Explore the words cloud of the MyNano project. It provides you a very rough idea of what is the project "MyNano" about.
The following table provides information about the project.
FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE
|Coordinator Country||Spain [ES]|
|Total cost||1˙724˙168 €|
|EC max contribution||1˙724˙168 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
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|1||FUNDACION DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPEFELIPE||ES (VALENCIA)||coordinator||1˙724˙168.00|
Research on anticancer therapies has provided little progress towards improved survival rates for patients with metastatic disease. The intrinsic advantages of polymer conjugates can be optimised to rationally design targeted combination therapies, concept I pioneered that allows enhanced therapeutic efficiency. Early clinical trials involving conjugates showed activity in chemotherapy refractory patients and reduced drug-related toxicity. However, there is a growing concern on patient variability regarding tumor patho-physiology that underlie successful therapeutic outcome. Specific biomarkers are required to select those patients most likely to show good clinical response to these therapies. The objective of MyNano is to engineer polymer-based combination therapies designed to treat metastatic breast cancer in a patient personalised manner. Therefore, novel multicomponent polymer conjugates with precise control over size, shape, solution conformation, multifunctionality and bioresponsiveness will be obtained while in parallel their structure activity relationships to underlying proposed mechanisms of action in clinically relevant models will be studied. Polyglutamates obtained by controlled polymerisation and self-assembly strategies will be the carriers. Primary breast cancer patient tissue will be used to generate cell and in vivo models representing different clinical molecular subtypes. MyNano will also investigate new combination strategies using current treatments together with inhibitors of tumor-derived exosome release pathways, phenomenon related to metastasis and resistance mechanisms. The aim is to provide a novel methodological approach that would allow by reiterative design to optimise the design of the next generation nanoconjugates for the treatment of specific metastatic cancer clinical subtypes. MyNano will be a breakthrough as it introduces a paradigm shift in the strategy to design nanomedicines in areas of unmet clinical need.
|year||authors and title||journal||last update|
O. Zagorodko, V. J. Nebot, M. J. Vicent
The generation of stabilized supramolecular nanorods from star-shaped polyglutamates
published pages: 1220-1229, ISSN: 1759-9954, DOI: 10.1039/C9PY01442J
|Polymer Chemistry 11/6||2020-02-19|
Fernanda Rodriguez-Otormin, Aroa Duro-Castano, Inmaculada Conejos-SÃ¡nchez, MarÃa J. Vicent
Envisioning the future of polymer therapeutics for brain disorders
published pages: e1532, ISSN: 1939-5116, DOI: 10.1002/wnan.1532
|Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology||2019-06-07|
Aroa Duro-Castano, Elena Gallon, Caitlin Decker, MarÃa J. Vicent
Modulating angiogenesis with integrin-targeted nanomedicines
published pages: 101-119, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.05.008
|Advanced Drug Delivery Reviews 119||2019-06-07|
Aroa Duro-Castano, Vicent J. Nebot, Amaya NiÃ±o-Pariente, Ana ArmiÃ±Ã¡n, Juan J. Arroyo-Crespo, Alison Paul, Natalia Feiner-Gracia, Lorenzo Albertazzi, MarÃa J. Vicent
Capturing â€œExtraordinaryâ€ Soft-Assembled Charge-Like Polypeptides as a Strategy for Nanocarrier Design
published pages: 1702888, ISSN: 0935-9648, DOI: 10.1002/adma.201702888
|Advanced Materials 29/39||2019-06-07|
Juan J. Arroyo-Crespo, Coralie Deladriere, Vicent J. Nebot, David Charbonnier, Esther MasiÃ¡, Alison Paul, Craig James, Ana ArmiÃ±Ã¡n, MarÃa J. Vicent
Anticancer Activity Driven by Drug Linker Modification in a Polyglutamic Acid-Based Combination-Drug Conjugate
published pages: 1800931, ISSN: 1616-301X, DOI: 10.1002/adfm.201800931
|Advanced Functional Materials 28/22||2019-06-07|
Oleksandr Zagorodko, Juan JosÃ© Arroyo-Crespo, Vicent J. Nebot, MarÃa J. Vicent
Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges
published pages: , ISSN: 1616-5187, DOI: 10.1002/mabi.201600316
A. Duro-Castano, J. Movellan, M. J. Vicent
Smart branched polymer drug conjugates as nano-sized drug delivery systems
published pages: 1321-1334, ISSN: 2047-4830, DOI: 10.1039/c5bm00166h
|Biomater. Sci. 3/10||2019-06-07|
Amaya Nino-Pariente, Vicent Nebot, Maria Vicent
Relevant Physicochemical Descriptors of â€œSoft Nanomedicinesâ€ to Bypass Biological Barriers
published pages: 1274-1291, ISSN: 1381-6128, DOI: 10.2174/1381612822666151216152143
|Current Pharmaceutical Design 22/9||2019-06-07|
Ana ArmiÃ±Ã¡n, Martina Palomino-SchÃ¤tzlein, Coralie Deladriere, Juan J. Arroyo-Crespo, Sonia Vicente-Ruiz, MarÃa JesÃºs Vicent, Antonio Pineda-Lucena
Metabolomics facilitates the discrimination of the specific anti-cancer effects of free- and polymer-conjugated doxorubicin in breast cancer models
published pages: 144-153, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.02.015
Juan J. Arroyoâ€Crespo, Ana ArmiÃ±Ã¡n, David Charbonnier, Coralie Deladriere, Martina Palominoâ€SchÃ¤tzlein, RubÃ©n Lamasâ€Domingo, JerÃ³nimo Forteza, Antonio Pinedaâ€Lucena, MarÃa J. Vicent
Characterization of tripleâ€negative breast cancer preclinical models provides functional evidence of metastatic progression
published pages: , ISSN: 0020-7136, DOI: 10.1002/ijc.32270
|International Journal of Cancer||2019-05-22|
Juan J. Arroyo-Crespo, Ana ArmiÃ±Ã¡n, David Charbonnier, Leandro Balzano-Nogueira, Francisco Huertas-LÃ³pez, Cristina MartÃ, Sonia Tarazona, JerÃ³nimo Forteza, Ana Conesa, MarÃa J. Vicent
Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment
published pages: 8-21, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.09.023
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