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LONGHEART SIGNED

Exploring selected long non-coding RNAs as diagnostics and therapeutic targets for heart failure

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EC-Contrib. €

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Project "LONGHEART" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE HOCHSCHULE HANNOVER 

Organization address
address: Carl-Neuberg-Strasse 1
city: HANNOVER
postcode: 30625
website: www.mh-hannover.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙816˙250 €
 EC max contribution 1˙816˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE HOCHSCHULE HANNOVER DE (HANNOVER) coordinator 1˙816˙250.00

Map

 Project objective

Despite clinical advances, diseases of the cardiovascular system are the most common cause of morbidity and mortality in the EU with currently 50 million people suffering from heart failure. These important challenges call for a better understanding of underlying mechanisms to enable development of innovative, effective diagnostic and therapeutic strategies for heart failure. Cardiac stress such as myocardial infarction or hypertension leads to cellular “remodeling” of the left ventricle resulting in heart failure. Protein-coding genes originate from only 1.5% of the genome, whereas the larger remaining portion is often transcribed to non-coding RNAs, of which functional importance is still ill understood. We pioneered a role of small microRNAs as diagnostics and therapeutic targets for heart failure (Nature, 2008; Nature Comm, 2012, J Clin Invest, 2014). We now will focus on the larger fraction of long non-coding RNAs (lncRNAs) and their functional roles, as well as diagnostic and therapeutic use in heart failure. The proposal has the following interconnected objectives: a) identify novel functional relevant cardiac remodeling-associated lncRNAs; b) characterise key lncRNA cardiac targetomes; c) investigate lncRNA-paracrine mechanisms and the diagnostic and prognostic potential of cardiac-derived extracellular lncRNAs using large clinical cohorts; and d) discover their therapeutic potential to prevent cardiac remodeling in clinically relevant animal models. Innovative molecular and cell-based methods, a unique lncRNA-shRNA library, genetic animal models and availability of large clinical biobanks will form the basis for a successful strategy. LONGHEART will lead to ground-breaking new insight into the role of lncRNAs in the heart. These findings will firmly establish lncRNA-based mechanisms to identify fundamentally novel diagnostic and therapeutic entry points for a most serious clinical important disorder in dire need for new diagnostic and therapeutic paradigms.

 Publications

year authors and title journal last update
List of publications.
2017 Christian Bär, Thomas Thum
Changing Direction
published pages: 1393-1395, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.310316
Circulation Research 120/9 2019-06-06
2015 Sandra C. Mayer, Ralf Gilsbach, Sebastian Preissl, Elsa Beatriz Monroy Ordonez, Tilman Schnick, Nadine Beetz, Achim Lother, Carolin Rommel, Hannah Ihle, Heiko Bugger, Frank Rühle, Andrea Schrepper, Michael Schwarzer, Claudia Heilmann, Ulrike Bönisch, Shashi Kumar Gupta, Jochen Wilpert, Oliver Kretz, Dominik von Elverfeldt, Joachim Orth, Klaus Aktories, Friedhelm Beyersdorf, Christoph Bode, Brigitte Stiller, Markus Krüger, Thomas Thum, Torsten Doenst, Monika Stoll, Lutz Hein
Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart FailureNovelty and Significance
published pages: 622-633, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.115.306721
Circulation Research 117/7 2019-06-06
2017 Maria-Teresa Piccoli, Shashi Kumar Gupta, Janika Viereck, Ariana Foinquinos, Sabine Samolovac, Freya Luise Kramer, Ankita Garg, Janet Remke, Karina Zimmer, Sandor Batkai, Thomas Thum
Inhibition of the Cardiac Fibroblast–Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic DysfunctionNovelty and Significance
published pages: 575-583, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.310624
Circulation Research 121/5 2019-06-06
2017 Janika Viereck, Thomas Thum
Long Noncoding RNAs in Pathological Cardiac Remodeling
published pages: 262-264, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.310174
Circulation Research 120/2 2019-06-06
2017 Serge Masson, Sandor Batkai, Julia Beermann, Christian Bär, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum
Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure
published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.961
European Journal of Heart Failure 2019-06-06
2017 Ke Xiao, Thomas Thum
Exosomal MicroRNAs Released by Pediatric Cardiac Progenitor Cells
published pages: 607-609, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.310443
Circulation Research 120/4 2019-06-06
2017 Cinzia Perrino, Albert-Laszló Barabási, Gianluigi Condorelli, Sean Michael Davidson, Leon De Windt, Stefanie Dimmeler, Felix Benedikt Engel, Derek John Hausenloy, Joseph Addison Hill, Linda Wilhelmina Van Laake, Sandrine Lecour, Jonathan Leor, Rosalinda Madonna, Manuel Mayr, Fabrice Prunier, Joost Petrus Geradus Sluijter, Rainer Schulz, Thomas Thum, Kirsti Ytrehus, Péter Ferdinandy
Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart
published pages: 725-736, ISSN: 0008-6363, DOI: 10.1093/cvr/cvx070
Cardiovascular Research 113/7 2019-06-06
2016 Christian Bär, Shambhabi Chatterjee, Thomas Thum
Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy
published pages: 1484-1499, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.116.023686
Circulation 134/19 2019-06-06
2017 A. Bührke, C. Bär, T. Thum
Nichtkodierende RNA
published pages: , ISSN: 0340-9937, DOI: 10.1007/s00059-017-4660-4
Herz 2019-06-06
2018 Shashi Kumar Gupta, Ankita Garg, Christian Bär, Shambhabi Chatterjee, Ariana Foinquinos, Hendrik Milting, Katrin Streckfuß-Bömeke, Jan Fiedler, Thomas Thum
Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA ExpressionNovelty and Significance
published pages: 246-254, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.117.311335
Circulation Research 122/2 2019-06-06
2016 Shashi Kumar Gupta, Ariana Foinquinos, Sabrina Thum, Janet Remke, Karina Zimmer, Christophe Bauters, Pascal de Groote, Reinier A. Boon, Leon J. de Windt, Sebastian Preissl, Lutz Hein, Sandor Batkai, Florence Pinet, Thomas Thum
Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction
published pages: 1557-1571, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.07.739
Journal of the American College of Cardiology 68/14 2019-06-06
2017 Janika Viereck, Thomas Thum
Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury
published pages: 381-399, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.308434
Circulation Research 120/2 2019-06-06
2016 Maria-Teresa Piccoli, Christian Bär, Thomas Thum
Non-coding RNAs as modulators of the cardiac fibroblast phenotype
published pages: 75-81, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2015.12.023
Journal of Molecular and Cellular Cardiology 92 2019-06-06
2016 J. Viereck, R. Kumarswamy, A. Foinquinos, K. Xiao, P. Avramopoulos, M. Kunz, M. Dittrich, T. Maetzig, K. Zimmer, J. Remke, A. Just, J. Fendrich, K. Scherf, E. Bolesani, A. Schambach, F. Weidemann, R. Zweigerdt, L. J. de Windt, S. Engelhardt, T. Dandekar, S. Batkai, T. Thum
Long noncoding RNA Chast promotes cardiac remodeling
published pages: 326ra22-326ra22, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aaf1475
Science Translational Medicine 8/326 2019-06-06
2017 Yvan Devaux, Esther E. Creemers, Reinier A. Boon, Stanislas Werfel, Thomas Thum, Stefan Engelhardt, Stefanie Dimmeler, Iain Squire
Circular RNAs in heart failure
published pages: 701-709, ISSN: 1388-9842, DOI: 10.1002/ejhf.801
European Journal of Heart Failure 19/6 2019-06-06
2016 David de Gonzalo-Calvo, Franziska Kenneweg, Claudia Bang, Rocío Toro, Rutger W. van der Meer, Luuk J. Rijzewijk, Johannes W.A. Smit, Hildo J. Lamb, Vicenta Llorente-Cortes, Thomas Thum
Circulating Long Noncoding RNAs in Personalized Medicine
published pages: 2914-2916, ISSN: 0735-1097, DOI: 10.1016/j.jacc.2016.10.014
Journal of the American College of Cardiology 68/25 2019-06-06
2017 Julia Beermann, Dominique Kirste, Katharina Iwanov, Dongchao Lu, Felix Kleemiß, Regalla Kumarswamy, Katharina Schimmel, Christian Bär, Thomas Thum
A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation
published pages: 307-318, ISSN: 1350-9047, DOI: 10.1038/cdd.2017.158
Cell Death and Differentiation 25/2 2019-06-06
2017 Yassine Sassi, Petros Avramopoulos, Deepak Ramanujam, Laurenz Grüter, Stanislas Werfel, Simon Giosele, Andreas-David Brunner, Dena Esfandyari, Aikaterini S. Papadopoulou, Bart De Strooper, Norbert Hübner, Regalla Kumarswamy, Thomas Thum, Xiaoke Yin, Manuel Mayr, Bernhard Laggerbauer, Stefan Engelhardt
Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01737-4
Nature Communications 8/1 2019-06-06
2016 Jan-Marcus Daniel, André Prock, Jochen Dutzmann, Kristina Sonnenschein, Thomas Thum, Johann Bauersachs, Daniel G. Sedding
Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima FormationSignificance
published pages: 317-327, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.115.305974
Arteriosclerosis, Thrombosis, and Vascular Biology 36/2 2019-06-06
2015 Thomas Thum
Antiageing concepts and cardiovascular disease
published pages: 3435-3436, ISSN: 0195-668X, DOI: 10.1093/eurheartj/ehv412
European Heart Journal 36/48 2019-06-06
2017 Shambhabi Chatterjee, Christian Bär, Thomas Thum
Linc- ing the Noncoding Genome to Heart Function: Beating Hypertrophy
published pages: 577-579, ISSN: 1471-4914, DOI: 10.1016/j.molmed.2017.05.007
Trends in Molecular Medicine 23/7 2019-06-06
2016 D. de Gonzalo-Calvo, F. Kenneweg, C. Bang, R. Toro, R. W. van der Meer, L. J. Rijzewijk, J. W. Smit, H. J. Lamb, V. Llorente-Cortes, T. Thum
Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes
published pages: 37354, ISSN: 2045-2322, DOI: 10.1038/srep37354
Scientific Reports 6 2019-06-06
2016 Shashi Kumar Gupta, Thomas Thum
Non-coding RNAs as orchestrators of autophagic processes
published pages: 26-30, ISSN: 0022-2828, DOI: 10.1016/j.yjmcc.2015.11.012
Journal of Molecular and Cellular Cardiology 95 2019-06-06
2016 Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N. Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M. Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya Otsu, Manuel Mayr
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial FibrillationClinical Perspective
published pages: 817-832, ISSN: 0009-7322, DOI: 10.1161/CIRCULATIONAHA.115.016423
Circulation 134/11 2019-06-06
2017 Christian Bär, Thomas Thum
A long way for microRNAs to become meaningful prognostic biomarkers
published pages: , ISSN: 1388-9842, DOI: 10.1002/ejhf.1036
European Journal of Heart Failure 2019-06-06
2016 Julia Beermann, Maria-Teresa Piccoli, Janika Viereck, Thomas Thum
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
published pages: 1297-1325, ISSN: 0031-9333, DOI: 10.1152/physrev.00041.2015
Physiological Reviews 96/4 2019-06-06

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