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Consolidating a genomic framework for exploiting lactobacilli

Total Cost €


EC-Contrib. €






 GENOLACT project word cloud

Explore the words cloud of the GENOLACT project. It provides you a very rough idea of what is the project "GENOLACT" about.

microorganisms    acquisition    genomic    transferred    proposals    dietary    meeting    placing    delineate    safe    perform    transfer    probiotics    friendlier    despite    lack    underpin    claims    gras    companies    lactate    phenotypes    moulded    efficient    ambitions    link    strains    forensically    ways    chemical    scientists    proved    live    decay    preservatives    strain    industry    genetic    bacteria    belong    health    approval    genus    characterization    efsa    regulatory    deeper    majority    chance    academic    supplementary    validating    probiotic    create    conversion    beneficial    compliance    environmentally    guidelines    risk    difficult    broad    lactobacillus    industrial    scientific    fermented    data    claim    healthier    species    proper    backbone    textile    manufacturers    lactobacilli    food    gene    genes    history    suitability    safety    surge    synthesis    actual    molecular    solutions    market    genome    difficulties    mechanisms    successful    unravel   

Project "GENOLACT" data sheet

The following table provides information about the project.


Organization address
city: Cork
postcode: T12 YN60

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Probiotics are defined as live microorganisms with a long history of safe use and a robust evidence for providing beneficial effects to the consumer. The majority of probiotic bacteria belong to Lactobacillus genus, which includes a large number of GRAS species, essential in fermented food production and for use as food preservatives. Lactobacilli have also a range of non-food applications, such as industrial production of lactate for the textile industry in environmentally friendlier ways than chemical synthesis. Despite their broad use, health claims approval by EFSA for probiotics is challenging due to scientific difficulties in validating probiotic mechanisms and a lack of proper strain characterization. Although there has been a surge in research into probiotics, the conversion into actual claims and compliance with the regulatory requirements has proved difficult. The aim of the project is to perform forensically detailed comparative genomic analysis of Lactobacillus species to i) unravel the genetic backbone that has been moulded by genome decay and gene acquisition ii) delineate the genetic features and molecular mechanisms that underpin their health-promoting effects and suitability for use, and iii) identify genes associated with the phenotypes for new food applications. A deeper insight into the safety-related issues for food strains will provide a comprehensive assessment on risk factors to be transferred to companies as supplementary safety guidelines for successful health claim proposals. Data obtained will be used to develop new dietary solutions and safe non-food applications, thus increasing manufacturers’ interest in placing beneficial products on the market and meeting the consumer’s ambitions to live healthier. Within the project, the applicant will have the chance to perform high-level research with leading scientists and create a link between academic institutions and companies for efficient technology transfer and novel industrial solutions.


year authors and title journal last update
List of publications.
2017 Elisa Salvetti, Paul W. O’Toole
The Genomic Basis of Lactobacilli as Health-Promoting Organisms
published pages: , ISSN: 2165-0497, DOI: 10.1128/microbiolspec.BAD-0011-2016
Microbiology Spectrum 5/3 2019-07-24
2017 Elisa Salvetti, Paul W. O\'Toole
When regulation challenges innovation: The case of the genus Lactobacillus
published pages: 187-194, ISSN: 0924-2244, DOI: 10.1016/j.tifs.2017.05.009
Trends in Food Science & Technology 66 2019-07-24

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The information about "GENOLACT" are provided by the European Opendata Portal: CORDIS opendata.

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