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NIBSAD

Electrophysiological markers of cognitive processes and neuroplasticity in healthy ageing and Alzheimer`s disease

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EC-Contrib. €

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Project "NIBSAD" data sheet

The following table provides information about the project.

Coordinator
PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI 

Organization address
address: VIA PILASTRONI 4
city: BRESCIA
postcode: 25125
website: http://www.irccs-fatebenefratelli.it/sito/pagine/fatebenefratelli.php

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://www.researchgate.net/profile/Jesus_Cespon
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI IT (BRESCIA) coordinator 180˙277.00

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 Project objective

Ageing of the European population is increasing prevalence of age-related diseases such as Alzheimer’s disease (AD). AD is considered a public health priority due to socio-economic costs and limited efficacy of current pharmacological treatments. Co-registration of electroencephalogram (EEG) and transcranial magnetic stimulation (TMS) is a novelty, non-expensive and non-invasive approach to obtain surrogate markers of cognitive decline. Moreover, repetitive TMS (rTMS) is considered a promising tool to induce neuroplasticity and improve cognitive functions. The main objective of this research is providing markers of brain activity, reactivity, connectivity and plasticity related with healthy and pathological ageing (i.e., early AD). Thus, samples of healthy young, healthy elderly and AD patients will perform a behavioural task (to study visuospatial attention and cognitive control processes) while carrying out EEG recording and online EEG/TMS co-registration. Correlates of brain activity (event-related brain potentials), reactivity (amplitude of TMS evoked potential -TEP) and connectivity (TEP topography, coherence, synchronization, and graph theoretical analysis of complex networks) will be obtained before and after of delivering offline rTMS. It will allow studying differences in cortical responses induced by rTMS on each group of participants, which will provide correlates and biomarkers of brain plasticity related with age and AD. These biomarkers will allow the identification of individuals at early stages of AD and evaluating efficacy of novel TMS treatments. Importantly, identification of rTMS parameters responsible to induce neural plasticity and improve cognitive functions will contribute to develop rehabilitation protocols for AD patients.

 Publications

year authors and title journal last update
List of publications.
2018 Jesús Cespón, Carlo Miniussi, Maria Concetta Pellicciari
Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity
published pages: , ISSN: 1568-1637, DOI:
Ageing Research Reviews 2019-06-17
2019 Jesús Cespón, Maria Concetta Pellicciari, Carlo Miniussi
Brain activity, excitability, and impaired performance in young and elderly subjects after rTMS
published pages: , ISSN: 0197-4580, DOI:
Neurobiology of Aging 2019-06-17
2017 Jesús Cespón, Claudia Rodella, Paolo M. Rossini, Carlo Miniussi, Maria C. Pellicciari
Anodal Transcranial Direct Current Stimulation Promotes Frontal Compensatory Mechanisms in Healthy Elderly Subjects
published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2017.00420
Frontiers in Aging Neuroscience 9 2019-06-17
2016 Jesús Cespón, Santiago Galdo-Álvarez, Fernando Díaz
Cognitive control activity is modulated by the magnitude of interference and pre-activation of monitoring mechanisms
published pages: 39595, ISSN: 2045-2322, DOI: 10.1038/srep39595
Scientific Reports 6 2019-06-17
2018 Jesús Cespón, Claudia Rodella, Carlo Miniussi, Maria Concetta Pellicciari
Promotion of frontal compensatory mechanisms in healthy elderly and Alzheimer’s disease patients involves the use of different tDCS polarity
published pages: , ISSN: 1388-2457, DOI:
Clinical Neurophysiology 2019-06-17

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