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MHAtriCell

Hyaluronan-rich matrices crosslinked with collagen-like peptides for 3D culture of ovarian cancer cells

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MHAtriCell" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.sems.qmul.ac.uk/research/projects/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-15   to  2017-06-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

In recent years creation of artificial matrices from relatively simple biomaterials that can support tumour growth in 3D is becoming an increasingly popular platform for recreating the tumour microenvironment (TME) in vitro since 3D cell culture models can more realistically reflect the in vivo TME compared with 2D monolayer cultures. In this project, we will design and fabricate novel hydrogel matrices comprising of hyaluronan crosslinked with collagen-like triple helical peptide amphiphiles (PAs). The novel HA-PA matrix will contain built-in cell adhesion sequence, HA-binding motif and matrix metalloproteinase (MMP) cleavable sequences. We will characterise these 3D hydrogel matrices to support the encapsulation and culture of ovarian cancer cells. The MMP-assisted hydrogel degradation, migration and invasion of ovarian cancer will be studied on these models using advanced electron microscopic techniques and enzyme assays. In the final phase of our study we will characterise the inhibitory potency of a highly potent and selector inhibitor of MMP-2 and MMP-9 on this system. The findings from this study will have direct implications in understanding the mechanisms associated with ovarian cancer dissemination and the newly developed hydrogel matrix can find further use as a novel biomaterial in tissue engineering and as a 3D cell culture model in cancer drug discovery and delivery.

 Publications

year authors and title journal last update
List of publications.
2017 J. Banerjee, H. S. Azevedo
Crafting of functional biomaterials by directed molecular self-assembly of triple helical peptide building blocks
published pages: , ISSN: 2042-8898, DOI:
Interface Focus 2019-07-24
2016 Jayati Banerjee, Yejiao Shi, Helena S. Azevedo
In vitro blood–brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms
published pages: , ISSN: 1359-6446, DOI: 10.1016/j.drudis.2016.05.020
Drug Discovery Today 2019-07-24

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