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eADAM SIGNED

Ultra-small electrochemical aptasensors for specific dopamine real-time monitoring

Total Cost €

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EC-Contrib. €

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Partnership

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Project "eADAM" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://pure.au.dk/portal/en/projects/horizon-2020-ultrasmall-electrochemical-aptasensors-for-specific-dopamine-realtime-monitoring
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 200˙194.00

Map

 Project objective

Nowadays, over 1.2 million people in Europe live with Parkinson’s disease (PD) considered as a complex disorder of unknown etiology, where an important number of cases are sporadic. In practice, the neurodegeneration associated with PD, also at the level of neurotransmitters (NT) misbalance, starts several years prior to the appearance of the cardinal symptoms. There are important evidences supporting that some environmental factors increase the risk of developing PD. Thus, there is the need of understanding their role and action mechanisms in order to develop therapeutic strategies and, even more important to minimize risks of PD development. The main aim of this project is to develop an ultra-small electroanalytical diagnostic platform for highly-specific real-time monitoring of NT, such as dopamine (DA). Several methods have been developed in order to address this issue, but in general they lack either specificity or high spatial/temporal resolution. In this project we propose to exploit the ability of nucleic acid aptamers to sensitively and selectively bind/catalytically transform DA and develop an ultra-small array platform for DA monitoring in small biological environments. The importance is that it will be used to measure nM/μs DA release from PC12 cells and drosophila flies, examine the molecular mechanisms of neuronal function/dysfunction, and further correlated them to particular PD risk factors. In a long-term perspective, the project aims microscopic sensors that may future be integrated with brain implants designed to restore local neuronal activity and/or NT release, such as deep brain stimulation electrodes, implanted to treat PD.

 Publications

year authors and title journal last update
List of publications.
2017 Isabel Álvarez-Martos, Elena E. Ferapontova
A DNA sequence obtained by replacement of the dopamine RNA aptamer bases is not an aptamer
published pages: 381-385, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2017.05.134
Biochemical and Biophysical Research Communications 489/4 2019-06-18
2018 Isabel Álvarez-Martos, Elena E. Ferapontova
“Negative electrocatalysis”-based specific analysis of dopamine at basal plane HOPG in the presence of structurally related catecholamines
published pages: 48-51, ISSN: 1388-2481, DOI: 10.1016/j.elecom.2018.02.019
Electrochemistry Communications 89 2019-06-18
2016 Isabel Álvarez-Martos, Andrey Kartashov, Elena E. Ferapontova
Electron Transfer in Methylene-Blue-Labeled G3 Dendrimers Tethered to Gold
published pages: 2270-2280, ISSN: 2196-0216, DOI: 10.1002/celc.201600417
ChemElectroChem 3/12 2019-06-18
2017 Isabel Álvarez-Martos, Faezeh Shahdost-fard, Elena E. Ferapontova
Wiring of heme enzymes by methylene-blue labeled dendrimers
published pages: 206-215, ISSN: 0013-4686, DOI: 10.1016/j.electacta.2017.07.161
Electrochimica Acta 249 2019-06-18

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