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EGFR-Activ

Epidermal growth factor receptor (EGFR) activation by cytohesins - Structural Insights

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "EGFR-Activ" data sheet

The following table provides information about the project.

Coordinator
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF 

Organization address
address: UNIVERSITAETSSTRASSE 1
city: DUSSELDORF
postcode: 40225
website: www.uni-duesseldorf.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://etzkornlab.de/index.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-04   to  2017-05-03

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HEINRICH-HEINE-UNIVERSITAET DUESSELDORF DE (DUSSELDORF) coordinator 159˙460.00

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 Project objective

The epidermal growth factor receptor (EGFR) is a key player in many biological responses and its aberrant function is associated with numerous diseases, including a number of cancers. Despite the significant benefits of anti-EGFR agents in some tumours, many challenges remain in the improvement of EGFR-targeted therapies. This proposal targets cofactors in the EGFR signalling that, so far, were not exploited therapeutically and hence may not only contribute to the global effort in the understanding of this system but may also open new doors to the development of new therapeutic agents. The aim is to use Nuclear Magnetic Resonance (NMR) to obtain structural insights into EGFR activation covering three main aspects: i) modulation of activity by the transmembrane and juxtamembrane domains, ii) the role of the cell membrane and iii) the role of cytohesins in EGFR activation. For this, selected protein constructs will be prepared and their structure and interactions will be characterized. In parallel, new NMR methodology to improve the study of challenging biological samples, specifically EGFR, will be developed. The work plan will provide an innovative and multidisciplinary training covering different areas in Life Sciences and allow the researcher to experience work in an industrial environment through a secondment. We anticipate to obtain structural information that contributes to the global knowledge on these systems and to the discovery novel therapeutic agents. Moreover, the innovative methodologies that will be used in terms of the acquisition of multidimensional NMR experiments have the potential to change the way current investigation of challenging biological samples is done by NMR spectroscopy.

 Publications

year authors and title journal last update
List of publications.
2016 Thibault Viennet, Aldino Viegas, Arne Kuepper, Sabine Arens, Vladimir Gelev, Ognyan Petrov, Tom N. Grossmann, Henrike Heise, Manuel Etzkorn
Inside Cover: Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization (Angew. Chem. Int. Ed. 36/2016)
published pages: 10526-10526, ISSN: 1433-7851, DOI: 10.1002/anie.201606093
Angewandte Chemie International Edition 55/36 2019-07-24
2016 Aldino Viegas, Thibault Viennet, Manuel Etzkorn
The power, pitfalls and potential of the nanodisc system for NMR-based studies
published pages: , ISSN: 1431-6730, DOI: 10.1515/hsz-2016-0224
Biological Chemistry 2019-07-24
2016 Aldino Viegas, Thibault Viennet, Tsyr-Yan Yu, Frank Schumann, Wolfgang Bermel, Gerhard Wagner, Manuel Etzkorn
UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection
published pages: 9-15, ISSN: 0925-2738, DOI: 10.1007/s10858-015-0008-7
Journal of Biomolecular NMR 64/1 2019-07-24

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