Opendata, web and dolomites

FRINGE SIGNED

Fluorescence and Reactive oxygen Intermediates by Neutron Generated electronic Excitation as a foundation for radically new cancer therapies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 FRINGE project word cloud

Explore the words cloud of the FRINGE project. It provides you a very rough idea of what is the project "FRINGE" about.

excitation    experts    magnetic    preferentially    chemists    eliminate    aggressive    ambient    chemical    lack    combination    rates    hybrid    specificity    activated    combine    agent    penetration    tumour    cancers    confirmed    immunogenic    incoming    radiation    blood    foundations    experimental    kill    difficult    oncologists    therapeutic    join    neutron    accumulate    exactly    lay    tuned    cells    cell    fluorescence    heart    concomitant    imaging    physicists    curative    limited    theranostic    sufficient    radio    team    death    brain    photomedical    renowned    occult    breakthrough    nuclear    species    causing    gadolinium    photosensitisers    fringe    tumours    externally    medical    generate    proof    quantum    photobiologists    compromised    vaccine    mutagenic    lying    light    photochemists    pss    therapies    contain    beam    ps    act    forces    centres    energy    oxygen    insufficient    interdisciplinary    genuinely    synthetic    designed    marginal    therapy    transfer    neutrons    disciplines    treat    advantages    barrier    suffer    world    metal    metastasis    scientific    resonance    survival    emission    agents    tissue    gd    deep    reactive    electron    interaction    contrast    mainly    cancer    modality   

Project "FRINGE" data sheet

The following table provides information about the project.

Coordinator
OSLO UNIVERSITETSSYKEHUS HF 

Organization address
address: KIRKEVEIEN 166 TARNBYGGET
city: OSLO
postcode: 450
website: http://www.oslo-universitetssykehus.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Total cost 3˙979˙485 €
 EC max contribution 3˙979˙485 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2018-2019-2020-01
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2023-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) coordinator 898˙118.00
2    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EL (AGIA PARASKEVI) participant 719˙687.00
3    INSTITUTT FOR ENERGITEKNIKK NO (KJELLER) participant 559˙875.00
4    SYNTHETICA AS NO (OSLO) participant 446˙875.00
5    UNIVERSITAT POLITECNICA DE VALENCIA ES (VALENCIA) participant 384˙375.00
6    VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE CZ (PRAHA) participant 382˙500.00
7    UNIVERSITAT DE GIRONA ES (GIRONA) participant 336˙250.00
8    ACCELOPMENT AG CH (ZUERICH) participant 251˙803.00

Map

 Project objective

Deep lying tumours like aggressive brain cancer remain very difficult to treat and existing therapies offer only marginal increase in survival rates. In the case of photomedical therapies they are very effective, but mainly limited by their insufficient depth of light penetration into tissue. Current neutron-based therapies have sufficient penetration depth but suffer from lack of cancer specificity. In FRINGE we propose a genuinely new hybrid-technology. At its heart are chemical agents (photosensitisers - PS) which preferentially accumulate in the tumours especially in brain cancers where the blood brain barrier is compromised. The PSs designed for FRINGE will contain metal centres like Gadolinium (Gd), to enable interaction with incoming neutrons and facilitate the transfer of neutron energy into electron excitation of the PS, confirmed by concomitant fluorescence emission. Interaction with ambient oxygen will generate reactive oxygen species which will kill the tumour cells. The main scientific breakthrough of this project will be to establish experimental proof-of-principle of this novel neutron-activated therapy. FRINGE will combine the advantages of photomedical therapies (no mutagenic radiation) with the advantages of neutron-based therapies (large penetration depth). The externally-applied neutron beam can be energy-tuned to become therapeutic exactly at the depth of the tumour. Exploiting Gd as a contrast agent, FRINGE can also become a theranostic modality by use of magnetic resonance imaging. FRINGE has the potential of causing immunogenic cell death to cancers which could eliminate occult metastasis and act as a ‘cancer vaccine’. The highly interdisciplinary project team comprises world renowned experts from a unique combination of disciplines: Nuclear physicists, synthetic chemists, photochemists, photobiologists, medical physicists, quantum chemists and radio-oncologists will join forces to lay the foundations for a novel, curative cancer therapy.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "FRINGE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "FRINGE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.2.1.)

BRIEFING (2018)

Bridging the FET Innovation Gap

Read More  

ATEMPGRAD (2019)

Analysing Temperature Effects with a Mobile and Precise Gradient Device

Read More  

NanoBRIGHT (2019)

BRInGing nano-pHoTonics into the brain

Read More