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PHAGECOM

Complex parasite communities as drivers of bacterial immunity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PHAGECOM" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.exeter.ac.uk/esi/people/researchandtechnical/van_houte/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 183˙454.00

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 Project objective

CRISPR-Cas is one of several distinct bacterial defence mechanisms that provide immunity against viruses (phages) and other mobile genetic elements (MGEs; e.g. plasmids). My research aims at understanding how CRISPR-Cas-mediated immunity is affected by the complexity of MGE communities. Using evolution assays and deep sequencing techniques I aim to study (i) the evolution of CRISPR-Cas-mediated immunity in a complex MGE community (i.e. multiple phages and plasmids), and (ii) determine the associated co-evolutionary dynamics. The proposed research is highly multidisciplinary and will perfectly complement my background in biochemistry and molecular biology. It also allows me to establish collaborations with academic and industrial partners to realize applications in dairy industry and phage therapy. The project will be pivotal for my personal development to become an independent researcher and offers me the unique opportunity to work in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter. Biosciences is a leading institute in evolutionary biology, microbiology and ecology that provides excellent opportunities for academic training and personal career development. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my own background, offering exciting opportunities for knowledge exchange and will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures for the general public throughout 2015 (the Year of the Phage) to emphasize the importance of phage research for many aspects of our society, including industry and medicine.

 Publications

year authors and title journal last update
List of publications.
2016 Stineke van Houte, Angus Buckling, Edze R. Westra
Evolutionary Ecology of Prokaryotic Immune Mechanisms
published pages: 745-763, ISSN: 1092-2172, DOI: 10.1128/MMBR.00011-16
Microbiology and Molecular Biology Reviews 80/3 2019-06-18
2017 Daniel Morley, Jenny M. Broniewski, Edze R. Westra, Angus Buckling, Stineke van Houte
Host diversity limits the evolution of parasite local adaptation
published pages: 1756-1763, ISSN: 0962-1083, DOI: 10.1111/mec.13917
Molecular Ecology 26/7 2019-06-18
2016 Stineke van Houte, Alice K. E. Ekroth, Jenny M. Broniewski, Hélène Chabas, Ben Ashby, Joseph Bondy-Denomy, Sylvain Gandon, Mike Boots, Steve Paterson, Angus Buckling, Edze R. Westra
The diversity-generating benefits of a prokaryotic adaptive immune system
published pages: 385-388, ISSN: 0028-0836, DOI: 10.1038/nature17436
Nature 532/7599 2019-06-18
2016 Edze R. Westra, Andrea J. Dowling, Jenny M. Broniewski, Stineke van Houte
Evolution and Ecology of CRISPR
published pages: 307-331, ISSN: 1543-592X, DOI: 10.1146/annurev-ecolsys-121415-032428
Annual Review of Ecology, Evolution, and Systematics 47/1 2019-06-18
2016 Hélène Chabas, Stineke van Houte, Nina Molin Høyland-Kroghsbo, Angus Buckling, Edze R. Westra
Immigration of susceptible hosts triggers the evolution of alternative parasite defence strategies
published pages: 20160721, ISSN: 0962-8452, DOI: 10.1098/rspb.2016.0721
Proceedings of the Royal Society B: Biological Sciences 283/1837 2019-06-18

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