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KMET-READ

Reading of lysine methylation – discovery, biological function and application

Total Cost €

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EC-Contrib. €

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Partnership

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 KMET-READ project word cloud

Explore the words cloud of the KMET-READ project. It provides you a very rough idea of what is the project "KMET-READ" about.

proteins    reading    circular    kmet    alter    discover    seq    gene    spectroscopy    lysine    peptide    protein    sustainable    scaffold    recognize    suv39h1    training    found    cd    yeast    biology    structure    plant    patented    histone    act    chromatin    modulates    phd    manifest    methylation    hybrid    excellent    homeodomains    biochemistry    microscopy    residues    crystallography    maximize    communication    molecular    mass    chances    collaborations    cds    dichroism    readers    market    methyltransferases    spectrometry    effect    chip    pulldowns    mammalian    techniques    skills    initiate    biological    biophysics    fluorescence    cells    induce    binding    interdisciplinary    suv39h2    environment    identification    bind    arrays    anisotropy    career    read    marks    shown    chromodomains    expression    efficient    international    human    mll3    assays    phds    mark    mll2    confocal    fellow    stability    domains    influence    solving    plans    methyltransferase   

Project "KMET-READ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET STUTTGART 

Organization address
address: KEPLERSTRASSE 7
city: STUTTGART
postcode: 70174
website: www.uni-stuttgart.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ibtb.uni-stuttgart.de/bc/forschung/eumc/index.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET STUTTGART DE (STUTTGART) coordinator 171˙460.00

Map

 Project objective

Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. Recently, it was also shown to influence the stability and activity of non-histone proteins. Lysine methylation marks manifest their biological effect via so-called ‘readers’ (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. Reading domains include Plant homeodomains (PHD) and Chromodomains (CD) found in many chromatin proteins. KMET-READ plans to investigate the biological role of these reading domains in essential histone lysine methyltransferases - PHDs in MLL2 and MLL3 and CDs in SUV39H1 and SUV39H2. The results obtained here will advance the understanding of chromatin changes in human cells. The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). Importantly, the KMET-READ project will also develop a yeast-3-hybrid method for the identification of new reading domains, which will allow to discover binding partners for just recently characterized new protein methylation marks. This novel method will be patented and introduced into market. All project partners will ensure an efficient dissemination and communication of the results of the KMET-READ project. The project will provide excellent training in research methods and other skills for the fellow that will strongly support her future career and initiate new and sustainable collaborations between the partners.

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The information about "KMET-READ" are provided by the European Opendata Portal: CORDIS opendata.

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