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BugTheDrug SIGNED

Predicting the effects of gut microbiota and diet on an individual’s drug response and safety

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BugTheDrug project word cloud

Explore the words cloud of the BugTheDrug project. It provides you a very rough idea of what is the project "BugTheDrug" about.

biochemical    gut    body    contribution    precision    perform    modulated    versatile    interactions    cutting    individual    subjects    mechanistic    stratify    medicine    patients    physiological    personalized    edge    genome    pilot    drug    progress    integration    benefits    bioavailability    environmental    demand    conceptually    limit    prior    modeling    thereby    genes    understand    variations    influence    variation    paradigm    resolution    network    variability    individuals    bugthedrug    researched    heterogeneity    realistic    technologically    combine    clinically    models    exhibits    intervention    drugs    quantitative    illustrate    insights    explicitly    metabolizes    proteins    biology    minimizing    innovative    framework    computational    pharmacology    dietary    consequently    molecular    prescription    influences    microbiology    microbiota    reactions    nutrition    diet    maximizing    first    microbial    genetic    optimize    metabolism    breakthrough    harm    human   

Project "BugTheDrug" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙687˙458 €
 EC max contribution 1˙687˙458 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙687˙458.00
2    UNIVERSITE DU LUXEMBOURG LU (ESCH-SUR-ALZETTE) participant 0.00

Map

 Project objective

Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the harm of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity in drug responses. Consequently, novel approaches are required that explicitly account for individual variations in response to environmental influences, in addition to genetic variation. The human gut microbiota metabolizes drugs and is modulated by diet, and it exhibits significant variation among individuals. However, the influence of the gut microbiota on drug failure or drug side effects is under-researched. In this study, I will combine whole-body, genome-scale molecular resolution modeling of human metabolism and human gut microbial metabolism, which represents a network of genes, proteins, and biochemical reactions, with physiological, clinically relevant modeling of drug responses. I will perform two pilot studies on human subjects to illustrate that this innovative, versatile computational modeling framework can be used to stratify patients prior to drug prescription and to optimize drug bioavailability through personalized dietary intervention. With these studies, BugTheDrug will advance mechanistic understanding of drug-microbiota-diet interactions and their contribution to individual drug responses. I will perform the first integration of cutting-edge approaches and novel insights from four distinct research areas: systems biology, quantitative systems pharmacology, microbiology, and nutrition. BugTheDrug conceptually and technologically addresses the demand for novel approaches to the study of individual variability, thereby providing breakthrough support for progress in precision medicine.

 Publications

year authors and title journal last update
List of publications.
2019 Marouen Ben Guebila, Ines Thiele
Predicting gastrointestinal drug effects using contextualized metabolic models
published pages: e1007100, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1007100
PLOS Computational Biology 15/6 2019-10-03
2019 Almut Heinken, Dmitry A. Ravcheev, Federico Baldini, Laurent Heirendt, Ronan M. T. Fleming, Ines Thiele
Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease
published pages: 75, ISSN: 2049-2618, DOI: 10.1186/s40168-019-0689-3
Microbiome 7/1 2019-10-03
2019 Alberto Noronha, Jennifer Modamio, Yohan Jarosz, Elisabeth Guerard, Nicolas Sompairac, German Preciat, Anna Dröfn Daníelsdóttir, Max Krecke, Diane Merten, Hulda S Haraldsdóttir, Almut Heinken, Laurent Heirendt, Stefanía Magnúsdóttir, Dmitry A Ravcheev, Swagatika Sahoo, Piotr Gawron, Lucia Friscioni, Beatriz Garcia, Mabel Prendergast, Alberto Puente, Mariana Rodrigues, Akansha Roy, Mouss Rou
The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease
published pages: D614-D624, ISSN: 0305-1048, DOI:
Nucleic Acids Research 47(D1) 2019-10-03
2018 Noronha, A., Modamio, J., Jarosz, Y., Sompairac, N., Gonzalez, G., Danelsdttir, A.D., Krecke, M., Merten, D., Haraldsdttir, H.S., Heinken, A., Heirendt, L., Magnsdottir, S., Ravcheev, D.A., Sahoo, S., Gawron, P., Guerard, E., Friscioni, L., Garcia, B., Prendergast, M., Rodrigues, M., Roy, A., Rouquaya, M., Wiltgen, L., Zagare, A., John, E., Krueger, M., Kuperstein, I., Zinovyev, A., Schneider, R., Fleming, R.M.T., Thiele, I.
OUP accepted manuscript
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky992
Nucleic Acids Research 2019-05-16
2018 Federico Baldini, Almut Heinken, Laurent Heirendt, Stefania Magnusdottir, Ronan M T Fleming, Ines Thiele
The Microbiome Modeling Toolbox: from microbial interactions to personalized microbial communities
published pages: , ISSN: 1367-4803, DOI: 10.1093/bioinformatics/bty941
Bioinformatics 2019-05-16

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