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NOVCARBFIX SIGNED

Analysis, Design and Experimental Evolution of Novel Carbon Fixation Pathways

Total Cost €

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EC-Contrib. €

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Partnership

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 NOVCARBFIX project word cloud

Explore the words cloud of the NOVCARBFIX project. It provides you a very rough idea of what is the project "NOVCARBFIX" about.

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Project "NOVCARBFIX" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙999˙843 €
 EC max contribution 1˙999˙843 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙999˙843.00

Map

 Project objective

Carbon fixation is a prerequisite for accumulating biomass and storing energy in most of the living world. As such, it supplies our food and dominates land and water usage by humanity. In agriculture, where water and nutrients are abundant, the rate of carbon fixation often limits growth rate. Therefore increasing the rate of carbon fixation is of global importance towards agricultural and energetic sustainability. What are the limits on the possible rate of carbon fixation? Attempts to improve RuBisCO, the key enzyme in the Calvin-Benson cycle, have achieved only limited results. My lab focuses on trying to overcome this global challenge by building synthetic pathways for carbon fixation. We create a computational framework that designs and scores pathways and creates step-wise selection strategies for in-vivo experimental implementation. Our most promising synthetic carbon fixation pathways are found to utilize the highly effective carboxylating enzyme, PEP carboxylase. We experimentally test these pathways in the most genetically tractable context by constructing an E.coli strain that depends on atmospheric CO2 fixation. We will gradually incorporate the pathways, initially as essential reaction steps for biomass production, and finally with CO2 as sole carbon input of the cell. As a stepping-stone towards this challenging goal, we will construct an autotrophic E.coli strain that uses the Calvin-Benson cycle. We systematically convert this synthetic biology grand challenge into a gradual evolutionary ladder with independently selectable steps. We recently achieved key steps in the ladder, such as semi-autotrophic growth, serving as powerful proofs of concept. The proposed research will advance our basic-science understanding of evolutionary plasticity of metabolic pathways. It also paves the way for a hybrid rational-design/experimental-evolution approach to revisit and advance the capacity of metabolism for agricultural productivity and renewable energy storage.

 Publications

year authors and title journal last update
List of publications.
2018 Alon Shepon, Gidon Eshel, Elad Noor, Ron Milo
The opportunity cost of animal based diets exceeds all food losses
published pages: 3804-3809, ISSN: 0027-8424, DOI: 10.1073/pnas.1713820115
Proceedings of the National Academy of Sciences 115/15 2019-10-08
2017 Elad Herz, Niv Antonovsky, Yinon Bar-On, Dan Davidi, Shmuel Gleizer, Noam Prywes, Lianet Noda-Garcia, Keren Lyn Frisch, Yehudit Zohar, David G. Wernick, Alon Savidor, Uri Barenholz, Ron Milo
The genetic basis for the adaptation of E. coli to sugar synthesis from CO2
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01835-3
Nature Communications 8/1 2019-06-05
2017 Uri Barenholz, Dan Davidi, Ed Reznik, Yinon Bar-On, Niv Antonovsky, Elad Noor, Ron Milo
Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.20667
eLife 6 2019-06-05
2016 Uri Barenholz, Leeat Keren, Eran Segal, Ron Milo
A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate
published pages: e0153344, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0153344
PLOS ONE 11/4 2019-06-05
2016 Ron Sender, Shai Fuchs, Ron Milo
Revised Estimates for the Number of Human and Bacteria Cells in the Body
published pages: e1002533, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.1002533
PLOS Biology 14/8 2019-06-05
2016 Niv Antonovsky, Shmuel Gleizer, Elad Noor, Yehudit Zohar, Elad Herz, Uri Barenholz, Lior Zelcbuch, Shira Amram, Aryeh Wides, Naama Tepper, Dan Davidi, Yinon Bar-On, Tasneem Bareia, David G. Wernick, Ido Shani, Sergey Malitsky, Ghil Jona, Arren Bar-Even, Ron Milo
Sugar Synthesis from CO2 in Escherichia coli
published pages: 115-125, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.05.064
Cell 166/1 2019-06-05

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