marta Erminia Alberto, Carlo Adamo
Synergistic effects in Pt(II)-Porphyrinoid Dyes as candidates for a dual anticancer approach: a theoretical exploration
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201702876
Chemistry - A European Journal 2019-07-23
2016 Marta E. Alberto, Clara Comuzzi, Merlyn Thandu, Carlo Adamo, Nino Russo
22Ï€-Electrons [1.1.1.1.1] pentaphyrin as a new photosensitizing agent for water disinfection: experimental and theoretical characterization
published pages: , ISSN: 1432-881X, DOI: 10.1007/s00214-015-1794-4
Theoretical Chemistry Accounts 135/2 2019-07-23
2016 Gloria Mazzone, Marta Alberto, Bruna De Simone, Tiziana Marino, Nino Russo
Can Expanded Bacteriochlorins Act as Photosensitizers in Photodynamic Therapy? Good News from Density Functional Theory Computations
published pages: 288, ISSN: 1420-3049, DOI: 10.3390/molecules21030288
Molecules 21/3 2019-07-23

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The information about "COMBPDCHEMOTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

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