LONGHEART SIGNED
Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure
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0EC-Contrib. €
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Project "LONGHEART" data sheet
The following table provides information about the project.
| Coordinator |
MEDIZINISCHE HOCHSCHULE HANNOVER
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙816˙250 € |
| EC max contribution | 1˙816˙250 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-06-01 to 2020-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MEDIZINISCHE HOCHSCHULE HANNOVER | DE (HANNOVER) | coordinator | 1˙816˙250.00 |
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Project objective
Despite clinical advances, diseases of the cardiovascular system are the most common cause of morbidity and mortality in the EU with currently 50 million people suffering from heart failure. These important challenges call for a better understanding of underlying mechanisms to enable development of innovative, effective diagnostic and therapeutic strategies for heart failure. Cardiac stress such as myocardial infarction or hypertension leads to cellular “remodeling” of the left ventricle resulting in heart failure. Protein-coding genes originate from only 1.5% of the genome, whereas the larger remaining portion is often transcribed to non-coding RNAs, of which functional importance is still ill understood. We pioneered a role of small microRNAs as diagnostics and therapeutic targets for heart failure (Nature, 2008; Nature Comm, 2012, J Clin Invest, 2014). We now will focus on the larger fraction of long non-coding RNAs (lncRNAs) and their functional roles, as well as diagnostic and therapeutic use in heart failure. The proposal has the following interconnected objectives: a) identify novel functional relevant cardiac remodeling-associated lncRNAs; b) characterise key lncRNA cardiac targetomes; c) investigate lncRNA-paracrine mechanisms and the diagnostic and prognostic potential of cardiac-derived extracellular lncRNAs using large clinical cohorts; and d) discover their therapeutic potential to prevent cardiac remodeling in clinically relevant animal models. Innovative molecular and cell-based methods, a unique lncRNA-shRNA library, genetic animal models and availability of large clinical biobanks will form the basis for a successful strategy. LONGHEART will lead to ground-breaking new insight into the role of lncRNAs in the heart. These findings will firmly establish lncRNA-based mechanisms to identify fundamentally novel diagnostic and therapeutic entry points for a most serious clinical important disorder in dire need for new diagnostic and therapeutic paradigms.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Christian Bär, Thomas Thum Changing Direction published pages: 1393-1395, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.310316 |
Circulation Research 120/9 | 2019-06-06 |
| 2015 |
Sandra C. Mayer, Ralf Gilsbach, Sebastian Preissl, Elsa Beatriz Monroy Ordonez, Tilman Schnick, Nadine Beetz, Achim Lother, Carolin Rommel, Hannah Ihle, Heiko Bugger, Frank Rühle, Andrea Schrepper, Michael Schwarzer, Claudia Heilmann, Ulrike Bönisch, Shashi Kumar Gupta, Jochen Wilpert, Oliver Kretz, Dominik von Elverfeldt, Joachim Orth, Klaus Aktories, Friedhelm Beyersdorf, Christoph Bode, Brigitte Stiller, Markus Krüger, Thomas Thum, Torsten Doenst, Monika Stoll, Lutz Hein Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart FailureNovelty and Significance published pages: 622-633, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.115.306721 |
Circulation Research 117/7 | 2019-06-06 |
| 2017 |
Maria-Teresa Piccoli, Shashi Kumar Gupta, Janika Viereck, Ariana Foinquinos, Sabine Samolovac, Freya Luise Kramer, Ankita Garg, Janet Remke, Karina Zimmer, Sandor Batkai, Thomas Thum Inhibition of the Cardiac Fibroblast–Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic DysfunctionNovelty and Significance published pages: 575-583, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.310624 |
Circulation Research 121/5 | 2019-06-06 |
| 2017 |
Janika Viereck, Thomas Thum Long Noncoding RNAs in Pathological Cardiac Remodeling published pages: 262-264, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.310174 |
Circulation Research 120/2 | 2019-06-06 |
| 2017 |
Serge Masson, Sandor Batkai, Julia Beermann, Christian Bär, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.961 |
European Journal of Heart Failure | 2019-06-06 |
| 2017 |
Ke Xiao, Thomas Thum Exosomal MicroRNAs Released by Pediatric Cardiac Progenitor Cells published pages: 607-609, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.310443 |
Circulation Research 120/4 | 2019-06-06 |
| 2017 |
Cinzia Perrino, Albert-Laszló Barabási, Gianluigi Condorelli, Sean Michael Davidson, Leon De Windt, Stefanie Dimmeler, Felix Benedikt Engel, Derek John Hausenloy, Joseph Addison Hill, Linda Wilhelmina Van Laake, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Manuel Mayr, Fabrice Prunier, Joost Petrus Geradus Sluijter, Rainer Schulz, Thomas Thum, Kirsti Ytrehus, Péter Ferdinandy Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart published pages: 725-736, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx070 |
Cardiovascular Research 113/7 | 2019-06-06 |
| 2016 |
Christian Bär, Shambhabi Chatterjee, Thomas Thum Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy published pages: 1484-1499, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.023686 |
Circulation 134/19 | 2019-06-06 |
| 2017 |
A. Bührke, C. Bär, T. Thum Nichtkodierende RNA published pages: , ISSN: 0340-9937, DOI: 10.1007/s00059-017-4660-4 |
Herz | 2019-06-06 |
| 2018 |
Shashi Kumar Gupta, Ankita Garg, Christian Bär, Shambhabi Chatterjee, Ariana Foinquinos, Hendrik Milting, Katrin Streckfuß-Bömeke, Jan Fiedler, Thomas Thum Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA ExpressionNovelty and Significance published pages: 246-254, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.311335 |
Circulation Research 122/2 | 2019-06-06 |
| 2016 |
Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A. Boon, Leon J. de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction published pages: 1557-1571, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.07.739 |
Journal of the American College of Cardiology 68/14 | 2019-06-06 |
| 2017 |
Janika Viereck, Thomas Thum Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury published pages: 381-399, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.308434 |
Circulation Research 120/2 | 2019-06-06 |
| 2016 |
Maria-Teresa Piccoli, Christian Bär, Thomas Thum Non-coding RNAs as modulators of the cardiac fibroblast phenotype published pages: 75-81, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2015.12.023 |
Journal of Molecular and Cellular Cardiology 92 | 2019-06-06 |
| 2016 |
J. Viereck, R. Kumarswamy, A. Foinquinos, K. Xiao, P. Avramopoulos, M. Kunz, M. Dittrich, T. Maetzig, K. Zimmer, J. Remke, A. Just, J. Fendrich, K. Scherf, E. Bolesani, A. Schambach, F. Weidemann, R. Zweigerdt, L. J. de Windt, S. Engelhardt, T. Dandekar, S. Batkai, T. Thum Long noncoding RNA Chast promotes cardiac remodeling published pages: 326ra22-326ra22, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aaf1475 |
Science Translational Medicine 8/326 | 2019-06-06 |
| 2017 |
Yvan Devaux, Esther E. Creemers, Reinier A. Boon, Stanislas Werfel, Thomas Thum, Stefan Engelhardt, Stefanie Dimmeler, Iain Squire Circular RNAs in heart failure published pages: 701-709, ISSN: 1388-9842, DOI: 10.1002/ejhf.801 |
European Journal of Heart Failure 19/6 | 2019-06-06 |
| 2016 |
David de Gonzalo-Calvo, Franziska Kenneweg, Claudia Bang, RocÃo Toro, Rutger W. van der Meer, Luuk J. Rijzewijk, Johannes W.A. Smit, Hildo J. Lamb, Vicenta Llorente-Cortes, Thomas Thum Circulating Long Noncoding RNAs in Personalized Medicine published pages: 2914-2916, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.10.014 |
Journal of the American College of Cardiology 68/25 | 2019-06-06 |
| 2017 |
Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix Kleemiß, Regalla Kumarswamy, Katharina Schimmel, Christian Bär, Thomas Thum A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation published pages: 307-318, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.158 |
Cell Death and Differentiation 25/2 | 2019-06-06 |
| 2017 |
Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01737-4 |
Nature Communications 8/1 | 2019-06-06 |
| 2016 |
Jan-Marcus Daniel, André Prock, Jochen Dutzmann, Kristina Sonnenschein, Thomas Thum, Johann Bauersachs, Daniel G. Sedding Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima FormationSignificance published pages: 317-327, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.115.305974 |
Arteriosclerosis, Thrombosis, and Vascular Biology 36/2 | 2019-06-06 |
| 2015 |
Thomas Thum Antiageing concepts and cardiovascular disease published pages: 3435-3436, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehv412 |
European Heart Journal 36/48 | 2019-06-06 |
| 2017 |
Shambhabi Chatterjee, Christian Bär, Thomas Thum Linc- ing the Noncoding Genome to Heart Function: Beating Hypertrophy published pages: 577-579, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2017.05.007 |
Trends in Molecular Medicine 23/7 | 2019-06-06 |
| 2016 |
D. de Gonzalo-Calvo, F. Kenneweg, C. Bang, R. Toro, R. W. van der Meer, L. J. Rijzewijk, J. W. Smit, H. J. Lamb, V. Llorente-Cortes, T. Thum Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes published pages: 37354, ISSN: 2045-2322, DOI: 10.1038/srep37354 |
Scientific Reports 6 | 2019-06-06 |
| 2016 |
Shashi Kumar Gupta, Thomas Thum Non-coding RNAs as orchestrators of autophagic processes published pages: 26-30, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2015.11.012 |
Journal of Molecular and Cellular Cardiology 95 | 2019-06-06 |
| 2016 |
Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N. Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M. Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya Otsu, Manuel Mayr Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial FibrillationClinical Perspective published pages: 817-832, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.115.016423 |
Circulation 134/11 | 2019-06-06 |
| 2017 |
Christian Bär, Thomas Thum A long way for microRNAs to become meaningful prognostic biomarkers published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1036 |
European Journal of Heart Failure | 2019-06-06 |
| 2016 |
Julia Beermann, Maria-Teresa Piccoli, Janika Viereck, Thomas Thum Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches published pages: 1297-1325, ISSN: 0031-9333, DOI: 10.1152/physrev.00041.2015 |
Physiological Reviews 96/4 | 2019-06-06 |
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