Explore the words cloud of the Profile Infection project. It provides you a very rough idea of what is the project "Profile Infection" about.
The following table provides information about the project.
WEIZMANN INSTITUTE OF SCIENCE
|Coordinator Country||Israel [IL]|
|Total cost||1˙500˙000 €|
|EC max contribution||1˙500˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2020-05-31|
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|1||WEIZMANN INSTITUTE OF SCIENCE||IL (REHOVOT)||coordinator||1˙500˙000.00|
The herpesvirus human cytomegalovirus (HCMV) infects the majority of the world's population, leading to severe diseases in millions of newborns and immunocompromised adults annually. During infection, HCMV extensively manipulates cellular gene expression to maintain conditions favorable for efficient viral propagation. Identifying the pathways that the virus relies on or subverts is of great interest as they have the potential to provide new therapeutic windows and reveal novel principles in cell biology. Over the past years high-throughput analyses have profoundly broadened our understanding of the processes that occur during HCMV infection. However, much of this analysis is focused on transcriptional changes at the lytic phase of infection leaving posttranscriptional regulation and the latent phase of the virus relatively untouched. Novel emerging technologies have the potential to extend our knowledge in areas that were heretofore unattainable. My overall goal is to decipher the multiple mechanisms by which HCMV modulates the host cell. For this, I will use multiple cutting-edge deep-sequencing and imaging technologies that will allow the analysis of novel aspects of host gene regulation during infection. Accordingly, the primary objectives of this research proposal are: 1) Deciphering posttranscriptional mechanisms that control cellular gene expression during HCMV infection; 2) Identifying and characterizing cellular protein diversification during infection; and 3) Uncovering the changes that occur in infected cells during latent infection. The knowledge generated from these objectives will provide us with a clearer depiction of the changes that take place during HCMV infection, which in turn can facilitate the development of novel anti-viral strategies. More broadly, with its comprehensive and complementarity approaches, this work will provide a paradigm for understanding how gene expression is regulated during a complex biological process.
|year||authors and title||journal||last update|
Roni Winkler, Ella Gillis, Lior Lasman, Modi Safra, Shay Geula, Clara Soyris, Aharon Nachshon, Julie Tai-Schmiedel, Nehemya Friedman, Vu Thuy Khanh Le-Trilling, Mirko Trilling, Michal Mandelboim, Jacob H. Hanna, Schraga Schwartz, Noam Stern-Ginossar
m6A modification controls the innate immune response to infection by targeting type I interferons
published pages: 173-182, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0275-z
|Nature Immunology 20/2||2020-02-04|
Orel Mizrahi, Aharon Nachshon, Alina Shitrit, Idit A. Gelbart, Martina Dobesova, Shirly Brenner, Chaim Kahana, Noam Stern-Ginossar
Virus-Induced Changes in mRNA Secondary Structure Uncover cis-Regulatory Elements that Directly Control Gene Expression
published pages: 862-874.e5, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.09.003
|Molecular Cell 72/5||2020-02-04|
Erez Eliyahu, Osnat Tirosh, Martina Dobesova, Aharon Nachshon, Michal Schwartz, Noam Stern-Ginossar
Rho-Associated Coiled-Coil Kinase 1 Translocates to the Nucleus and Inhibits Human Cytomegalovirus Propagation
published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.00453-19
|Journal of Virology 93/19||2020-02-04|
Miri Shnayder, Aharon Nachshon, Batsheva Rozman, Biana Bernshtein, Michael Lavi, Noam Fein, Emma Poole, Selmir Avdic, Emily Blyth, David Gottlieb, Allison Abendroth, Barry Slobedman, John Sinclair, Noam Stern-Ginossar, Michal Schwartz
Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.52168
Miri Shnayder, Aharon Nachshon, Benjamin Krishna, Emma Poole, Alina Boshkov, Amit Binyamin, Itay Maza, John Sinclair, Michal Schwartz, Noam Stern-Ginossar
Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing
published pages: e00013-18, ISSN: 2150-7511, DOI: 10.1128/mBio.00013-18
Adi Bercovich-Kinori, Julie Tai, Idit Anna Gelbart, Alina Shitrit, Shani Ben-Moshe, Yaron Drori, Shalev Itzkovitz, Michal Mandelboim, Noam Stern-Ginossar
A systematic view on influenza induced host shutoff
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.18311
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