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CRYTOCOP SIGNED

Coat assembly and membrane remodelling: understanding regulation of protein secretion

Total Cost €

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EC-Contrib. €

0

Partnership

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 CRYTOCOP project word cloud

Explore the words cloud of the CRYTOCOP project. It provides you a very rough idea of what is the project "CRYTOCOP" about.

interactions    shape    functions    shapes    uniquely    functional    light    transport    concentric    assembled    fast    eukaryotic    bilayer    cargoes    regulated    molecular    perfectly    components    sizes    couple    complexes    exemplified    shed    synthesized    resolutions    lab    vesicles    flexibility    proteins    assembly    identities    chemical    relationship    cargo    structural    placed    export    mediate    form    architecture    electron    copii    carriers    layers    questions    view    membranes    understand    compartments    trafficking    regulatory    perspectives    tomography    cryo    ranging    exchange    assemble    spherical    bound    obtain    coat    regulation    manner    averaging    outstanding    vitro    vesicular    newly    carry    accommodate    er    cells    cell    tackle    tubules    deformation    assembles    material    complete    answer    characterise    complexity    these    variety    mediates    ill    capture    characterised    subtomogram    membrane    techniques    combination    forefront    reconstitutions    structures    protein   

Project "CRYTOCOP" data sheet

The following table provides information about the project.

Coordinator
BIRKBECK COLLEGE - UNIVERSITY OF LONDON 

Organization address
address: MALET STREET
city: LONDON
postcode: WC1E 7HX
website: www.bbk.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙175 €
 EC max contribution 1˙499˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) coordinator 1˙499˙175.00

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 Project objective

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view of the COPII coat assembled on membranes. Our research will answer outstanding questions in the membrane trafficking field and open new perspectives to tackle ill-characterised regulation systems.

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The information about "CRYTOCOP" are provided by the European Opendata Portal: CORDIS opendata.

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