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PAERADOX SIGNED

Precursors to Modern Aerobic Ammonium Oxidation: Oxygenic and Electrogenic Anaerobic Pathways

Total Cost €

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EC-Contrib. €

0

Partnership

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 PAERADOX project word cloud

Explore the words cloud of the PAERADOX project. It provides you a very rough idea of what is the project "PAERADOX" about.

how    discovering    eet    followed    biology    nh4    contribution    molecular    enzyme    hence    nitrifiers    history    am    scientific    planets    tagged    investment    microbes    return    metabolisms    area    basis    anps    life    phylogenetic    dismutase    me    anaerobic    notion    signals    nitrospira    chlorite    methylomirabilis    contend    evolve    fluorescent    modern    combination    interdisciplinary    intracellular    confident    skills    conditions    did    evolution    single    seek    aps    computational    microbial    oxidation    sorted    ancient    unravelling    mit    clues    bes    electrochemical    strength    dtu    anoxic    remnants    fac    cell    reintegration    mediated    aerobic    respiration    experiments    vestiges    ecology    o2    aerobiosis    essentially    persist    strict    dependent    evolutionary    international    genomics    central    paeradox    platform    mystery    earth    postulate    training    derive    isotopic    physiology    mobility    career    community    aerobes    integral    unresolved    few    origins    constructed    transfer    network    genomic    batch    excellent    harvard    cells    incubations    contain    earliest   

Project "PAERADOX" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 278˙227 €
 EC max contribution 278˙227 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 278˙227.00
2    PRESIDENT AND FELLOWS OF HARVARD COLLEGE US (CAMBRIDGE) partner 0.00

Map

 Project objective

How did microbes evolve to use O2? How did O2-dependent pathways derive from or evolve under anoxic conditions? This central evolutionary mystery remains essentially unresolved. I contend that it is possible to identify the evolutionary history of modern aerobic pathways (APs), by discovering the vestiges of ancient anaerobic pathways (AnPs) that persist in modern microbes. Aerobic nitrifiers contain aerobic metabolisms, while few clues such as chlorite dismutase enzyme in Nitrospira, NO dismutase enzyme in Methylomirabilis, and electrochemical signals from aerobic nitrifiers support the notion that remnants of AnPs remain. Hence, I postulate that in nitrifiers currently considered strict aerobes, I can identify the vestiges and integral remains of the earliest APs: I will identify the AnPs of NH4 oxidation that are driven by intracellular O2 production and respiration mediated by EET. By applying BES and batch incubations followed by isotopic and genomic experiments will evidence and characterize the novel AnPs in nitrifiers. Single cell genomics on FAC-sorted fluorescent-tagged cells followed by molecular phylogenetic analysis will provide a major contribution to unravelling the early evolution of aerobiosis and aerobic NH4 oxidation, which is crucial as we seek the origins of life on Earth, and other planets. PAERADOX will provide me an interdisciplinary research training in the area of microbial physiology and genomics, molecular biology and computational evolution through international mobility (Harvard, MIT and DTU). Such a training-through-research platform will enhance my career development to a large extent. My return and reintegration to DTU will provide basis to transfer my interdisciplinary combination to European scientific community. I am confident that the international network, skills and knowledge that will be constructed during PAERADOX is an excellent investment for my future and for EU’s strength in the field of microbial evolution and ecology.

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The information about "PAERADOX" are provided by the European Opendata Portal: CORDIS opendata.

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