Opendata, web and dolomites

GLIODIABESITY SIGNED

ROLE OF THE TANYCYTIC BARRIER AT THE BLOOD-HYPOTHALAMUS INTERFACE DURING METABOLIC DISORDER DEVELOPMENT

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GLIODIABESITY project word cloud

Explore the words cloud of the GLIODIABESITY project. It provides you a very rough idea of what is the project "GLIODIABESITY" about.

modified    diabetes    reduces    expand    transport    mechanisms    periphery    obesity    deficient    insulin    tanycytes    borne    career    fat    possibility    mechanism    ventricle    paradoxically    metabolic    death    conduit    obese    barriers    limiting    anticipated    body    raises    levels    age    solid    formative    action    boosting    besides    scientific    hold    barrier    cerebrospinal    critical    underlying    clinical    administration    combination    genetically    reduce    leptin    models    csf    blunted    expenditure    brain    paving    shuttling    collaborations    floor    homeostasis    circulating    closer    vivo    endowed    diseases    host    display    diet    signals    fail    energy    alteration    neural    disorders    convey    networks    sites    hyperphagia    demonstrated    blood    hypothalamic    proportion    regulate    human    therapeutic    adiposity    mice    humans    lining    defective    patients    appetite    strengthen    elucidate    treating    hypothalamus    play    molecular    resistance    pathophysiology    laboratory    contents    glia    onset    vitro    fluid    responsible   

Project "GLIODIABESITY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LILLE II - DROIT ET SANTE 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website http://hypothalamus.eu/
 Total cost 173˙076 €
 EC max contribution 173˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LILLE FR (LILLE) coordinator 173˙076.00
2    UNIVERSITE DE LILLE II - DROIT ET SANTE FR (Lille) coordinator 0.00

Map

 Project objective

Metabolic disorders such as obesity and diabetes are age-related diseases, and lead cause of death in Europe. Adiposity signals such as leptin and insulin, whose circulating levels are in proportion to body fat, convey metabolic information to neural networks that regulate energy homeostasis in the hypothalamus. In leptin-deficient humans and mice, leptin administration effectively reduces hyperphagia and obesity. Paradoxically, most cases of obesity display high circulating leptin levels that fail to reduce appetite or increase energy expenditure. This raises the possibility that leptin transport across the blood-brain barrier to the cerebrospinal fluid (CSF) or to its sites of action within the hypothalamus is a limiting step defective in obese patients. The host laboratory recently demonstrated that tanycytes, a hypothalamic glia lining the floor of the third ventricle, were responsible for shuttling leptin from the periphery to the CSF and that such conduit was blunted in mice with diet-induced obesity. Leptin transport by tanycytes could thus play a critical role in the pathophysiology of leptin resistance. The overall objective of this project is to further elucidate whether the alteration of the adiposity signals transport into the metabolic brain across hypothalamic barriers is the main cause of the onset of obesity. To this end, a combination of in vitro and in vivo approaches, using genetically modified mice and pre-clinical models of obesity, will be implemented in order to elucidate the molecular mechanisms for the transport of blood-borne leptin into the CSF by tanycytes. It is anticipated that implementation of this project will expand our knowledge of the mechanism underlying human obesity and hold therapeutic potential for treating it. Besides, the proposed project is endowed of solid formative contents that will strengthen the experience of the applicant, boosting her future scientific career and paving the way for closer scientific collaborations.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GLIODIABESITY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GLIODIABESITY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

TARGET SLEEP (2020)

Boosting motor learning through sleep and targeted memory reactivation in ageing and Parkinson’s disease

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More