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mini-liver SCCS SIGNED

Human “mini-liver” stem cell culture systems: from mechanisms behind liver cancer origin and recurrence to new therapeutic treatments

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

mini-liver SCCS project word cloud

Explore the words cloud of the mini-liver SCCS project. It provides you a very rough idea of what is the project "mini-liver SCCS" about.

prevalent cellular therapeutic carcinoma limited cancer stem cell anti hcc mechanisms good molecular drive population strategies cancers lethal vitro 3d options liver pathogenesis models hepatocellular final physiologically human environmental elemental

Project "mini-liver SCCS" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.gurdon.cam.ac.uk/research/huch
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-04-20 to 2018-04-19

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. But at present, there are no good in vitro models for HCC. Thus, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive HCC pathogenesis and there are only limited therapeutic options. In this project, our aim is to establish and characterize physiologically relevant 3D-liver cancer stem cell models and use them to increase our understanding of the mechanisms behind liver cancer with the final goal to develop anti-cancer strategies.

Publications

List of publications.
year	authors and title	journal	last update
2017	Laura J.R. Broutier, Gianmarco Mastrogiovanni, Monique M.A. Verstegen, Hayley E. Francies, Lena Morrill GavarrÃ³, Charles R Bradshaw, George E Allen, Robert Arnes-Benito, Olga Sidorova, Marcia P. Gaspersz, Nikitas Georgakopoulos, Bon-Kyoung Koo, Sabine Dietmann, Susan E. Davies, Raaj K. Praseedom, Ruby Lieshout, Jan N. M. IJzermans, Stephen J. Wigmore, Kourosh Saeb-Parsy, Mathew J. Garnett, Luc J.W. van der Laan & Meritxell Huch Human primary liver cancerâ€“derived organoid cultures for disease modeling and drug screening published pages: 1424-1435, ISSN: 1078-8956, DOI: 10.17863/CAM.14402	Nature medicine 23	2019-06-13

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