BugTheDrug SIGNED
Predicting the effects of gut microbiota and diet on an individual’s drug response and safety
Total Cost €
0EC-Contrib. €
0Partnership
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Project "BugTheDrug" data sheet
The following table provides information about the project.
| Coordinator |
NATIONAL UNIVERSITY OF IRELAND GALWAY
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 1˙687˙458 € |
| EC max contribution | 1˙687˙458 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-04-01 to 2023-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | NATIONAL UNIVERSITY OF IRELAND GALWAY | IE (Galway) | coordinator | 1˙687˙458.00 |
| 2 | UNIVERSITE DU LUXEMBOURG | LU (ESCH-SUR-ALZETTE) | participant | 0.00 |
Map
Project objective
Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the harm of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity in drug responses. Consequently, novel approaches are required that explicitly account for individual variations in response to environmental influences, in addition to genetic variation. The human gut microbiota metabolizes drugs and is modulated by diet, and it exhibits significant variation among individuals. However, the influence of the gut microbiota on drug failure or drug side effects is under-researched. In this study, I will combine whole-body, genome-scale molecular resolution modeling of human metabolism and human gut microbial metabolism, which represents a network of genes, proteins, and biochemical reactions, with physiological, clinically relevant modeling of drug responses. I will perform two pilot studies on human subjects to illustrate that this innovative, versatile computational modeling framework can be used to stratify patients prior to drug prescription and to optimize drug bioavailability through personalized dietary intervention. With these studies, BugTheDrug will advance mechanistic understanding of drug-microbiota-diet interactions and their contribution to individual drug responses. I will perform the first integration of cutting-edge approaches and novel insights from four distinct research areas: systems biology, quantitative systems pharmacology, microbiology, and nutrition. BugTheDrug conceptually and technologically addresses the demand for novel approaches to the study of individual variability, thereby providing breakthrough support for progress in precision medicine.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Marouen Ben Guebila, Ines Thiele Predicting gastrointestinal drug effects using contextualized metabolic models published pages: e1007100, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1007100 |
PLOS Computational Biology 15/6 | 2019-10-03 |
| 2019 |
Almut Heinken, Dmitry A. Ravcheev, Federico Baldini, Laurent Heirendt, Ronan M. T. Fleming, Ines Thiele Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease published pages: 75, ISSN: 2049-2618, DOI: 10.1186/s40168-019-0689-3 |
Microbiome 7/1 | 2019-10-03 |
| 2019 |
Alberto Noronha, Jennifer Modamio, Yohan Jarosz, Elisabeth Guerard, Nicolas Sompairac, German Preciat, Anna Dröfn DanÃelsdóttir, Max Krecke, Diane Merten, Hulda S Haraldsdóttir, Almut Heinken, Laurent Heirendt, StefanÃa Magnúsdóttir, Dmitry A Ravcheev, Swagatika Sahoo, Piotr Gawron, Lucia Friscioni, Beatriz Garcia, Mabel Prendergast, Alberto Puente, Mariana Rodrigues, Akansha Roy, Mouss Rou The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease published pages: D614-D624, ISSN: 0305-1048, DOI: |
Nucleic Acids Research 47(D1) | 2019-10-03 |
| 2018 |
Noronha, A., Modamio, J., Jarosz, Y., Sompairac, N., Gonzalez, G., Danelsdttir, A.D., Krecke,
M., Merten, D., Haraldsdttir, H.S., Heinken, A., Heirendt, L., Magnsdottir, S., Ravcheev, D.A.,
Sahoo, S., Gawron, P., Guerard, E., Friscioni, L., Garcia, B., Prendergast, M., Rodrigues, M.,
Roy, A., Rouquaya, M., Wiltgen, L., Zagare, A., John, E., Krueger, M., Kuperstein, I., Zinovyev,
A., Schneider, R., Fleming, R.M.T., Thiele, I. OUP accepted manuscript published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky992 |
Nucleic Acids Research | 2019-05-16 |
| 2018 |
Federico Baldini, Almut Heinken, Laurent Heirendt, Stefania Magnusdottir, Ronan M T Fleming, Ines Thiele The Microbiome Modeling Toolbox: from microbial interactions to personalized microbial communities published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty941 |
Bioinformatics | 2019-05-16 |
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