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VIVO_MECH_COLL_MIGRA

Biomechanical analysis of in vivo directional collective migration

Total Cost €

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EC-Contrib. €

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Partnership

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Project "VIVO_MECH_COLL_MIGRA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.researchgate.net/profile/Elias_Barriga
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-02   to  2018-02-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

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 Project objective

Directional cell migration is important in physiology and pathology. Molecular mechanisms regulating directional migration are largely studied; but the role of mechanical cues and their interplay with biochemical signals during directional migration is poorly understood. To address this we will use Neural Crest (NC) cells, a highly migratory embryonic cell population. Evidence about how chemical cues regulate NC migration has accumulated, but nothing is known about the biomechanics of NC migration. This proposal focuses on understanding how NC interacts with the mechanical cues from its environment during directional migration in vivo, as well as understanding the molecular nature of this interaction. Thus, our aims are: Aim 1) to study the role of mechanical cues in vivo and their interplay with chemical signals during in vivo NC migration. Aim 2) identify the molecular mechanism by which the mechanical properties of the substrate are sensed and translated as signals into the NC, and to test the role of Nedd9 as a key component of this process. (Nedd9 appears in a screening that I performed to identify potential NC mechanosensors). These studies will provide new tools and information on the role of mechanical cues during directional migration in vivo, how these cues interact with chemical guidance, how are they integrated as cellular signalling within cells? These questions are poorly studied aspects of cell migration, thus our results will be a real contribution to the state-of-the-art in cell migration. This multidisciplinary proposal is will be mutually beneficial, providing the host and me with new collaborations. A research line will be created in ERA with NC as a model to study biophysics of migration in vivo. I will complement my current skills with new knowledge in biophysics of cell migration and managerial skills; this will have a countless impact in the career that I project as an independent researcher in the cell migration field.

 Publications

year authors and title journal last update
List of publications.
2017 Isabel Bahm, Elias H. Barriga, Antonina Frolov, Eric Theveneau, Paul Frankel, Roberto Mayor
PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration
published pages: 2456-2468, ISSN: 0950-1991, DOI: 10.1242/dev.147926
Development 144/13 2019-06-14
2018 Mansour Alkobtawi, Heather Ray, Elias H Barriga, Mauricio Moreno, Ryan Kerney, Anne-Helene Monsoro-Burq, Jean-Pierre Saint-Jeannet, Roberto Mayor
Characterization of Pax3 and Sox10 transgenic Xenopus laevis embryos as tools to study neural crest development
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.02.020
Developmental Biology 2019-06-14
2018 Elias H. Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor
Tissue stiffening coordinates morphogenesis by triggering collective cell migration in vivo
published pages: 523-527, ISSN: 0028-0836, DOI: 10.1038/nature25742
Nature 554/7693 2019-06-14
2017 Elias Barriga, Kristian Franze, Guillaume Charras, Roberto Mayor
How mechanics orchestrate morphogenesis: Mesodermal stiffening triggers neural crest migration in vivo
published pages: S46, ISSN: 0925-4773, DOI: 10.1016/j.mod.2017.04.080
Mechanisms of Development 145 2019-06-14

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