Opendata, web and dolomites


Coat assembly and membrane remodelling: understanding regulation of protein secretion

Total Cost €


EC-Contrib. €






 CRYTOCOP project word cloud

Explore the words cloud of the CRYTOCOP project. It provides you a very rough idea of what is the project "CRYTOCOP" about.

accommodate    layers    tomography    variety    form    bound    subtomogram    lab    interactions    assembly    obtain    averaging    proteins    shapes    perspectives    chemical    architecture    spherical    mediate    resolutions    export    reconstitutions    compartments    assembled    flexibility    assemble    coat    complexes    characterised    shed    relationship    functions    carriers    identities    components    perfectly    ill    regulatory    outstanding    couple    complete    forefront    transport    membrane    bilayer    answer    material    shape    combination    view    regulation    cryo    fast    techniques    er    deformation    cargo    understand    electron    complexity    light    tubules    ranging    protein    mediates    manner    exchange    vitro    synthesized    molecular    carry    trafficking    concentric    placed    assembles    membranes    copii    cells    exemplified    cargoes    these    cell    vesicles    characterise    newly    sizes    structural    functional    eukaryotic    uniquely    vesicular    tackle    questions    capture    structures    regulated   

Project "CRYTOCOP" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 7HX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙175 €
 EC max contribution 1˙499˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view of the COPII coat assembled on membranes. Our research will answer outstanding questions in the membrane trafficking field and open new perspectives to tackle ill-characterised regulation systems.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CRYTOCOP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CRYTOCOP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

CohoSing (2019)

Cohomology and Singularities

Read More  


Co-production of seasonal representations for adaptive institutions

Read More  

EAST (2020)

Using Evolutionary Algorithms to Understand and Secure Web/Enterprise Systems

Read More