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An Automatic Microfluidic Device Assembly System

Total Cost €


EC-Contrib. €






Project "uDAS" data sheet

The following table provides information about the project.


Organization address
postcode: 52900

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 150˙000.00


 Project objective

Microfluidic systems, in general, have proven important platforms for biomedical assays. These systems benefit from reduced requirements for expensive reagents, short analysis times, and portability. Although microfluidic systems are convenient platforms, their use in the life sciences is still limited mainly due to the high-level fabrication expertise required for construction.

Integrated microfluidics is one of the most sophisticated three-dimensional (multi layer) solution. It requires soft lithography (PDMS based chips), for production of high complexity microfluidic systems (multiple serial or parallel processes). Integrated microfluidics in particular is almost non-existent in the industry due to the low yield and uncontrolled production process.

My ERC project (MUDLOC-2012) is to develop a microfluidic platform for multidimensional protein array analysis. It uses complex multilayer microfluidic devices that consist of 2 PDMS layers and a glass microarray. The integrated microfluidics system contains thousands of micromechanical valves in micrometer dimensions, controlling thousands of parallel reactions. Our research demands production of hundreds of such devices.

We, as all others who produce integrated microfluidics, suffered from frustrating low yield (15%). In order to improve fabrication yield and to fabricate devices with increased density, we designed and manufactured, a first of its kind, full production process sequence, semi automatic Microfluidic Device Assembly System (µDAS). This resulted in a direct increase of device complexity and yield (85%) over the last half year.

The 2nd generation automated µDAS prototype will become a generic assembly tool for soft lithography. µDAS will enable a critical production standard and process control, which will pave the road for significant penetration of complex integrated microfluidics technology into both academia and industry.


year authors and title journal last update
List of publications.
2016 Dorit Avirahami, Sarit Kipper, Yair Glick, Ludmila Frolov, Ortal Guy, Efrat Michaely
ON-The-Fly Microfluidic Device Assembly
published pages: , ISSN: , DOI:
EMBL Conference Microfluidics 2016 1 every two years 2019-07-24
2017 Sarit Kipper, Ludmila Frolov, Ortal Guy, Michal Pellach, Yair Glick, Asaf Malichi, Binyamin A. Knisbacher, Efrat Barbiro-Michaely, Dorit Avrahami, Yehuda Yavets-Chen, Erez Y. Levanon, Doron Gerber
Control and automation of multilayered integrated microfluidic device fabrication
published pages: 557-566, ISSN: 1473-0197, DOI: 10.1039/C6LC01534D
Lab Chip 17/3 2019-07-24
2016 Glick Y., Ben-ari Y., Schwartz N., Nevenzal H., Ronen M., Kipper S., Golodnitsky R., Chen D., Avrahami D., Barbiro-michaely E., Gerber D.
Alignment in multilayer microfluidics device A stumbling block
published pages: , ISSN: , DOI:

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