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MyNano SIGNED

Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients

Total Cost €

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EC-Contrib. €

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Partnership

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 MyNano project word cloud

Explore the words cloud of the MyNano project. It provides you a very rough idea of what is the project "MyNano" about.

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Project "MyNano" data sheet

The following table provides information about the project.

Coordinator
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE 

Organization address
address: CALLE EDUARDO PRIMO YUFERA 3
city: VALENCIA
postcode: 46012
website: http://www.cipf.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://vicentresearchlab.com
 Total cost 1˙724˙168 €
 EC max contribution 1˙724˙168 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE ES (VALENCIA) coordinator 1˙724˙168.00

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 Project objective

Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory patients and reduced drug-related toxicity. However, there is a growing concern on patient variability regarding tumor patho-physiology that underlie successful therapeutic outcome. Specific biomarkers are required to select those patients most likely to show good clinical response to these therapies. The objective of MyNano is to engineer polymer-based combination therapies designed to treat metastatic breast cancer in a patient personalised manner. Therefore, novel multicomponent polymer conjugates with precise control over size, shape, solution conformation, multifunctionality and bioresponsiveness will be obtained while in parallel their structure activity relationships to underlying proposed mechanisms of action in clinically relevant models will be studied. Polyglutamates obtained by controlled polymerisation and self-assembly strategies will be the carriers. Primary breast cancer patient tissue will be used to generate cell and in vivo models representing different clinical molecular subtypes. MyNano will also investigate new combination strategies using current treatments together with inhibitors of tumor-derived exosome release pathways, phenomenon related to metastasis and resistance mechanisms. The aim is to provide a novel methodological approach that would allow by reiterative design to optimise the design of the next generation nanoconjugates for the treatment of specific metastatic cancer clinical subtypes. MyNano will be a breakthrough as it introduces a paradigm shift in the strategy to design nanomedicines in areas of unmet clinical need.

 Publications

year authors and title journal last update
List of publications.
2020 O. Zagorodko, V. J. Nebot, M. J. Vicent
The generation of stabilized supramolecular nanorods from star-shaped polyglutamates
published pages: 1220-1229, ISSN: 1759-9954, DOI: 10.1039/C9PY01442J
Polymer Chemistry 11/6 2020-02-19
2018 Fernanda Rodriguez-Otormin, Aroa Duro-Castano, Inmaculada Conejos-Sánchez, María J. Vicent
Envisioning the future of polymer therapeutics for brain disorders
published pages: e1532, ISSN: 1939-5116, DOI: 10.1002/wnan.1532
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2019-06-07
2017 Aroa Duro-Castano, Elena Gallon, Caitlin Decker, María J. Vicent
Modulating angiogenesis with integrin-targeted nanomedicines
published pages: 101-119, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.05.008
Advanced Drug Delivery Reviews 119 2019-06-07
2017 Aroa Duro-Castano, Vicent J. Nebot, Amaya Niño-Pariente, Ana Armiñán, Juan J. Arroyo-Crespo, Alison Paul, Natalia Feiner-Gracia, Lorenzo Albertazzi, María J. Vicent
Capturing “Extraordinary” Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design
published pages: 1702888, ISSN: 0935-9648, DOI: 10.1002/adma.201702888
Advanced Materials 29/39 2019-06-07
2018 Juan J. Arroyo-Crespo, Coralie Deladriere, Vicent J. Nebot, David Charbonnier, Esther Masiá, Alison Paul, Craig James, Ana Armiñán, María J. Vicent
Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate
published pages: 1800931, ISSN: 1616-301X, DOI: 10.1002/adfm.201800931
Advanced Functional Materials 28/22 2019-06-07
2016 Oleksandr Zagorodko, Juan José Arroyo-Crespo, Vicent J. Nebot, María J. Vicent
Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges
published pages: , ISSN: 1616-5187, DOI: 10.1002/mabi.201600316
Macromolecular Bioscience 2019-06-07
2015 A. Duro-Castano, J. Movellan, M. J. Vicent
Smart branched polymer drug conjugates as nano-sized drug delivery systems
published pages: 1321-1334, ISSN: 2047-4830, DOI: 10.1039/c5bm00166h
Biomater. Sci. 3/10 2019-06-07
2016 Amaya Nino-Pariente, Vicent Nebot, Maria Vicent
Relevant Physicochemical Descriptors of “Soft Nanomedicines” to Bypass Biological Barriers
published pages: 1274-1291, ISSN: 1381-6128, DOI: 10.2174/1381612822666151216152143
Current Pharmaceutical Design 22/9 2019-06-07
2018 Ana Armiñán, Martina Palomino-Schätzlein, Coralie Deladriere, Juan J. Arroyo-Crespo, Sonia Vicente-Ruiz, María Jesús Vicent, Antonio Pineda-Lucena
Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models
published pages: 144-153, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.02.015
Biomaterials 2019-06-07
2019 Juan J. Arroyo‐Crespo, Ana Armiñán, David Charbonnier, Coralie Deladriere, Martina Palomino‐Schätzlein, Rubén Lamas‐Domingo, Jerónimo Forteza, Antonio Pineda‐Lucena, María J. Vicent
Characterization of triple‐negative breast cancer preclinical models provides functional evidence of metastatic progression
published pages: , ISSN: 0020-7136, DOI: 10.1002/ijc.32270
International Journal of Cancer 2019-05-22
2018 Juan J. Arroyo-Crespo, Ana Armiñán, David Charbonnier, Leandro Balzano-Nogueira, Francisco Huertas-López, Cristina Martí, Sonia Tarazona, Jerónimo Forteza, Ana Conesa, María J. Vicent
Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment
published pages: 8-21, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.09.023
Biomaterials 186 2019-04-18

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