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SO-CMA

Improving the safety of oral immunotherapy for cow's milk allergy in children

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EC-Contrib. €

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Project "SO-CMA" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://clinicaltrials.gov/ct2/show/NCT02216175
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-07   to  2019-05-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

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 Project objective

Background: Food allergy affects 6% of children in the EU, and has a major impact on quality of life, nutrition, health-economics and the food production industry. Cow’s milk (CM) is a common cause, and can be particularly problematic due to the ubiquitous nature of CM in foods. Strict dietary avoidance is difficult to achieve, and unpredictable life-threatening accidental reactions are common, leading to anxiety and social restrictions for patients and families. Oral immunotherapy (OIT) has been shown to be efficacious but is not widely accepted as routine treatment, due to significant safety concerns – allergic reactions are common, and can be particularly severe in CM-OIT. Objective: To improve the safety of OIT for CM allergy. Proposed methods: WP1 - Systematic review of the literature to identify features of published OIT protocols that are associated with improved safety. WP2 - Assessment of human immune responses to candidate modified CM proteins (proven to be both non-allergenic and tolerising in murine models) as potential tools for immunotherapy. WP3. Phase 2/3 clinical trial to assess whether a sublingual pre-treatment phase can improve the safety of OIT in CM allergic children. Deliverables: 1) Systematic review to identify features of CM-OIT associated with improved safety. 2) Evidence on the immunogenicity of candidate modified CM proteins in humans, which will reflect their suitability as immunotherapy agents in the future. 3) Data relating to whether an initial sublingual phase can improve the safety of CM-OIT. 4) Pilot data on mechanisms underlying the immune-modulation induced by OIT. 5) Skills transference to the applicant to become a highly qualified independent researcher, with expertise in OIT for food allergy at an International level. 6) Consolidation of the host institution as a centre of excellence in food immunotherapy, including the potential for tolerising modified proteins to improve OIT safety and efficacy.

 Publications

year authors and title journal last update
List of publications.
2017 A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, JL Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
Oral immunotherapy for food allergy: a spanish guideline - Part 2. Immunotherapy Egg and Milk Spanish Guide (items guide)
published pages: , ISSN: 1018-9068, DOI: 10.18176/jiaci.0178
Journal of Investigational Allergology and Clinical Immunology 27/5 2019-06-13
2016 Marta Vazquez-Ortiz, Paul J. Turner
Improving the safety of oral immunotherapy for food allergy
published pages: 117-125, ISSN: 0905-6157, DOI: 10.1111/pai.12510
Pediatric Allergy and Immunology 27/2 2019-06-13
2017 A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, V De la Hoz, JL Corzo, R Del Olmo, O Dominguez, V Fuentes-Aparicio, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase
published pages: 225-237, ISSN: 1018-9068, DOI: 10.18176/jiaci.0177
Journal of Investigational Allergology and Clinical Immunology 27/4 2019-06-13

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