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FRINGE SIGNED

Fluorescence and Reactive oxygen Intermediates by Neutron Generated electronic Excitation as a foundation for radically new cancer therapies

Total Cost €

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EC-Contrib. €

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Partnership

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FRINGE project word cloud

Explore the words cloud of the FRINGE project. It provides you a very rough idea of what is the project "FRINGE" about.

mutagenic photobiologists lack combination emission sufficient contrast pss accumulate interaction lay confirmed transfer hybrid fringe genuinely chemists energy join modality immunogenic ambient photochemists imaging tumour causing death disciplines mainly gadolinium insufficient renowned photomedical generate resonance specificity agents chemical vaccine gd medical photosensitisers reactive ps cell externally blood neutrons interdisciplinary fluorescence heart metastasis designed magnetic agent difficult act eliminate treat physicists brain neutron occult experts cancer tissue therapeutic concomitant therapy deep compromised oxygen contain world aggressive preferentially suffer rates electron proof advantages tumours foundations barrier scientific tuned combine survival incoming kill excitation penetration lying cells limited radio breakthrough nuclear beam therapies cancers team light marginal oncologists activated exactly experimental species metal quantum synthetic theranostic forces curative centres radiation

Project "FRINGE" data sheet

The following table provides information about the project.

Coordinator	OSLO UNIVERSITETSSYKEHUS HF Organization address address: KIRKEVEIEN 166 TARNBYGGET city: OSLO postcode: 450 website: http://www.oslo-universitetssykehus.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Total cost	3˙979˙485 €
EC max contribution	3˙979˙485 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2018-2019-2020-01
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-05-01 to 2023-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OSLO UNIVERSITETSSYKEHUS HF OSLO UNIVERSITETSSYKEHUS HF Organization address address: KIRKEVEIEN 166 TARNBYGGET city: OSLO postcode: 450 website: http://www.oslo-universitetssykehus.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	coordinator	898˙118.00
2	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Organization address address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET city: AGIA PARASKEVI postcode: 15341 website: www.demokritos.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (AGIA PARASKEVI)	participant	719˙687.00
3	INSTITUTT FOR ENERGITEKNIKK INSTITUTT FOR ENERGITEKNIKK Organization address address: Instituttveien 18 city: KJELLER postcode: 2027 website: http://www.ife.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (KJELLER)	participant	559˙875.00
4	SYNTHETICA AS SYNTHETICA AS Organization address address: 4 ETASJE SILURVEIEN 2B city: OSLO postcode: 380 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	446˙875.00
5	UNIVERSITAT POLITECNICA DE VALENCIA UNIVERSITAT POLITECNICA DE VALENCIA Organization address address: CAMINO DE VERA SN EDIFICIO 3A city: VALENCIA postcode: 46022 website: www.upv.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	384˙375.00
6	VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE Organization address address: TECHNICKA 5 city: PRAHA postcode: 166 28 website: www.vscht.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA)	participant	382˙500.00
7	UNIVERSITAT DE GIRONA UNIVERSITAT DE GIRONA Organization address address: PLACA SANT DOMENEC 3 city: GIRONA postcode: 17004 website: www.udg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GIRONA)	participant	336˙250.00
8	ACCELOPMENT AG ACCELOPMENT AG Organization address address: SEEFELDSTRASSE 198 city: ZUERICH postcode: 8008 website: www.accelopment.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	251˙803.00

Map

Project objective

Deep lying tumours like aggressive brain cancer remain very difficult to treat and existing therapies offer only marginal increase in survival rates. In the case of photomedical therapies they are very effective, but mainly limited by their insufficient depth of light penetration into tissue. Current neutron-based therapies have sufficient penetration depth but suffer from lack of cancer specificity. In FRINGE we propose a genuinely new hybrid-technology. At its heart are chemical agents (photosensitisers - PS) which preferentially accumulate in the tumours especially in brain cancers where the blood brain barrier is compromised. The PSs designed for FRINGE will contain metal centres like Gadolinium (Gd), to enable interaction with incoming neutrons and facilitate the transfer of neutron energy into electron excitation of the PS, confirmed by concomitant fluorescence emission. Interaction with ambient oxygen will generate reactive oxygen species which will kill the tumour cells. The main scientific breakthrough of this project will be to establish experimental proof-of-principle of this novel neutron-activated therapy. FRINGE will combine the advantages of photomedical therapies (no mutagenic radiation) with the advantages of neutron-based therapies (large penetration depth). The externally-applied neutron beam can be energy-tuned to become therapeutic exactly at the depth of the tumour. Exploiting Gd as a contrast agent, FRINGE can also become a theranostic modality by use of magnetic resonance imaging. FRINGE has the potential of causing immunogenic cell death to cancers which could eliminate occult metastasis and act as a ‘cancer vaccine’. The highly interdisciplinary project team comprises world renowned experts from a unique combination of disciplines: Nuclear physicists, synthetic chemists, photochemists, photobiologists, medical physicists, quantum chemists and radio-oncologists will join forces to lay the foundations for a novel, curative cancer therapy.

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