Explore the words cloud of the COMBPDCHEMOTHERAPY project. It provides you a very rough idea of what is the project "COMBPDCHEMOTHERAPY" about.
The following table provides information about the project.
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS
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|Coordinator Country||France [FR]|
|Total cost||173˙076 €|
|EC max contribution||173˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-07-01 to 2017-06-30|
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|1||ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS||FR (PARIS CEDEX 05)||coordinator||173˙076.00|
|2||ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS||FR (PARIS)||coordinator||0.00|
The present proposal aims to enhance the competences, the scientific and innovative potential of the experienced researcher in the field of the emerging non-invasive treatment of a variety of cancer tumour types called photodynamic therapy (PDT). This approach induces tumour cells necrosis and/or apoptosis by a combination of a photosensitising drug (PS) capable of absorbing within the body’s therapeutic window (620–850 nm), a light source (e.g.,a laser) of an appropriate wavelength and molecular oxygen. To further advance the novel PDT treatment, the design, synthesis and characterisation of new photosensitizers with improved efficiency and side effect profiles is needed, together with a more thorough and integrated understanding of the multitude of targets/actions so far ascribed to PDT. In this field, the information that can be gained from modern theoretical methods is very useful, since several crucial chemical and physical properties of candidate photosensitizers can be accurately predicted from first principles by various computational techniques, contributing to increase the understanding of the entire photochemical pathways involved. The “a priori” knowledge of a series of properties can be considered a basic requirement before proceeding to the synthesis, chemical-physical characterisation and in vitro and in vivo tests, thus orienting experimental planning and avoiding expensive and time-consuming experiments. The project attempts to investigate members of a novel and very interesting class of bioactive molecules of interest as anti-cancer agents, consisting of a light-absorber chromophore (PS) and a cisplatin-like unit. The two-component conjugates combine the cytostatic activity of the platinum moiety in the dark, and upon irradiation, the photodynamic action of the sensitizer. Such systems could address the restrictions of Pt-based complexes and provide a target for PDT agents, while maintaining efficient DNA binding and photocleaving properties.
|year||authors and title||journal||last update|
Marta Erminia Alberto, Jenny Pirillo, Nino Russo, Carlo Adamo
Theoretical Exploration of Type I/Type II Dual Photoreactivity of Promising Ru(II) Dyads for PDT Approach
published pages: 11185-11192, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.6b01782
|Inorganic Chemistry 55/21||2019-07-23|
Marta E. Alberto, Nino Russo, Carlo Adamo
Synergistic Effects of Metals in a Promising Ru II âˆ’Pt II Assembly for a Combined Anticancer Approach: Theoretical Exploration of the Photophysical Properties
published pages: 9162-9168, ISSN: 0947-6539, DOI: 10.1002/chem.201601089
|Chemistry - A European Journal 22/27||2019-07-23|
Marta Erminia Alberto, Carlo Adamo
Synergistic effects in Pt(II)-Porphyrinoid Dyes as candidates for a dual anticancer approach: a theoretical exploration
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201702876
|Chemistry - A European Journal||2019-07-23|
Marta E. Alberto, Clara Comuzzi, Merlyn Thandu, Carlo Adamo, Nino Russo
22Ï€-Electrons [126.96.36.199.1] pentaphyrin as a new photosensitizing agent for water disinfection: experimental and theoretical characterization
published pages: , ISSN: 1432-881X, DOI: 10.1007/s00214-015-1794-4
|Theoretical Chemistry Accounts 135/2||2019-07-23|
Gloria Mazzone, Marta Alberto, Bruna De Simone, Tiziana Marino, Nino Russo
Can Expanded Bacteriochlorins Act as Photosensitizers in Photodynamic Therapy? Good News from Density Functional Theory Computations
published pages: 288, ISSN: 1420-3049, DOI: 10.3390/molecules21030288
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