Opendata, web and dolomites

KMET-READ

Reading of lysine methylation – discovery, biological function and application

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 KMET-READ project word cloud

Explore the words cloud of the KMET-READ project. It provides you a very rough idea of what is the project "KMET-READ" about.

initiate    confocal    act    methyltransferases    solving    homeodomains    techniques    chromatin    methylation    peptide    mark    manifest    skills    arrays    market    marks    chip    international    seq    circular    readers    cells    suv39h1    phd    found    career    lysine    structure    efficient    hybrid    induce    biology    recognize    fluorescence    plant    biochemistry    binding    expression    plans    read    cds    modulates    excellent    suv39h2    human    effect    collaborations    alter    communication    spectroscopy    histone    dichroism    methyltransferase    scaffold    mll2    crystallography    proteins    kmet    chances    yeast    bind    shown    stability    anisotropy    spectrometry    training    patented    gene    microscopy    assays    maximize    fellow    biophysics    interdisciplinary    environment    identification    influence    protein    residues    sustainable    pulldowns    mass    mammalian    molecular    discover    cd    biological    mll3    chromodomains    reading    domains    phds   

Project "KMET-READ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET STUTTGART 

Organization address
address: KEPLERSTRASSE 7
city: STUTTGART
postcode: 70174
website: www.uni-stuttgart.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ibtb.uni-stuttgart.de/bc/forschung/eumc/index.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET STUTTGART DE (STUTTGART) coordinator 171˙460.00

Map

 Project objective

Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. Recently, it was also shown to influence the stability and activity of non-histone proteins. Lysine methylation marks manifest their biological effect via so-called ‘readers’ (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. Reading domains include Plant homeodomains (PHD) and Chromodomains (CD) found in many chromatin proteins. KMET-READ plans to investigate the biological role of these reading domains in essential histone lysine methyltransferases - PHDs in MLL2 and MLL3 and CDs in SUV39H1 and SUV39H2. The results obtained here will advance the understanding of chromatin changes in human cells. The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). Importantly, the KMET-READ project will also develop a yeast-3-hybrid method for the identification of new reading domains, which will allow to discover binding partners for just recently characterized new protein methylation marks. This novel method will be patented and introduced into market. All project partners will ensure an efficient dissemination and communication of the results of the KMET-READ project. The project will provide excellent training in research methods and other skills for the fellow that will strongly support her future career and initiate new and sustainable collaborations between the partners.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "KMET-READ" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "KMET-READ" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

GW (2019)

Analysing the heavy element factories of the Universe : photometric and spectroscopic sample study of kilonovae

Read More