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CRYTOCOP SIGNED

Coat assembly and membrane remodelling: understanding regulation of protein secretion

Total Cost €

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EC-Contrib. €

0

Partnership

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 CRYTOCOP project word cloud

Explore the words cloud of the CRYTOCOP project. It provides you a very rough idea of what is the project "CRYTOCOP" about.

lab    mediates    architecture    exemplified    sizes    regulation    complexes    ranging    questions    membranes    functions    ill    carriers    complexity    fast    structural    eukaryotic    assembles    identities    cell    chemical    membrane    flexibility    shape    material    techniques    capture    couple    tackle    cargo    forefront    synthesized    outstanding    molecular    reconstitutions    placed    shed    complete    vesicles    subtomogram    interactions    shapes    mediate    perspectives    assembly    spherical    concentric    view    characterised    bound    er    tubules    combination    coat    accommodate    components    answer    structures    proteins    tomography    form    layers    export    carry    cells    characterise    protein    regulated    assembled    perfectly    regulatory    variety    vitro    trafficking    manner    newly    understand    averaging    assemble    obtain    functional    exchange    cryo    resolutions    uniquely    electron    vesicular    cargoes    relationship    copii    deformation    light    compartments    bilayer    these    transport   

Project "CRYTOCOP" data sheet

The following table provides information about the project.

Coordinator
BIRKBECK COLLEGE - UNIVERSITY OF LONDON 

Organization address
address: MALET STREET
city: LONDON
postcode: WC1E 7HX
website: www.bbk.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙175 €
 EC max contribution 1˙499˙175 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) coordinator 1˙499˙175.00

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 Project objective

Eukaryotic cells are organised in membrane-bound compartments, which have defined chemical identities and carry out specific essential functions. Exchange of material between these compartments is necessary to maintain cell functionality, and is achieved in a highly specific and regulated manner by vesicular transport. To mediate protein trafficking, coat complexes assemble on membranes and couple bilayer deformation with cargo capture into transport carriers. How coat assembly can deliver the flexibility necessary to accommodate a wide variety of cargo proteins, and how the process can be regulated, are outstanding questions in the field. This is exemplified by the COPII coat, which mediates export from the ER of about a third of newly synthesized proteins. COPII assembles into two concentric layers and can form transport carriers of a variety of shapes and sizes, including tubules and spherical vesicles. This is important for export of large cargoes and is a process targeted by cargo-specific regulatory factors. The aim of this project proposal is to shed light on the molecular interactions between coat components, and understand their role in determination of coat architecture and membrane shape. We will use a combination of structural and functional approaches to characterise COPII coat assembly, and its relationship with membranes in systems of increasing complexity, ranging from in vitro reconstitutions to cells. In particular, we will use cryo-electron tomography and subtomogram averaging to understand the architecture of the coat layers in these systems. These are fast-developing techniques that uniquely target complex structures while achieving high resolutions. With my lab at the forefront of current advances, we are perfectly placed to obtain a complete view of the COPII coat assembled on membranes. Our research will answer outstanding questions in the membrane trafficking field and open new perspectives to tackle ill-characterised regulation systems.

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