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FRINGE SIGNED

Fluorescence and Reactive oxygen Intermediates by Neutron Generated electronic Excitation as a foundation for radically new cancer therapies

Total Cost €

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EC-Contrib. €

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Partnership

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 FRINGE project word cloud

Explore the words cloud of the FRINGE project. It provides you a very rough idea of what is the project "FRINGE" about.

medical    curative    activated    lying    marginal    physicists    foundations    deep    metal    disciplines    cell    agents    cells    beam    scientific    suffer    exactly    penetration    gadolinium    compromised    pss    tuned    immunogenic    difficult    tumour    oncologists    lack    sufficient    team    treat    therapies    modality    combination    externally    genuinely    death    ps    incoming    join    chemists    renowned    gd    advantages    generate    therapeutic    photomedical    photochemists    excitation    mutagenic    theranostic    experts    electron    transfer    blood    agent    neutrons    quantum    world    contain    hybrid    interdisciplinary    kill    interaction    combine    cancers    brain    metastasis    synthetic    lay    preferentially    act    causing    nuclear    centres    accumulate    aggressive    therapy    photosensitisers    designed    emission    neutron    occult    vaccine    cancer    photobiologists    confirmed    imaging    experimental    heart    specificity    chemical    rates    magnetic    reactive    breakthrough    eliminate    contrast    fluorescence    radio    barrier    survival    radiation    forces    ambient    tumours    proof    limited    tissue    oxygen    mainly    concomitant    energy    resonance    light    species    insufficient    fringe   

Project "FRINGE" data sheet

The following table provides information about the project.

Coordinator
OSLO UNIVERSITETSSYKEHUS HF 

Organization address
address: KIRKEVEIEN 166 TARNBYGGET
city: OSLO
postcode: 450
website: http://www.oslo-universitetssykehus.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 3˙979˙485 €
 EC max contribution 3˙979˙485 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) coordinator 898˙118.00
2    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EL (AGIA PARASKEVI) participant 719˙687.00
3    INSTITUTT FOR ENERGITEKNIKK NO (KJELLER) participant 559˙875.00
4    SYNTHETICA AS NO (OSLO) participant 446˙875.00
5    UNIVERSITAT POLITECNICA DE VALENCIA ES (VALENCIA) participant 384˙375.00
6    VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE CZ (PRAHA) participant 382˙500.00
7    UNIVERSITAT DE GIRONA ES (GIRONA) participant 336˙250.00
8    ACCELOPMENT AG CH (ZUERICH) participant 251˙803.00

Map

 Project objective

Deep lying tumours like aggressive brain cancer remain very difficult to treat and existing therapies offer only marginal increase in survival rates. In the case of photomedical therapies they are very effective, but mainly limited by their insufficient depth of light penetration into tissue. Current neutron-based therapies have sufficient penetration depth but suffer from lack of cancer specificity. In FRINGE we propose a genuinely new hybrid-technology. At its heart are chemical agents (photosensitisers - PS) which preferentially accumulate in the tumours especially in brain cancers where the blood brain barrier is compromised. The PSs designed for FRINGE will contain metal centres like Gadolinium (Gd), to enable interaction with incoming neutrons and facilitate the transfer of neutron energy into electron excitation of the PS, confirmed by concomitant fluorescence emission. Interaction with ambient oxygen will generate reactive oxygen species which will kill the tumour cells. The main scientific breakthrough of this project will be to establish experimental proof-of-principle of this novel neutron-activated therapy. FRINGE will combine the advantages of photomedical therapies (no mutagenic radiation) with the advantages of neutron-based therapies (large penetration depth). The externally-applied neutron beam can be energy-tuned to become therapeutic exactly at the depth of the tumour. Exploiting Gd as a contrast agent, FRINGE can also become a theranostic modality by use of magnetic resonance imaging. FRINGE has the potential of causing immunogenic cell death to cancers which could eliminate occult metastasis and act as a ‘cancer vaccine’. The highly interdisciplinary project team comprises world renowned experts from a unique combination of disciplines: Nuclear physicists, synthetic chemists, photochemists, photobiologists, medical physicists, quantum chemists and radio-oncologists will join forces to lay the foundations for a novel, curative cancer therapy.

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The information about "FRINGE" are provided by the European Opendata Portal: CORDIS opendata.

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