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COMBPDCHEMOTHERAPY

Rational design of combined PDT photosensitizers and chemotherapeutic agent as new approach in cancer therapy: a computational approach

Total Cost €

0

EC-Contrib. €

0

Partnership

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 COMBPDCHEMOTHERAPY project word cloud

Explore the words cloud of the COMBPDCHEMOTHERAPY project. It provides you a very rough idea of what is the project "COMBPDCHEMOTHERAPY" about.

combination    pdt    agents    consisting    experimental    experiments    chromophore    entire    competences    photocleaving    irradiation    restrictions    synthesis    dark    moiety    proceeding    binding    multitude    cells    effect    efficiency    maintaining    source    planning    treatment    complexes    computational    apoptosis    window    gained    therapy    nm    absorbing    action    body    series    orienting    oxygen    molecular    predicted    invasive    bioactive    620    attempts    chemical    actions    priori    induces    researcher    appropriate    combine    scientific    photodynamic    absorber    light    first    drug    techniques    ps    members    photosensitising    cancer    efficient    necrosis    850    time    principles    anti    types    interesting    tumour    ascribed    avoiding    laser    therapeutic    requirement    dna    vivo    variety    thorough    profiles    cytostatic    photochemical    sensitizer    wavelength    platinum    cisplatin    candidate    basic    expensive    accurately    class    tests    modern    innovative    consuming    theoretical    photosensitizers    conjugates    pt    physical    molecules    vitro    characterisation   

Project "COMBPDCHEMOTHERAPY" data sheet

The following table provides information about the project.

Coordinator
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://www.quanthic.fr
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS FR (PARIS CEDEX 05) coordinator 173˙076.00
2    ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS FR (PARIS) coordinator 0.00

Map

 Project objective

The present proposal aims to enhance the competences, the scientific and innovative potential of the experienced researcher in the field of the emerging non-invasive treatment of a variety of cancer tumour types called photodynamic therapy (PDT). This approach induces tumour cells necrosis and/or apoptosis by a combination of a photosensitising drug (PS) capable of absorbing within the body’s therapeutic window (620–850 nm), a light source (e.g.,a laser) of an appropriate wavelength and molecular oxygen. To further advance the novel PDT treatment, the design, synthesis and characterisation of new photosensitizers with improved efficiency and side effect profiles is needed, together with a more thorough and integrated understanding of the multitude of targets/actions so far ascribed to PDT. In this field, the information that can be gained from modern theoretical methods is very useful, since several crucial chemical and physical properties of candidate photosensitizers can be accurately predicted from first principles by various computational techniques, contributing to increase the understanding of the entire photochemical pathways involved. The “a priori” knowledge of a series of properties can be considered a basic requirement before proceeding to the synthesis, chemical-physical characterisation and in vitro and in vivo tests, thus orienting experimental planning and avoiding expensive and time-consuming experiments. The project attempts to investigate members of a novel and very interesting class of bioactive molecules of interest as anti-cancer agents, consisting of a light-absorber chromophore (PS) and a cisplatin-like unit. The two-component conjugates combine the cytostatic activity of the platinum moiety in the dark, and upon irradiation, the photodynamic action of the sensitizer. Such systems could address the restrictions of Pt-based complexes and provide a target for PDT agents, while maintaining efficient DNA binding and photocleaving properties.

 Publications

year authors and title journal last update
List of publications.
2016 Marta Erminia Alberto, Jenny Pirillo, Nino Russo, Carlo Adamo
Theoretical Exploration of Type I/Type II Dual Photoreactivity of Promising Ru(II) Dyads for PDT Approach
published pages: 11185-11192, ISSN: 0020-1669, DOI: 10.1021/acs.inorgchem.6b01782
Inorganic Chemistry 55/21 2019-07-23
2016 Marta E. Alberto, Nino Russo, Carlo Adamo
Synergistic Effects of Metals in a Promising Ru II −Pt II Assembly for a Combined Anticancer Approach: Theoretical Exploration of the Photophysical Properties
published pages: 9162-9168, ISSN: 0947-6539, DOI: 10.1002/chem.201601089
Chemistry - A European Journal 22/27 2019-07-23
2017 Marta Erminia Alberto, Carlo Adamo
Synergistic effects in Pt(II)-Porphyrinoid Dyes as candidates for a dual anticancer approach: a theoretical exploration
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201702876
Chemistry - A European Journal 2019-07-23
2016 Marta E. Alberto, Clara Comuzzi, Merlyn Thandu, Carlo Adamo, Nino Russo
22Ï€-Electrons [1.1.1.1.1] pentaphyrin as a new photosensitizing agent for water disinfection: experimental and theoretical characterization
published pages: , ISSN: 1432-881X, DOI: 10.1007/s00214-015-1794-4
Theoretical Chemistry Accounts 135/2 2019-07-23
2016 Gloria Mazzone, Marta Alberto, Bruna De Simone, Tiziana Marino, Nino Russo
Can Expanded Bacteriochlorins Act as Photosensitizers in Photodynamic Therapy? Good News from Density Functional Theory Computations
published pages: 288, ISSN: 1420-3049, DOI: 10.3390/molecules21030288
Molecules 21/3 2019-07-23

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The information about "COMBPDCHEMOTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

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