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KMET-READ

Reading of lysine methylation – discovery, biological function and application

Total Cost €

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EC-Contrib. €

0

Partnership

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 KMET-READ project word cloud

Explore the words cloud of the KMET-READ project. It provides you a very rough idea of what is the project "KMET-READ" about.

chromatin    cds    chromodomains    residues    reading    lysine    seq    manifest    fellow    market    mll3    marks    recognize    biological    shown    cells    domains    mammalian    mll2    anisotropy    act    patented    collaborations    modulates    cd    protein    hybrid    solving    alter    chip    assays    expression    phds    histone    plans    found    peptide    effect    methylation    bind    excellent    plant    scaffold    spectrometry    arrays    chances    spectroscopy    methyltransferases    microscopy    yeast    efficient    mass    environment    confocal    kmet    biochemistry    induce    gene    sustainable    stability    discover    communication    influence    career    international    interdisciplinary    dichroism    maximize    training    phd    proteins    suv39h2    read    readers    human    identification    structure    biophysics    molecular    biology    pulldowns    suv39h1    techniques    skills    fluorescence    homeodomains    mark    crystallography    initiate    methyltransferase    circular    binding   

Project "KMET-READ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET STUTTGART 

Organization address
address: KEPLERSTRASSE 7
city: STUTTGART
postcode: 70174
website: www.uni-stuttgart.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ibtb.uni-stuttgart.de/bc/forschung/eumc/index.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET STUTTGART DE (STUTTGART) coordinator 171˙460.00

Map

 Project objective

Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. Recently, it was also shown to influence the stability and activity of non-histone proteins. Lysine methylation marks manifest their biological effect via so-called ‘readers’ (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. Reading domains include Plant homeodomains (PHD) and Chromodomains (CD) found in many chromatin proteins. KMET-READ plans to investigate the biological role of these reading domains in essential histone lysine methyltransferases - PHDs in MLL2 and MLL3 and CDs in SUV39H1 and SUV39H2. The results obtained here will advance the understanding of chromatin changes in human cells. The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). Importantly, the KMET-READ project will also develop a yeast-3-hybrid method for the identification of new reading domains, which will allow to discover binding partners for just recently characterized new protein methylation marks. This novel method will be patented and introduced into market. All project partners will ensure an efficient dissemination and communication of the results of the KMET-READ project. The project will provide excellent training in research methods and other skills for the fellow that will strongly support her future career and initiate new and sustainable collaborations between the partners.

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The information about "KMET-READ" are provided by the European Opendata Portal: CORDIS opendata.

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