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ACT against AMR

Abyssomicin C Truncated derivatives against Antimicrobial Resistance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "ACT against AMR" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.wallentingroup.com/natural-product-derivatives.html
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 185˙857.00

Map

 Project objective

This project aims to offer a solid solution to the dwindling effectiveness of antibiotics against infectious diseases caused by the development of antimicrobial resistant (AMR) bacteria. The core of this proposal is to implement an innovative synthesis-oriented strategy to access truncated derivatives of abyssomicin C, a natural product that has shown especially promising antimicrobial activity against the most common strains of antimicrobial resistant bacteria. The multiple routes proposed for the synthesis of the truncated core scaffold are short, robust and amenable for many different variations. This will open up for the possibility to easily synthesise a library of differently adorned abyssomicin C truncated analogues whose antimicrobial activity will be evaluated. Structure activity relationship (SAR) studies aided by computational modeling will be used as an integrated action in the identification of new potent antimicrobial agents. The complementary expertise of the applicant, the host laboratories and the leading experts that will collaborate within this project will be crucial for the realization of all aspects of this multifaceted project. The achievement of the project goals will have a deep impact not only in the scientific community but also on the healthcare systems in Europe and globally. This EF postdoctoral training proposal will represent a unique opportunity to the candidate to expand his scientific network in both the academia and the industry, greatly broaden his spheres of action, strengthening his professional maturity.

 Publications

year authors and title journal last update
List of publications.
2017 Fredrik Pettersson, Giulia Bergonzini, Carlo Cassani, Carl-Johan Wallentin
Redox Neutral Dual Functionalization of Electron Deficient Alkenes
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201701589
Chemistry - A European Journal 2019-07-24
2016 Giulia Bergonzini, Carlo Cassani, Haldor Lorimer-Olsson, Johanna Hörberg, Carl-Johan Wallentin
Visible-Light-Mediated Photocatalytic Difunctionalization of Olefins by Radical Acylarylation and Tandem Acylation/Semipinacol Rearrangement
published pages: 3292-3295, ISSN: 0947-6539, DOI: 10.1002/chem.201504985
Chemistry - A European Journal 22/10 2019-07-24
2015 Giulia Bergonzini, Carlo Cassani, Carl-Johan Wallentin
Acyl Radicals from Aromatic Carboxylic Acids by Means of Visible-Light Photoredox Catalysis
published pages: 14066-14069, ISSN: 1433-7851, DOI: 10.1002/anie.201506432
Angewandte Chemie International Edition 54/47 2019-07-24
2016 Carlo Cassani, Giulia Bergonzini, Carl-Johan Wallentin
Active Species and Mechanistic Pathways in Iron-Catalyzed C–C Bond-Forming Cross-Coupling Reactions
published pages: 1640-1648, ISSN: 2155-5435, DOI: 10.1021/acscatal.5b02441
ACS Catalysis 6/3 2019-07-24

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The information about "ACT AGAINST AMR" are provided by the European Opendata Portal: CORDIS opendata.

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