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CRYTOCOP SIGNED

Coat assembly and membrane remodelling: understanding regulation of protein secretion

Total Cost €

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EC-Contrib. €

0

Partnership

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 CRYTOCOP project word cloud

Explore the words cloud of the CRYTOCOP project. It provides you a very rough idea of what is the project "CRYTOCOP" about.

combination    shape    protein    perfectly    cryo    coat    capture    characterised    subtomogram    couple    tubules    relationship    membrane    compartments    answer    mediate    vesicles    copii    identities    complexes    understand    spherical    outstanding    resolutions    questions    assembled    assembly    export    layers    obtain    electron    averaging    deformation    vesicular    light    accommodate    sizes    forefront    uniquely    synthesized    structures    complete    er    bilayer    variety    newly    functional    interactions    perspectives    chemical    bound    manner    eukaryotic    concentric    regulated    tackle    cell    vitro    carry    flexibility    components    proteins    membranes    tomography    structural    material    complexity    exemplified    form    shapes    transport    view    trafficking    lab    functions    reconstitutions    techniques    assembles    carriers    cargoes    placed    molecular    regulatory    assemble    cargo    mediates    characterise    cells    these    shed    ranging    ill    regulation    exchange    fast    architecture   

Project "CRYTOCOP" data sheet

The following table provides information about the project.

Coordinator
BIRKBECK COLLEGE - UNIVERSITY OF LONDON 

Organization address
address: MALET STREET
city: LONDON
postcode: WC1E 7HX
website: www.bbk.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙175 €
 EC max contribution 1˙499˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) coordinator 1˙499˙175.00

Map

 Project objective

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view of the COPII coat assembled on membranes. Our research will answer outstanding questions in the membrane trafficking field and open new perspectives to tackle ill-characterised regulation systems.

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