Explore the words cloud of the FAtoUnFRAGILITY project. It provides you a very rough idea of what is the project "FAtoUnFRAGILITY" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||1˙462˙383 €|
|EC max contribution||1˙462˙383 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2020-05-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||1˙462˙383.00|
Originally described by cytogeneticists, common fragile sites (CFSs) are chromosomal regions known for their susceptibility to break and rearrange aberrantly, thus altering the expression of genes located therein. CFS instability is associated with tumor development and pathogenic copy number variations. Recent advances have significantly contributed to dissect the molecular bases of CFS instability, yet a unifying model for their unique breakage propensity has not been determined. Fanconi anemia (FA) is a chromosomal instability syndrome featuring congenital abnormalities, bone marrow failure and cancer predisposition, characterized by an increased CFS fragility. FA is thus an ideal model to understand the mechanisms underpinning CFS instability and the mechanistic link between CFS instability and the pathogenesis of disease phenotypes. I propose to use FA cellular models to examine the molecular events leading to CFS instability, and FA mouse models to investigate the consequences of deletions, amplifications or rearrangements involving CFSs on the expression of genes regulating critical signal transduction pathways involved in cell survival, proliferation, and differentiation. Exploring these mechanisms can lead to the development of chemopreventive or therapeutic strategies targeting aberrant gene expression or pathological pathways.
|year||authors and title||journal||last update|
Philippe Fernandes, Benoit Miotto, Claude Saint-Ruf, Viola NÃ¤hse, Silvia Ravera, Enrico Cappelli, Valeria Naim
FANCD2 tunes the UPR preventing mitochondrial stress--induced common fragile site instability
published pages: , ISSN: , DOI: 10.1101/808915
Michalis Fragkos, Viviana Barra, Tom Egger, Benoit Bordignon, Delphine Lemacon, Valeria Naim and Arnaud Coquelle
Dicer prevents genome instability in response to replication stress
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.27034
Michalis Fragkos, Valeria Naim
Rescue from replication stress during mitosis
published pages: 1-21, ISSN: 1538-4101, DOI: 10.1080/15384101.2017.1288322
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The information about "FATOUNFRAGILITY" are provided by the European Opendata Portal: CORDIS opendata.