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Investigating Fibrotic and Regenerative Fibroblast Populations in Muscular Dystrophy

Total Cost €


EC-Contrib. €






 Subpopulations project word cloud

Explore the words cloud of the Subpopulations project. It provides you a very rough idea of what is the project "Subpopulations" about.

chronic    shifts    duchenne    skeletal    personalized    dystrophic    therapeutics    healthy    muscle    degeneration    uncontrolled    subpopulations    stabilize    resident    fibroblast    prominent    populations    regeneration    regenerative    progression    repair    cellular    transplant    chemokines    regimens    cytokines    heterogeneity    elucidate    excessive    reprogram    satellite    outcome    secrete    flow    inflammatory    necrosis    inhibit    recruit    proliferate    pathological    map    favouring    function    shift    provocative    dystrophy    question    continual    fate    tracing    determined    cell    dr    inflammation    mouse    laboratory    medicines    tissue    dmd    accumulation    adipose    fundamental    injury    ongoing    following    morgan    migration    fibrotic    site    fibrosis    cytometry    diseases    release    proteins    lineage    scars    cells    extracellular    damage    replacing    extract    aberrant    model    phenotype    fibroblasts    interact    muscular   

Project "Subpopulations" data sheet

The following table provides information about the project.


Organization address
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00


 Project objective

Following skeletal muscle injury, resident fibroblasts proliferate and release cytokines that enhance muscle regeneration. Fibroblasts also secrete chemokines to recruit cellular migration, and extracellular proteins that stabilize the site of injury. However, in chronic diseases, such as Duchenne Muscular Dystrophy (DMD), continual muscle damage shifts fibroblasts towards an uncontrolled fibrotic and inflammatory phenotype. Excessive fibrosis and inflammation are prominent pathological features of DMD and inhibit muscle function and repair by replacing the tissue with fibrotic scars, adipose tissue, and necrosis. The fundamental question my proposal will address is why fibroblasts shift from regenerative-favouring cells in healthy muscle, but lead to fibrotic accumulation in dystrophic muscle. My proposal will use a novel approach to investigate specific fibroblast populations. Whether all fibroblasts are capable of promoting both fibrosis and muscle regeneration, or if there are fibroblast subpopulations that produce factors leading to one or the other outcome, is not currently known. The heterogeneity of fibroblast populations within skeletal muscle remains to be determined. By using lineage tracing and flow cytometry to map cell fate during the progression of muscle degeneration in a mouse model of DMD, my project will identify aberrant changes in fibroblast populations and elucidate how these cells interact with inflammatory cells and satellite cells. Finally, I will extract dystrophic fibroblasts and transplant them into non-dystrophic mouse muscle to determine whether fibroblasts populations can reprogram, or shift, towards a regenerative-favouring cell fate which could lead to a new tailored field of personalized medicines. These provocative studies will be integrated with ongoing research in Dr Morgan’s laboratory aimed at developing new therapeutics regimens for DMD.

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The information about "SUBPOPULATIONS" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-28 11:31:11) correctly updated