Explore the words cloud of the Amine-FUNC project. It provides you a very rough idea of what is the project "Amine-FUNC" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-04-01 to 2017-03-31|
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|1||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||coordinator||195˙454.00|
The development of new chemical transformations based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the synthesis of complex molecules dramatically. Although some progress have been achieved in this emerging area, the selective transformation of aliphatic C-H bonds is still a challenge. This proposal aims to develop a new platform for the direct activation of unactivated sp3 C-H bonds of aliphatic amines and to apply this novel C(sp3)-H functionalization technology to synthesize diverse amine compounds. A key novel concept of this project is to use an unprotected aliphatic secondary amine as a native directing group, through a remarkable 4-membered-ring cyclometallation pathway. The goals of this proposal include: (I) developing unprecedented diverse C(sp3)-H functionalization of amine technology, accessing diverse functionalized amine compounds, (II) developing novel Pd-catalyzed enantioselective C-H functionalization methods to make enantioenriched chiral molecules, (III) application of this novel C(sp3)-H functionalization technology to make a library of diverse functionalized Salbutamol and Bupropion analogues, and screen them for biological and medicinal activities.
|year||authors and title||journal||last update|
Chuan He, Matthew J. Gaunt
Ligand-Enabled Catalytic Cï£¿H Arylation of Aliphatic Amines by a Four-Membered-Ring Cyclopalladation Pathway
published pages: 15840-15844, ISSN: 1433-7851, DOI: 10.1002/anie.201508912
|Angewandte Chemie International Edition 54/52||2019-07-23|
Chuan He, Matthew J. Gaunt
Ligand-assisted palladium-catalyzed Câ€“H alkenylation of aliphatic amines for the synthesis of functionalized pyrrolidines
published pages: , ISSN: 2041-6520, DOI: 10.1039/C7SC00468K
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