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METASPINE SIGNED

Comprehensive experimental and computational mechanical characterisation of metastatic vertebrae

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 METASPINE project word cloud

Explore the words cloud of the METASPINE project. It provides you a very rough idea of what is the project "METASPINE" about.

lesions    data    scoring    guidelines    validated    training    oncologists    spinal    host    mechanical    distributions    specialization    combination    musculoskeletal    bone    subject    quantitative    cancer    instability    clinical    surgeons    correlation    qualitative    axial    group    vertebrae    models    preparation    integrative    simulate    competence    accurate    profile    fellow    metastatic    palanca    computational    simultaneously    mechanistic    surgically    expertiments    experimental    organization    strain    fracture    time    laboratory    orthopaedic    tumour    understand    weaken    imaging    first    prediction    scenarios    metastases    patients    dall    university    middle    model    he    effect    bioengineer    reproduced    tested    finite    ara    metaspine    defects    sheffield    experimentally    decide    frequent    optimise    lytic    marco    skills    mentoring    risk    size    supervision    microct    volume    digital    complete    loading    displacement    spine    biomechanics    ct    situ    comprehensively    dr   

Project "METASPINE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 212˙933.00

Map

 Project objective

Lytic spinal metastases are frequent in cancer patients and can weaken vertebrae, increasing the risk of fracture and leading to spine instability. Qualitative scoring systems are used by oncologists and orthopaedic surgeons to decide if the metastatic vertebrae need to be surgically treated. However these guidelines are not accurate for all those patients with middle-size lesions. An accurate, quantitative and mechanistic computational model would improve the prediction of the risk of fracture in these patients. However, such models need first to be validated against well-controlled expertiments in the laboratory. METASPINE will deliver for the first time a method to comprehensively understand the effect of the properties of bone lesions on the mechanical competence of metastatic vertebrae. In this project, lytic defects will be experimentally reproduced in the vertebrae, which will be tested under multi-axial loading conditions in order to evaluate the effect of the lesions on the displacement and strain fields distributions. A combination of state of the art in situ mechanical testing, microCT imaging and Digital Volume Correlation will be used. Simultaneously, subject specific clinical CT based finite element models of the metastatic vertebrae will be generated, validated against the experimental data, and used to simulate scenarios which cannot be reproduced experimentally. The applicant (Dr Marco Palanca) is a research fellow in the field of experimental spine biomechanics. He will apply his experimental skills to optimise the sample preparation, and mechanical testing. Moreover, the supervision, mentoring, and training provided by the host organization (University of Sheffield, Dr Dall’Ara and Integrative Musculoskeletal Biomechanics group) on imaging and subject-specific finite element modelling will complete his profile as a bioengineer with a specialization in tumour and spine biomechanics.

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The information about "METASPINE" are provided by the European Opendata Portal: CORDIS opendata.

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