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COMBPDCHEMOTHERAPY

Rational design of combined PDT photosensitizers and chemotherapeutic agent as new approach in cancer therapy: a computational approach

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COMBPDCHEMOTHERAPY project word cloud

Explore the words cloud of the COMBPDCHEMOTHERAPY project. It provides you a very rough idea of what is the project "COMBPDCHEMOTHERAPY" about.

types    pt    sensitizer    attempts    cancer    experimental    photocleaving    maintaining    orienting    basic    actions    cytostatic    appropriate    body    multitude    therapy    predicted    bioactive    efficiency    accurately    computational    combination    cells    planning    priori    members    avoiding    chemical    platinum    cisplatin    window    light    850    nm    laser    time    tumour    first    source    principles    induces    apoptosis    necrosis    restrictions    anti    620    conjugates    effect    experiments    researcher    characterisation    thorough    proceeding    tests    photochemical    photodynamic    molecular    innovative    variety    candidate    entire    synthesis    combine    dna    expensive    pdt    series    techniques    drug    competences    profiles    photosensitising    irradiation    therapeutic    class    chromophore    consisting    theoretical    complexes    treatment    absorber    photosensitizers    action    interesting    scientific    agents    absorbing    ps    requirement    moiety    molecules    ascribed    dark    binding    modern    wavelength    vitro    consuming    invasive    oxygen    gained    vivo    physical    efficient   

Project "COMBPDCHEMOTHERAPY" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://www.quanthic.fr
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS FR (PARIS CEDEX 05) coordinator 173˙076.00
2    ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS FR (PARIS) coordinator 0.00

Map

 Project objective

The present proposal aims to enhance the competences, the scientific and innovative potential of the experienced researcher in the field of the emerging non-invasive treatment of a variety of cancer tumour types called photodynamic therapy (PDT). This approach induces tumour cells necrosis and/or apoptosis by a combination of a photosensitising drug (PS) capable of absorbing within the body’s therapeutic window (620–850 nm), a light source (e.g.,a laser) of an appropriate wavelength and molecular oxygen. To further advance the novel PDT treatment, the design, synthesis and characterisation of new photosensitizers with improved efficiency and side effect profiles is needed, together with a more thorough and integrated understanding of the multitude of targets/actions so far ascribed to PDT. In this field, the information that can be gained from modern theoretical methods is very useful, since several crucial chemical and physical properties of candidate photosensitizers can be accurately predicted from first principles by various computational techniques, contributing to increase the understanding of the entire photochemical pathways involved. The “a priori” knowledge of a series of properties can be considered a basic requirement before proceeding to the synthesis, chemical-physical characterisation and in vitro and in vivo tests, thus orienting experimental planning and avoiding expensive and time-consuming experiments. The project attempts to investigate members of a novel and very interesting class of bioactive molecules of interest as anti-cancer agents, consisting of a light-absorber chromophore (PS) and a cisplatin-like unit. The two-component conjugates combine the cytostatic activity of the platinum moiety in the dark, and upon irradiation, the photodynamic action of the sensitizer. Such systems could address the restrictions of Pt-based complexes and provide a target for PDT agents, while maintaining efficient DNA binding and photocleaving properties.

 Publications

year authors and title journal last update
List of publications.
2016 Marta Erminia Alberto, Jenny Pirillo, Nino Russo, Carlo Adamo
Theoretical Exploration of Type I/Type II Dual Photoreactivity of Promising Ru(II) Dyads for PDT Approach
published pages: 11185-11192, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.6b01782
Inorganic Chemistry 55/21 2019-07-23
2016 Marta E. Alberto, Nino Russo, Carlo Adamo
Synergistic Effects of Metals in a Promising Ru II −Pt II Assembly for a Combined Anticancer Approach: Theoretical Exploration of the Photophysical Properties
published pages: 9162-9168, ISSN: 0947-6539, DOI: 10.1002/chem.201601089
Chemistry - A European Journal 22/27 2019-07-23
2017 Marta Erminia Alberto, Carlo Adamo
Synergistic effects in Pt(II)-Porphyrinoid Dyes as candidates for a dual anticancer approach: a theoretical exploration
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201702876
Chemistry - A European Journal 2019-07-23
2016 Marta E. Alberto, Clara Comuzzi, Merlyn Thandu, Carlo Adamo, Nino Russo
22Ï€-Electrons [1.1.1.1.1] pentaphyrin as a new photosensitizing agent for water disinfection: experimental and theoretical characterization
published pages: , ISSN: 1432-881X, DOI: 10.1007/s00214-015-1794-4
Theoretical Chemistry Accounts 135/2 2019-07-23
2016 Gloria Mazzone, Marta Alberto, Bruna De Simone, Tiziana Marino, Nino Russo
Can Expanded Bacteriochlorins Act as Photosensitizers in Photodynamic Therapy? Good News from Density Functional Theory Computations
published pages: 288, ISSN: 1420-3049, DOI: 10.3390/molecules21030288
Molecules 21/3 2019-07-23

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The information about "COMBPDCHEMOTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

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