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LARP4MOT

Structural and functional studies of LARP4, a new RNA binding protein involved in mRNA stabilisation and cell migration

Total Cost €

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EC-Contrib. €

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Partnership

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Project "LARP4MOT" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.kcl.ac.uk/lsm/research/divisions/randall/research/sections/structural/conte/index.aspx
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

RNA-binding proteins (RBPs) act at multiple levels to regulate gene expression, including mRNA splicing, polyadenylation, localisation, stability, decay and translational efficiency and, although central to health and disease, much of this precise concerted regulation remains to be uncovered. The recently discovered LARP4 is an RBP that affects mRNA stability and binds to polyA as well as the polyA-binding protein (PABP). Intriguingly, LARP4 has recently been identified as a regulator of cell morphology and migration in an RNAi screen, but little is known about how control of gene expression at the translational level is coordinated during cell migration and invasion. Since aberrant cell migration contributes to the development of human diseases including cancer, chronic inflammation and atherosclerosis, LARP4 represents an excellent RBP to advance our understanding of key cellular mechanisms relating to mRNA processing and turnover. The overall aim of the project is to understand at a molecular level how LARP4 regulates mRNA translation and how this impacts on cell migration, especially in the context of cancer cell biology, using human prostate cancer cell lines as models. For this, a multidisciplinary approach combining biochemistry, biophysics, structural and cell biology will be used.

 Publications

year authors and title journal last update
List of publications.
2017 Richard J. Maraia, Sandy Mattijssen, Isabel Cruz-Gallardo, Maria R. Conte
The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives
published pages: e1430, ISSN: 1757-7004, DOI: 10.1002/wrna.1430
Wiley Interdisciplinary Reviews: RNA 8/6 2019-04-18
2019 Isabel Cruz-Gallardo, Luigi Martino, Roberta Trotta, Stefano De Tito, Geoff Kelly, R. Andrew Atkinson, Antonio Randazzo, Maria R. Conte
Resonance assignment of human LARP4A La module
published pages: , ISSN: 1874-2718, DOI: 10.1007/s12104-019-09871-4
Biomolecular NMR Assignments 2019-02-27
2019 Isabel Cruz-Gallardo, Luigi Martino, Geoff Kelly, R Andrew Atkinson, Roberta Trotta, Stefano De Tito, Pierre Coleman, Zainab Ahdash, Yifei Gu, Tam T T Bui, Maria R Conte
LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA
published pages: 4272-4291, ISSN: 0305-1048, DOI: 10.1093/nar/gkz144
Nucleic Acids Research 47/8 2019-09-13

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