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CRYTOCOP SIGNED

Coat assembly and membrane remodelling: understanding regulation of protein secretion

Total Cost €

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EC-Contrib. €

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Partnership

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 CRYTOCOP project word cloud

Explore the words cloud of the CRYTOCOP project. It provides you a very rough idea of what is the project "CRYTOCOP" about.

shapes    couple    spherical    cell    ill    synthesized    molecular    reconstitutions    mediates    uniquely    regulatory    accommodate    shape    placed    complexity    bound    bilayer    material    concentric    obtain    eukaryotic    trafficking    tubules    carriers    vitro    newly    assembles    functional    characterised    questions    cargoes    capture    vesicles    transport    structural    ranging    assembly    regulation    compartments    proteins    relationship    variety    flexibility    techniques    understand    coat    regulated    complete    exchange    characterise    tackle    chemical    these    membranes    perfectly    sizes    export    resolutions    cargo    er    identities    electron    layers    perspectives    protein    deformation    assembled    tomography    shed    fast    combination    lab    assemble    cryo    structures    manner    form    membrane    outstanding    complexes    architecture    light    forefront    copii    averaging    components    mediate    view    carry    subtomogram    functions    exemplified    vesicular    answer    interactions    cells   

Project "CRYTOCOP" data sheet

The following table provides information about the project.

Coordinator
BIRKBECK COLLEGE - UNIVERSITY OF LONDON 

Organization address
address: MALET STREET
city: LONDON
postcode: WC1E 7HX
website: www.bbk.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙175 €
 EC max contribution 1˙499˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) coordinator 1˙499˙175.00

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 Project objective

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view of the COPII coat assembled on membranes. Our research will answer outstanding questions in the membrane trafficking field and open new perspectives to tackle ill-characterised regulation systems.

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