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AllergyBLOCK SIGNED

Blocking peanut allergy through protective IgG antibodies

Total Cost €

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EC-Contrib. €

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Partnership

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Project "AllergyBLOCK" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 161˙941.00
2    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 23˙134.00

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 Project objective

Food allergies are chronic diseases of increasing prevalence for which there is no approved treatment other than food allergen avoidance. Among all food allergies, peanut allergy is a particularly important public health problem since peanut allergy tends to persist throughout life and is more likely than other types of food allergies to cause severe shock (i.e., “anaphylaxis”) and death. The current paradigm states that peanut allergy is mostly triggered by IgE antibodies. Evidence derived from mouse models indicates that some IgG isotypes can also mediate allergic reactions, but the roles of human IgG in peanut allergy remain unknown.

Among the potential treatments for peanut allergy under investigation, oral immunotherapy (OIT) appears very promising since subjects completing OIT tolerate food challenges despite persistent high-titers of IgE in the blood. OIT consists of the administration of slowly increasing doses of the allergenic food and is associated with the production of large levels of IgG, but a direct link between these antibodies and the beneficial effects of OIT has not been demonstrated.

We hypothesize that peanut allergic patients produce both pro-allergic and protective IgG, and that successful OIT is associated with an increased production of protective IgG that are particularly potent at blocking the allergic reaction. We propose to test this hypothesis by developing and exploiting humanized mouse models of peanut allergy, combined with the use of clinical samples and purified IgG from peanut allergic patients completing a phase 2 OIT clinical trial. Finally, we aim at establishing the proof of concept that recombinant protective human IgG could be used to treat peanut allergy and improve the safety and efficiency of current OIT protocols.

 Publications

year authors and title journal last update
List of publications.
2017 Laurent L. Reber, Riccardo Sibilano, Philipp Starkl, Axel Roers, Michele A. Grimbaldeston, Mindy Tsai, Nicolas Gaudenzio, Stephen J. Galli
Imaging protective mast cells in living mice during severe contact hypersensitivity
published pages: online journal, ISSN: 2379-3708, DOI: 10.1172/jci.insight.92900
JCI Insight 2/9 2019-06-13
2017 Héloïse Beutier, Caitlin M. Gillis, Bruno Iannascoli, Ophélie Godon, Patrick England, Riccardo Sibilano, Laurent L. Reber, Stephen J. Galli, Mark S. Cragg, Nico Van Rooijen, David A. Mancardi, Pierre Bruhns, Friederike Jönsson
IgG subclasses determine pathways of anaphylaxis in mice
published pages: 269-280.e7, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2016.03.028
Journal of Allergy and Clinical Immunology 139/1 2019-06-13
2017 Laurent L. Reber, Caitlin M. Gillis, Philipp Starkl, Friederike Jönsson, Riccardo Sibilano, Thomas Marichal, Nicolas Gaudenzio, Marion Bérard, Stephan Rogalla, Christopher H. Contag, Pierre Bruhns, Stephen J. Galli
Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide
published pages: 1249-1258, ISSN: 0022-1007, DOI: 10.1084/jem.20161238
The Journal of Experimental Medicine 214/5 2019-06-13
2017 Laurent L. Reber, Joseph D. Hernandez, Stephen J. Galli
The pathophysiology of anaphylaxis
published pages: 335-348, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2017.06.003
Journal of Allergy and Clinical Immunology 140/2 2019-06-13
2017 Bianca Balbino, Riccardo Sibilano, Philipp Starkl, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L. Reber, Stephen J. Galli
Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis
published pages: 584-596.e10, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2016.05.047
Journal of Allergy and Clinical Immunology 139/2 2019-06-13

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