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mini-liver SCCS SIGNED

Human “mini-liver” stem cell culture systems: from mechanisms behind liver cancer origin and recurrence to new therapeutic treatments

Total Cost €

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EC-Contrib. €

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Partnership

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Project "mini-liver SCCS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.gurdon.cam.ac.uk/research/huch
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-04-20   to  2018-04-19

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 183˙454.00

Map

 Project objective

Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. But at present, there are no good in vitro models for HCC. Thus, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive HCC pathogenesis and there are only limited therapeutic options. In this project, our aim is to establish and characterize physiologically relevant 3D-liver cancer stem cell models and use them to increase our understanding of the mechanisms behind liver cancer with the final goal to develop anti-cancer strategies.

 Publications

year authors and title journal last update
List of publications.
2017 Laura J.R. Broutier, Gianmarco Mastrogiovanni, Monique M.A. Verstegen, Hayley E. Francies, Lena Morrill Gavarró, Charles R Bradshaw, George E Allen, Robert Arnes-Benito, Olga Sidorova, Marcia P. Gaspersz, Nikitas Georgakopoulos, Bon-Kyoung Koo, Sabine Dietmann, Susan E. Davies, Raaj K. Praseedom, Ruby Lieshout, Jan N. M. IJzermans, Stephen J. Wigmore, Kourosh Saeb-Parsy, Mathew J. Garnett, Luc J.W. van der Laan & Meritxell Huch
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
published pages: 1424-1435, ISSN: 1078-8956, DOI: 10.17863/CAM.14402
Nature medicine 23 2019-06-13

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