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SO-CMA

Improving the safety of oral immunotherapy for cow's milk allergy in children

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SO-CMA project word cloud

Explore the words cloud of the SO-CMA project. It provides you a very rough idea of what is the project "SO-CMA" about.

nature review accepted ubiquitous proven wp1 routine foods dietary expertise anxiety social avoidance economics children tools restrictions life allergic centre 6 human literature oit modulation health host allergenic cow milk difficult reflect food trial clinical skills industry treatment modified protocols humans researcher excellence international qualified wp3 systematic unpredictable immunotherapy reactions proteins background cm families allergy quality consolidation efficacy initial independent severe candidate pilot shown suitability data underlying tolerising sublingual strict mechanisms immunogenicity immune oral nutrition models patients efficacious safety wp2 transference agents murine accidental published threatening

Project "SO-CMA" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://clinicaltrials.gov/ct2/show/NCT02216175
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-03-07 to 2019-05-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

Background: Food allergy affects 6% of children in the EU, and has a major impact on quality of life, nutrition, health-economics and the food production industry. Cow’s milk (CM) is a common cause, and can be particularly problematic due to the ubiquitous nature of CM in foods. Strict dietary avoidance is difficult to achieve, and unpredictable life-threatening accidental reactions are common, leading to anxiety and social restrictions for patients and families. Oral immunotherapy (OIT) has been shown to be efficacious but is not widely accepted as routine treatment, due to significant safety concerns – allergic reactions are common, and can be particularly severe in CM-OIT. Objective: To improve the safety of OIT for CM allergy. Proposed methods: WP1 - Systematic review of the literature to identify features of published OIT protocols that are associated with improved safety. WP2 - Assessment of human immune responses to candidate modified CM proteins (proven to be both non-allergenic and tolerising in murine models) as potential tools for immunotherapy. WP3. Phase 2/3 clinical trial to assess whether a sublingual pre-treatment phase can improve the safety of OIT in CM allergic children. Deliverables: 1) Systematic review to identify features of CM-OIT associated with improved safety. 2) Evidence on the immunogenicity of candidate modified CM proteins in humans, which will reflect their suitability as immunotherapy agents in the future. 3) Data relating to whether an initial sublingual phase can improve the safety of CM-OIT. 4) Pilot data on mechanisms underlying the immune-modulation induced by OIT. 5) Skills transference to the applicant to become a highly qualified independent researcher, with expertise in OIT for food allergy at an International level. 6) Consolidation of the host institution as a centre of excellence in food immunotherapy, including the potential for tolerising modified proteins to improve OIT safety and efficacy.

Publications

List of publications.
year	authors and title	journal	last update
2017	A Martorell, E Alonso, L EcheverrÃa, C Escudero, R GarcÃa-RodrÃguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, JL Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F MartÃn-MuÃ±oz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P RodrÃguez del RÃo, M RodrÃguez, F Ruano, S SÃ¡nchez-GarcÃa, S Terrados, L Valdesoiro, M Vazquez-Ortiz Oral immunotherapy for food allergy: a spanish guideline - Part 2. Immunotherapy Egg and Milk Spanish Guide (items guide) published pages: , ISSN: 1018-9068, DOI: 10.18176/jiaci.0178	Journal of Investigational Allergology and Clinical Immunology 27/5	2019-06-13
2016	Marta Vazquez-Ortiz, Paul J. Turner Improving the safety of oral immunotherapy for food allergy published pages: 117-125, ISSN: 0905-6157, DOI: 10.1111/pai.12510	Pediatric Allergy and Immunology 27/2	2019-06-13
2017	A Martorell, E Alonso, L EcheverrÃa, C Escudero, R GarcÃa-RodrÃguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, V De la Hoz, JL Corzo, R Del Olmo, O Dominguez, V Fuentes-Aparicio, H Larramona, F MartÃn-MuÃ±oz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P RodrÃguez del RÃo, M RodrÃguez, F Ruano, S SÃ¡nchez-GarcÃa, S Terrados, L Valdesoiro, M Vazquez-Ortiz Oral Immunotherapy for Food Allergy: A Spanish Guideline. Immunotherapy Egg and Milk Spanish Guide (ITEMS Guide). Part I: Cow Milk and Egg Oral Immunotherapy: Introduction, Methodology, Rationale, Current State, Indications, Contraindications, and Oral Immunotherapy Build-up Phase published pages: 225-237, ISSN: 1018-9068, DOI: 10.18176/jiaci.0177	Journal of Investigational Allergology and Clinical Immunology 27/4	2019-06-13

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