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Subpopulations

Investigating Fibrotic and Regenerative Fibroblast Populations in Muscular Dystrophy

Total Cost €

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EC-Contrib. €

0

Partnership

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 Subpopulations project word cloud

Explore the words cloud of the Subpopulations project. It provides you a very rough idea of what is the project "Subpopulations" about.

interact    model    tracing    morgan    muscular    populations    repair    personalized    regimens    determined    laboratory    fibrotic    cellular    tissue    diseases    therapeutics    ongoing    flow    fundamental    chemokines    proteins    shift    excessive    replacing    accumulation    muscle    fibrosis    question    subpopulations    skeletal    uncontrolled    inhibit    injury    site    stabilize    scars    progression    damage    dr    phenotype    duchenne    resident    satellite    favouring    map    fibroblast    fibroblasts    mouse    pathological    necrosis    inflammation    cell    heterogeneity    medicines    secrete    degeneration    provocative    cells    regenerative    extract    outcome    regeneration    dystrophic    adipose    elucidate    prominent    migration    continual    lineage    inflammatory    dmd    shifts    cytometry    proliferate    chronic    following    fate    extracellular    function    dystrophy    reprogram    cytokines    healthy    recruit    release    transplant    aberrant   

Project "Subpopulations" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Following skeletal muscle injury, resident fibroblasts proliferate and release cytokines that enhance muscle regeneration. Fibroblasts also secrete chemokines to recruit cellular migration, and extracellular proteins that stabilize the site of injury. However, in chronic diseases, such as Duchenne Muscular Dystrophy (DMD), continual muscle damage shifts fibroblasts towards an uncontrolled fibrotic and inflammatory phenotype. Excessive fibrosis and inflammation are prominent pathological features of DMD and inhibit muscle function and repair by replacing the tissue with fibrotic scars, adipose tissue, and necrosis. The fundamental question my proposal will address is why fibroblasts shift from regenerative-favouring cells in healthy muscle, but lead to fibrotic accumulation in dystrophic muscle. My proposal will use a novel approach to investigate specific fibroblast populations. Whether all fibroblasts are capable of promoting both fibrosis and muscle regeneration, or if there are fibroblast subpopulations that produce factors leading to one or the other outcome, is not currently known. The heterogeneity of fibroblast populations within skeletal muscle remains to be determined. By using lineage tracing and flow cytometry to map cell fate during the progression of muscle degeneration in a mouse model of DMD, my project will identify aberrant changes in fibroblast populations and elucidate how these cells interact with inflammatory cells and satellite cells. Finally, I will extract dystrophic fibroblasts and transplant them into non-dystrophic mouse muscle to determine whether fibroblasts populations can reprogram, or shift, towards a regenerative-favouring cell fate which could lead to a new tailored field of personalized medicines. These provocative studies will be integrated with ongoing research in Dr Morgan’s laboratory aimed at developing new therapeutics regimens for DMD.

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The information about "SUBPOPULATIONS" are provided by the European Opendata Portal: CORDIS opendata.

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