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KMET-READ

Reading of lysine methylation – discovery, biological function and application

Total Cost €

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EC-Contrib. €

0

Partnership

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 KMET-READ project word cloud

Explore the words cloud of the KMET-READ project. It provides you a very rough idea of what is the project "KMET-READ" about.

confocal    human    histone    gene    lysine    communication    fluorescence    biochemistry    anisotropy    influence    training    manifest    scaffold    spectroscopy    chip    collaborations    mll3    residues    international    hybrid    methyltransferases    read    molecular    peptide    chances    pulldowns    interdisciplinary    spectrometry    phd    suv39h1    effect    patented    environment    kmet    cds    protein    biophysics    sustainable    methyltransferase    cd    skills    alter    recognize    plant    phds    biological    career    assays    identification    efficient    crystallography    binding    shown    stability    techniques    circular    market    suv39h2    act    homeodomains    chromodomains    chromatin    bind    structure    arrays    mll2    initiate    seq    mark    cells    reading    biology    fellow    excellent    solving    readers    maximize    yeast    mass    mammalian    marks    proteins    plans    modulates    induce    microscopy    found    domains    expression    dichroism    methylation    discover   

Project "KMET-READ" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET STUTTGART 

Organization address
address: KEPLERSTRASSE 7
city: STUTTGART
postcode: 70174
website: www.uni-stuttgart.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ibtb.uni-stuttgart.de/bc/forschung/eumc/index.html
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET STUTTGART DE (STUTTGART) coordinator 171˙460.00

Map

 Project objective

Protein methylation at lysine residues modulates chromatin structure, affects gene expression and mammalian development. Recently, it was also shown to influence the stability and activity of non-histone proteins. Lysine methylation marks manifest their biological effect via so-called ‘readers’ (or reading domains) which recognize and bind the methylation mark and directly alter the chromatin structure or act as a scaffold for other proteins, which induce biological responses. Reading domains include Plant homeodomains (PHD) and Chromodomains (CD) found in many chromatin proteins. KMET-READ plans to investigate the biological role of these reading domains in essential histone lysine methyltransferases - PHDs in MLL2 and MLL3 and CDs in SUV39H1 and SUV39H2. The results obtained here will advance the understanding of chromatin changes in human cells. The proposal will apply an interdisciplinary approach in an international environment to maximize its chances of success: the biological role of reading domains will be evaluated with molecular biology (histone and chromatin pulldowns, ChIP-seq, confocal microscopy), biochemistry (Peptide arrays, mass spectrometry, methyltransferase activity assays) and biophysics techniques (fluorescence anisotropy, circular dichroism spectroscopy) as well as crystallography (solving the structure of reading domains). Importantly, the KMET-READ project will also develop a yeast-3-hybrid method for the identification of new reading domains, which will allow to discover binding partners for just recently characterized new protein methylation marks. This novel method will be patented and introduced into market. All project partners will ensure an efficient dissemination and communication of the results of the KMET-READ project. The project will provide excellent training in research methods and other skills for the fellow that will strongly support her future career and initiate new and sustainable collaborations between the partners.

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The information about "KMET-READ" are provided by the European Opendata Portal: CORDIS opendata.

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