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Liver Bioengineering

Ex vivo Re-vascularization in Porcine Liver Bioengineering - A Critical First Step Towards Effective Transplantation of Bioengineered Livers

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "Liver Bioengineering" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD 

Organization address
address: AVENIDA SAN JUAN BOSCO 13
city: ZARAGOZA
postcode: 50009
website: www.iacs.aragon.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.iacs.es
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2017-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO ARAGONES DE CIENCIAS DE LA SALUD ES (ZARAGOZA) coordinator 158˙121.00

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 Project objective

Liver transplantation is currently the only proven therapy to extend life of patients with terminal liver disease. Organ bioengineering and regenerative medicine are promising new technologies that can help reduce the burden of liver shortage by increasing the number of organs available for transplantation. However, current bioengineered livers lack a functional vascular network that can readily allow their transplantation into a living host. Previous studies by the candidate have shown successful recellularization of acellular liver scaffolds using endothelial cells and hepatic cells in a perfusion bioreactor, creating a vascularized human liver organoid. However, its vascular network was unable to maintain vascular patency under constant blood flow for long periods of time. Hence, better understanding of how experimental cell seeding conditions of porcine liver scaffolds influence their re-vascularization efficiency is critical to achieve sustainable vascular patency after transplantation. In order to accomplish this, the impact of fluid flow pressure and the seeded cell number will be investigated in re-endothelialization efficiency of an acellular porcine liver scaffold. Furthermore, bioreactor pre-conditioning with fluid flow pressure ramping and sequential cycles of vascular growth and maturation will be used to induce re-vascularization, maturation, and enhanced function to potentially increase vascular patency. Finally, re-vascularized liver scaffolds will be transplanted into 5-10Kg pigs and short and long-term vascular patency will be investigated. Hence, the long-term objective of this project is to create a functional re-vascularized porcine liver scaffold, a critical first step towards the effective transplantation of bioengineered livers.

 Publications

year authors and title journal last update
List of publications.
2017 Ochando, Jordi; Charron, Dominique; Baptista, Pedro M.; Uygun, Basak E.
Immune responses to bioengineered organs
published pages: , ISSN: 1087-2418, DOI: 10.1097/MOT.0000000000000378.
Current Opinion in Organ Transplantation 1 2019-07-24
2018 Dipen Vyas, Pedro M. Baptista, Matthew Brovold, Emma Moran, Brandon Gaston, Chris Booth, Michael Samuel, Anthony Atala, Shay Soker
Self-assembled liver organoids recapitulate hepatobiliary organogenesis in vitro
published pages: 750-761, ISSN: 0270-9139, DOI: 10.1002/hep.29483
Hepatology 67/2 2019-07-24
2016 Pedro M. Baptista, Emma C. Moran, Dipen Vyas, Maria H. Ribeiro, Anthony Atala, Jessica L. Sparks, Shay Soker
Fluid Flow Regulation of Revascularization and Cellular Organization in a Bioengineered Liver Platform
published pages: 199-207, ISSN: 1937-3384, DOI: 10.1089/ten.TEC.2015.0334
Tissue Engineering Part C: Methods 22/3 2019-07-24

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The information about "LIVER BIOENGINEERING" are provided by the European Opendata Portal: CORDIS opendata.

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