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METASPINE SIGNED

Comprehensive experimental and computational mechanical characterisation of metastatic vertebrae

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 METASPINE project word cloud

Explore the words cloud of the METASPINE project. It provides you a very rough idea of what is the project "METASPINE" about.

mechanical    microct    loading    supervision    integrative    middle    tested    frequent    accurate    profile    bone    tumour    training    university    competence    volume    simulate    expertiments    instability    lesions    orthopaedic    understand    model    musculoskeletal    oncologists    combination    data    distributions    palanca    experimentally    he    surgeons    preparation    complete    strain    axial    subject    time    displacement    effect    imaging    mentoring    group    metastatic    biomechanics    vertebrae    host    ara    sheffield    organization    finite    guidelines    correlation    metaspine    situ    marco    validated    weaken    skills    size    specialization    reproduced    qualitative    optimise    patients    mechanistic    comprehensively    dall    spinal    models    experimental    cancer    laboratory    lytic    bioengineer    defects    metastases    quantitative    surgically    risk    scenarios    fracture    fellow    digital    ct    first    scoring    clinical    spine    dr    simultaneously    prediction    decide    computational   

Project "METASPINE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 212˙933.00

Map

 Project objective

Lytic spinal metastases are frequent in cancer patients and can weaken vertebrae, increasing the risk of fracture and leading to spine instability. Qualitative scoring systems are used by oncologists and orthopaedic surgeons to decide if the metastatic vertebrae need to be surgically treated. However these guidelines are not accurate for all those patients with middle-size lesions. An accurate, quantitative and mechanistic computational model would improve the prediction of the risk of fracture in these patients. However, such models need first to be validated against well-controlled expertiments in the laboratory. METASPINE will deliver for the first time a method to comprehensively understand the effect of the properties of bone lesions on the mechanical competence of metastatic vertebrae. In this project, lytic defects will be experimentally reproduced in the vertebrae, which will be tested under multi-axial loading conditions in order to evaluate the effect of the lesions on the displacement and strain fields distributions. A combination of state of the art in situ mechanical testing, microCT imaging and Digital Volume Correlation will be used. Simultaneously, subject specific clinical CT based finite element models of the metastatic vertebrae will be generated, validated against the experimental data, and used to simulate scenarios which cannot be reproduced experimentally. The applicant (Dr Marco Palanca) is a research fellow in the field of experimental spine biomechanics. He will apply his experimental skills to optimise the sample preparation, and mechanical testing. Moreover, the supervision, mentoring, and training provided by the host organization (University of Sheffield, Dr Dall’Ara and Integrative Musculoskeletal Biomechanics group) on imaging and subject-specific finite element modelling will complete his profile as a bioengineer with a specialization in tumour and spine biomechanics.

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The information about "METASPINE" are provided by the European Opendata Portal: CORDIS opendata.

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