Explore the words cloud of the MHAtriCell project. It provides you a very rough idea of what is the project "MHAtriCell" about.
The following table provides information about the project.
QUEEN MARY UNIVERSITY OF LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-06-15 to 2017-06-14|
Take a look of project's partnership.
|1||QUEEN MARY UNIVERSITY OF LONDON||UK (LONDON)||coordinator||183˙454.00|
In recent years creation of artificial matrices from relatively simple biomaterials that can support tumour growth in 3D is becoming an increasingly popular platform for recreating the tumour microenvironment (TME) in vitro since 3D cell culture models can more realistically reflect the in vivo TME compared with 2D monolayer cultures. In this project, we will design and fabricate novel hydrogel matrices comprising of hyaluronan crosslinked with collagen-like triple helical peptide amphiphiles (PAs). The novel HA-PA matrix will contain built-in cell adhesion sequence, HA-binding motif and matrix metalloproteinase (MMP) cleavable sequences. We will characterise these 3D hydrogel matrices to support the encapsulation and culture of ovarian cancer cells. The MMP-assisted hydrogel degradation, migration and invasion of ovarian cancer will be studied on these models using advanced electron microscopic techniques and enzyme assays. In the final phase of our study we will characterise the inhibitory potency of a highly potent and selector inhibitor of MMP-2 and MMP-9 on this system. The findings from this study will have direct implications in understanding the mechanisms associated with ovarian cancer dissemination and the newly developed hydrogel matrix can find further use as a novel biomaterial in tissue engineering and as a 3D cell culture model in cancer drug discovery and delivery.
|year||authors and title||journal||last update|
J. Banerjee, H. S. Azevedo
Crafting of functional biomaterials by directed molecular self-assembly of triple helical peptide building blocks
published pages: , ISSN: 2042-8898, DOI:
Jayati Banerjee, Yejiao Shi, Helena S. Azevedo
In vitro bloodâ€“brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms
published pages: , ISSN: 1359-6446, DOI: 10.1016/j.drudis.2016.05.020
|Drug Discovery Today||2019-07-24|
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The information about "MHATRICELL" are provided by the European Opendata Portal: CORDIS opendata.
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