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Profile Infection SIGNED

Unraveling changes in cellular gene expression during viral infection

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EC-Contrib. €

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Partnership

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Project "Profile Infection" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙500˙000.00

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 Project objective

The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great interest as they have the potential to provide new therapeutic windows and reveal novel principles in cell biology. Over the past years high-throughput analyses have profoundly broadened our understanding of the processes that occur during HCMV infection. However, much of this analysis is focused on transcriptional changes at the lytic phase of infection leaving posttranscriptional regulation and the latent phase of the virus relatively untouched. Novel emerging technologies have the potential to extend our knowledge in areas that were heretofore unattainable. My overall goal is to decipher the multiple mechanisms by which HCMV modulates the host cell. For this, I will use multiple cutting-edge deep-sequencing and imaging technologies that will allow the analysis of novel aspects of host gene regulation during infection. Accordingly, the primary objectives of this research proposal are: 1) Deciphering posttranscriptional mechanisms that control cellular gene expression during HCMV infection; 2) Identifying and characterizing cellular protein diversification during infection; and 3) Uncovering the changes that occur in infected cells during latent infection. The knowledge generated from these objectives will provide us with a clearer depiction of the changes that take place during HCMV infection, which in turn can facilitate the development of novel anti-viral strategies. More broadly, with its comprehensive and complementarity approaches, this work will provide a paradigm for understanding how gene expression is regulated during a complex biological process.

 Publications

year authors and title journal last update
List of publications.
2019 Roni Winkler, Ella Gillis, Lior Lasman, Modi Safra, Shay Geula, Clara Soyris, Aharon Nachshon, Julie Tai-Schmiedel, Nehemya Friedman, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Michal Mandelboim, Jacob H. Hanna, Schraga Schwartz, Noam Stern-Ginossar
m6A modification controls the innate immune response to infection by targeting type I interferons
published pages: 173-182, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0275-z
Nature Immunology 20/2 2020-02-04
2018 Orel Mizrahi, Aharon Nachshon, Alina Shitrit, Idit A. Gelbart, Martina Dobesova, Shirly Brenner, Chaim Kahana, Noam Stern-Ginossar
Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression
published pages: 862-874.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.09.003
Molecular Cell 72/5 2020-02-04
2019 Erez Eliyahu, Osnat Tirosh, Martina Dobesova, Aharon Nachshon, Michal Schwartz, Noam Stern-Ginossar
Rho-Associated Coiled-Coil Kinase 1 Translocates to the Nucleus and Inhibits Human Cytomegalovirus Propagation
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.00453-19
Journal of Virology 93/19 2020-02-04
2020 Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.52168
eLife 9 2020-02-04
2018 Miri Shnayder, Aharon Nachshon, Benjamin Krishna, Emma Poole, Alina Boshkov, Amit Binyamin, Itay Maza, John Sinclair, Michal Schwartz, Noam Stern-Ginossar
Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing
published pages: e00013-18, ISSN: 2150-7511, DOI: 10.1128/mBio.00013-18
mBio 9/2 2019-06-05
2016 Adi Bercovich-Kinori, Julie Tai, Idit Anna Gelbart, Alina Shitrit, Shani Ben-Moshe, Yaron Drori, Shalev Itzkovitz, Michal Mandelboim, Noam Stern-Ginossar
A systematic view on influenza induced host shutoff
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.18311
eLife 5 2019-06-05

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