Explore the words cloud of the SorCSbalance project. It provides you a very rough idea of what is the project "SorCSbalance" about.
The following table provides information about the project.
|Coordinator Country||Belgium [BE]|
|Total cost||160˙800 €|
|EC max contribution||160˙800 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-05-01 to 2017-04-30|
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Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders. The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important. The host laboratory recently identified the sorting receptor SorCS1 as a key regulator of the synaptic abundance of glutamate receptors and adhesion molecules, including neurexins and neuroligins. SorCS1 has been associated with a variety of neural disorders, including autism, schizophrenia, and Alzheimer’s disease. I hypothesize that SorCS1 controls E/I balance in the brain by regulating the synaptic abundance of cell surface receptors. I shall test this hypothesis via the following specific aims:
Aim 1: To analyse whether SorCS1 regulates synaptic trafficking of adhesion molecules and neurotransmitter receptors under basal conditions and during synaptic activity.
Aim 2: To define how SorCS1 affects excitatory and inhibitory synapse function in vitro and in vivo.
Aim 3: To determine whether perturbed SorCS1 levels and disease-associated SorCS1 mutations affect E/I balance in neural circuits.
|year||authors and title||journal||last update|
JeffreyÂ N. Savas, LuÃsÂ F. Ribeiro, KeimpeÂ D. Wierda, Rebecca Wright, LauraÂ A. DeNardo-Wilke, HeatherÂ C. Rice, Ingrid Chamma, Yi-Zhi Wang, Roland Zemla, Mathieu LavallÃ©e-Adam, KristelÂ M. Vennekens, MatthewÂ L. Oâ€™Sullivan, JosephÂ K. Antonios, ElizabethÂ A. Hall, Olivier Thoumine, AlanÂ D. Attie, JohnÂ R. Yates, Anirvan Ghosh, Joris deÂ Wit
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
published pages: 764-780, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2015.08.007
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