Opendata, web and dolomites


Predicting the effects of gut microbiota and diet on an individual’s drug response and safety

Total Cost €


EC-Contrib. €






 BugTheDrug project word cloud

Explore the words cloud of the BugTheDrug project. It provides you a very rough idea of what is the project "BugTheDrug" about.

microbiota    optimize    first    computational    illustrate    edge    genome    human    biochemical    demand    influence    stratify    individuals    resolution    dietary    integration    conceptually    prescription    quantitative    interactions    molecular    limit    combine    influences    technologically    variability    mechanistic    pilot    medicine    modulated    harm    maximizing    benefits    drugs    patients    thereby    diet    contribution    precision    exhibits    innovative    researched    biology    environmental    intervention    insights    prior    reactions    understand    variation    paradigm    individual    personalized    pharmacology    minimizing    heterogeneity    genetic    genes    gut    realistic    body    network    explicitly    subjects    progress    variations    metabolism    framework    modeling    proteins    bioavailability    clinically    physiological    breakthrough    versatile    consequently    perform    microbial    metabolizes    models    drug    microbiology    nutrition    cutting    bugthedrug   

Project "BugTheDrug" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙687˙458 €
 EC max contribution 1˙687˙458 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙687˙458.00


 Project objective

Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the harm of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity in drug responses. Consequently, novel approaches are required that explicitly account for individual variations in response to environmental influences, in addition to genetic variation. The human gut microbiota metabolizes drugs and is modulated by diet, and it exhibits significant variation among individuals. However, the influence of the gut microbiota on drug failure or drug side effects is under-researched. In this study, I will combine whole-body, genome-scale molecular resolution modeling of human metabolism and human gut microbial metabolism, which represents a network of genes, proteins, and biochemical reactions, with physiological, clinically relevant modeling of drug responses. I will perform two pilot studies on human subjects to illustrate that this innovative, versatile computational modeling framework can be used to stratify patients prior to drug prescription and to optimize drug bioavailability through personalized dietary intervention. With these studies, BugTheDrug will advance mechanistic understanding of drug-microbiota-diet interactions and their contribution to individual drug responses. I will perform the first integration of cutting-edge approaches and novel insights from four distinct research areas: systems biology, quantitative systems pharmacology, microbiology, and nutrition. BugTheDrug conceptually and technologically addresses the demand for novel approaches to the study of individual variability, thereby providing breakthrough support for progress in precision medicine.


year authors and title journal last update
List of publications.
2019 Marouen Ben Guebila, Ines Thiele
Predicting gastrointestinal drug effects using contextualized metabolic models
published pages: e1007100, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1007100
PLOS Computational Biology 15/6 2019-10-03
2019 Almut Heinken, Dmitry A. Ravcheev, Federico Baldini, Laurent Heirendt, Ronan M. T. Fleming, Ines Thiele
Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease
published pages: 75, ISSN: 2049-2618, DOI: 10.1186/s40168-019-0689-3
Microbiome 7/1 2019-10-03
2019 Alberto Noronha, Jennifer Modamio, Yohan Jarosz, Elisabeth Guerard, Nicolas Sompairac, German Preciat, Anna Dröfn Daníelsdóttir, Max Krecke, Diane Merten, Hulda S Haraldsdóttir, Almut Heinken, Laurent Heirendt, Stefanía Magnúsdóttir, Dmitry A Ravcheev, Swagatika Sahoo, Piotr Gawron, Lucia Friscioni, Beatriz Garcia, Mabel Prendergast, Alberto Puente, Mariana Rodrigues, Akansha Roy, Mouss Rou
The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
published pages: D614-D624, ISSN: 0305-1048, DOI:
Nucleic Acids Research 47(D1) 2019-10-03
2018 Noronha, A., Modamio, J., Jarosz, Y., Sompairac, N., Gonzalez, G., Danelsdttir, A.D., Krecke, M., Merten, D., Haraldsdttir, H.S., Heinken, A., Heirendt, L., Magnsdottir, S., Ravcheev, D.A., Sahoo, S., Gawron, P., Guerard, E., Friscioni, L., Garcia, B., Prendergast, M., Rodrigues, M., Roy, A., Rouquaya, M., Wiltgen, L., Zagare, A., John, E., Krueger, M., Kuperstein, I., Zinovyev, A., Schneider, R., Fleming, R.M.T., Thiele, I.
OUP accepted manuscript
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky992
Nucleic Acids Research 2019-05-16
2018 Federico Baldini, Almut Heinken, Laurent Heirendt, Stefania Magnusdottir, Ronan M T Fleming, Ines Thiele
The Microbiome Modeling Toolbox: from microbial interactions to personalized microbial communities
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty941
Bioinformatics 2019-05-16

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BUGTHEDRUG" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BUGTHEDRUG" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SmartForests (2020)

Smart Forests: Transforming Environments into Social-Political Technologies

Read More  

DYNAPOL (2019)

Modeling approaches toward bioinspired dynamic materials

Read More  

CerQuS (2019)

Certified Quantum Security

Read More