Explore the words cloud of the EGFR-Activ project. It provides you a very rough idea of what is the project "EGFR-Activ" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||159˙460 €|
|EC max contribution||159˙460 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-05-04 to 2017-05-03|
Take a look of project's partnership.
|1||HEINRICH-HEINE-UNIVERSITAET DUESSELDORF||DE (DUSSELDORF)||coordinator||159˙460.00|
The epidermal growth factor receptor (EGFR) is a key player in many biological responses and its aberrant function is associated with numerous diseases, including a number of cancers. Despite the significant benefits of anti-EGFR agents in some tumours, many challenges remain in the improvement of EGFR-targeted therapies. This proposal targets cofactors in the EGFR signalling that, so far, were not exploited therapeutically and hence may not only contribute to the global effort in the understanding of this system but may also open new doors to the development of new therapeutic agents. The aim is to use Nuclear Magnetic Resonance (NMR) to obtain structural insights into EGFR activation covering three main aspects: i) modulation of activity by the transmembrane and juxtamembrane domains, ii) the role of the cell membrane and iii) the role of cytohesins in EGFR activation. For this, selected protein constructs will be prepared and their structure and interactions will be characterized. In parallel, new NMR methodology to improve the study of challenging biological samples, specifically EGFR, will be developed. The work plan will provide an innovative and multidisciplinary training covering different areas in Life Sciences and allow the researcher to experience work in an industrial environment through a secondment. We anticipate to obtain structural information that contributes to the global knowledge on these systems and to the discovery novel therapeutic agents. Moreover, the innovative methodologies that will be used in terms of the acquisition of multidimensional NMR experiments have the potential to change the way current investigation of challenging biological samples is done by NMR spectroscopy.
|year||authors and title||journal||last update|
Thibault Viennet, Aldino Viegas, Arne Kuepper, Sabine Arens, Vladimir Gelev, Ognyan Petrov, Tom N. Grossmann, Henrike Heise, Manuel Etzkorn
Inside Cover: Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization (Angew. Chem. Int. Ed. 36/2016)
published pages: 10526-10526, ISSN: 1433-7851, DOI: 10.1002/anie.201606093
|Angewandte Chemie International Edition 55/36||2019-07-24|
Aldino Viegas, Thibault Viennet, Manuel Etzkorn
The power, pitfalls and potential of the nanodisc system for NMR-based studies
published pages: , ISSN: 1431-6730, DOI: 10.1515/hsz-2016-0224
Aldino Viegas, Thibault Viennet, Tsyr-Yan Yu, Frank Schumann, Wolfgang Bermel, Gerhard Wagner, Manuel Etzkorn
UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection
published pages: 9-15, ISSN: 0925-2738, DOI: 10.1007/s10858-015-0008-7
|Journal of Biomolecular NMR 64/1||2019-07-24|
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