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Molmechindividuality

Molecular mechanisms of neuronal connectivity - the synaptic code for variability and stereotypy

Total Cost €

0

EC-Contrib. €

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Partnership

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Project "Molmechindividuality" data sheet

The following table provides information about the project.

Coordinator
FREIE UNIVERSITAET BERLIN 

Organization address
address: KAISERSWERTHER STRASSE 16-18
city: BERLIN
postcode: 14195
website: www.fu-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.hassanlab.eu/
 Total cost 171˙684 €
 EC max contribution 171˙684 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-11-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FREIE UNIVERSITAET BERLIN DE (BERLIN) coordinator 142˙884.00
2    VIB BE (ZWIJNAARDE - GENT) participant 28˙800.00

Map

 Project objective

Behaviour emerges from an interplay of various brain regions and billions of neurons forming a network. The brain acquires its organization by a series of developmental events. The correct wiring of the brain is crucially important for all brain functions. Nevertheless, the brain is both stereotyped and variable across individuals. Currently only a subset of genes have been identified that shape specificity in connectivity and it is highly elusive what promotes variability in synaptic connectivity and whether this is behaviourally relevant. To work on these questions I have chosen the Drosophila olfactory system, which is well-defined both on the levels of circuitry and behaviour and as such well-suited to answer these question. Furthermore, from the perspective of circuitry, it is particularly appropriate as it is comprised of both deterministic and non-deterministic synaptic connectivity. In a first step to tackle the question, I will perform a screen to identify genes shaping deterministic and non-deterministic neural connectivity. In parallel, I will investigate olfactory behavioural variability in the fly and correlate this to circuitry variations on the morphological, synaptic and electrophysiological level. After identifying genes that are important for connectivity and correlating circuit to behavioural variability, I aim to modify circuit variability to alter behaviour.

 Publications

year authors and title journal last update
List of publications.
2018 Guangda Liu, Tanmay Nath, Gerit A. Linneweber, Annelies Claeys, Zhengyu Guo, Jin Li, Mercedes Bengochea, Steve De Backer, Barbara Weyn, Manu Sneyders, Hans Nicasy, Peng Yu, Paul Scheunders, Bassem A. Hassan
A simple computer vision pipeline reveals the effects of isolation on social interaction dynamics in Drosophila
published pages: e1006410, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006410
PLOS Computational Biology 14/8 2019-05-22
2017 Luis M. Franco, Zeynep Okray, Gerit A. Linneweber, Bassem A. Hassan, Emre Yaksi
Reduced Lateral Inhibition Impairs Olfactory Computations and Behaviors in a Drosophila Model of Fragile X Syndrome
published pages: 1111-1123, ISSN: 0960-9822, DOI: 10.1016/j.cub.2017.02.065
Current Biology 27/8 2019-05-22

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