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NANOCARB

Self-selection of a multivalent nanosystem for carbohydrate recognition

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NANOCARB project word cloud

Explore the words cloud of the NANOCARB project. It provides you a very rough idea of what is the project "NANOCARB" about.

receptors units diagnostics immobilized benefits orientale surface recognition covalently opportunity therapeutics molecules platform fill turned biology difficult spontaneously independent visibility dynamic dcc recognize career starting scientific engagement involve public milan secondment chemistry frontier distinguishing multivalent lay skills researcher water carbohydrates combinatorial combined excellent bind organization input prepare carbohydrate nanocarb innovative university prospective synthetic nanoparticle generating ipr host formed itself training kick groups lombardi excellence conference preparation context nanosystem self running class manuscript er molecular designing original group receptor nanotechnology lacunes site external remote selectively interphase yielding vivo gold prof networking piemonte

Project "NANOCARB" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.chimica.unipd.it/leonard.prins/
Total cost	180˙277 €
EC max contribution	180˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-04-15 to 2017-04-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PADOVA UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	coordinator	180˙277.00

Map

Project objective

The main objective of the NANOCARB project is to prepare the experienced researcher (ER) for an independent career through the implementation of a frontier research project and a training programme covering all aspects that are required for running a research group. The NANOCARB project has the scientific objective to build up an original method for the development of an innovative class of carbohydrate receptors using dynamic combinatorial chemistry (DCC) on the surface of a gold nanoparticle. Molecular receptors capable of carbohydrate recognition have a great potential in diagnostics and therapeutics. However, this prospective is still remote as it has turned out that designing synthetic receptor molecules able to selectively bind carbohydrates in water is very difficult. The distinguishing feature of this project is that the recognition site for the carbohydrate target is spontaneously formed, driven by the carbohydrate target itself. The self-selected recognition units will then be immobilized covalently on the gold nanoparticle, yielding a multivalent nanosystem able to recognize its target also in vivo. The project is on the interphase between chemistry, biology and nanotechnology providing an excellent opportunity for the experienced researcher (ER) to develop skills in these areas. Training excellence within the context of becoming independent researcher will involve manuscript and research proposal preparation, public engagement, IPR issues, networking, and conference organization. The project also benefits from external input and a secondment from other groups (Prof. Lay, University of Milan and Prof. Lombardi, University of Piemonte Orientale) in order to fill lacunes not available at the host institution. The combined package of scientific and training objectives will make the NANOCARB project an excellent platform for kick-starting the independent career of the ER and generating a strong visibility to the host institution.

Publications

List of publications.
year	authors and title	journal	last update
2017	Jack Chen, Subhabrata Maiti, Ilaria Fortunati, Camilla Ferrante, Leonard J. Prins Temporal Control over Transient Chemical Systems using Structurally Diverse Chemical Fuels published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201701533	Chemistry - A European Journal	2019-07-23
2016	Subhabrata Maiti, Ilaria Fortunati, Camilla Ferrante, Paolo Scrimin, Leonard J. Prins Dissipative self-assembly of vesicular nanoreactors published pages: 725-731, ISSN: 1755-4330, DOI: 10.1038/nchem.2511	Nature Chemistry 8/7	2019-07-23
2017	Flavio della Sala, Simona Neri, Subhabrata Maiti, Jack L-Y Chen, Leonard J Prins Transient self-assembly of molecular nanostructures driven by chemical fuels published pages: 27-33, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2016.10.014	Current Opinion in Biotechnology 46	2019-07-23
2017	Subhabrata Maiti, Leonard J. Prins A modular self-assembled sensing system for heavy metal ions with tunable sensitivity and selectivity published pages: , ISSN: 0040-4020, DOI: 10.1016/j.tet.2017.05.028	Tetrahedron	2019-07-23

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The information about "NANOCARB" are provided by the European Opendata Portal: CORDIS opendata.