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REGiREG SIGNED

Regulating the immune regulators: targeting adaptive immune control

Total Cost €

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EC-Contrib. €

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Partnership

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Project "REGiREG" data sheet

The following table provides information about the project.

Coordinator
KLINIKUM DER UNIVERSITAET REGENSBURG 

Organization address
address: FRANS JOSEF STRAUSS ALLEE 11
city: REGENSBURG
postcode: 93053
website: www-cgi.uni-regensburg.de/Klinik/Klinikum/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙955˙000 €
 EC max contribution 1˙955˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KLINIKUM DER UNIVERSITAET REGENSBURG DE (REGENSBURG) coordinator 1˙522˙376.00
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) participant 432˙623.00

Map

 Project objective

The immune system with its complex interactions of cells and molecules needs a very tight and specific interplay of control elements to ensure the establishment and re-establishment of immune homeostasis after challenges. Regulatory T cells (Tregs) are key-players in this regulatory network. It is now well accepted that deficiency or dysfunction of Tregs causes various severe immune disorders due to immune hyperactivation. Conversely, an increased number of Tregs in tumor-bearing individuals suppresses efficient anti-tumor immunity and, thereby, is often associated with poor prognosis. Cancer immunology is now one of the most exciting and promising frontiers in cancer research, and recent clinical trials have proven that immunotherapies driving to activate T cells can induce durable responses. In this sense, harnessing the potential of Tregs is one of the most promising new approaches to control immune function and to treat cancer. This proposal has two objectives: 1, the identification and characterization of tissue-resident Tregs to principally understand the unique features of Treg specialization in tissues and their function in organ-homeostasis, a phenomenon that is hardly understood, but holds great promise for local, tissue-specific immune intervention. 2, to globally target Tregs, including the lymphoid organ Treg pool, by interfering with their survival and or suppression function. We expect from these studies new basic insights into a fascinating and still arcane aspect of organ-homeostasis as maintained by Tregs, as well as novel small molecule inhibitors and candidate molecules that target Tregs at the systemic level, and eventually at a tissue-specific level.

 Publications

year authors and title journal last update
List of publications.
2020 Michael Delacher, Charles D. Imbusch, Agnes Hotz-Wagenblatt, Jan-Philipp Mallm, Katharina Bauer, Malte Simon, Dania Riegel, André F. Rendeiro, Sebastian Bittner, Lieke Sanderink, Asmita Pant, Lisa Schmidleithner, Kathrin L. Braband, Bernd Echtenachter, Alexander Fischer, Valentina Giunchiglia, Petra Hoffmann, Matthias Edinger, Christoph Bock, Michael Rehli, Benedikt Brors, Christian Schmidl, Mark
Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF
published pages: , ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.12.002
Immunity 2020-03-17
2019 Michael Delacher, Christian Schmidl, Yonatan Herzig, Minka Breloer, Wiebke Hartmann, Fabian Brunk, Danny Kägebein, Ulrike Träger, Ann-Cathrin Hofer, Sebastian Bittner, Dieter Weichenhan, Charles D. Imbusch, Agnes Hotz-Wagenblatt, Thomas Hielscher, Achim Breiling, Giuseppina Federico, Hermann-Josef Gröne, Roland M. Schmid, Michael Rehli, Jakub Abramson, Markus Feuerer
Rbpj expression in regulatory T cells is critical for restraining TH2 responses
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09276-w
Nature Communications 10/1 2020-03-17
2018 Christian Schmidl, Michael Delacher, Jochen Huehn, Markus Feuerer
Epigenetic mechanisms regulating T-cell responses
published pages: 728-743, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.07.014
Journal of Allergy and Clinical Immunology 142/3 2020-03-17
2016 David M. Richards, Bruno Kyewski, Markus Feuerer
Re-examining the Nature and Function of Self-Reactive T cells
published pages: 114-125, ISSN: 1471-4906, DOI: 10.1016/j.it.2015.12.005
Trends in Immunology 37/2 2020-03-17
2017 Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt, Ulrike Träger, Ann-Cathrin Hofer, Danny Kägebein, Qi Wang, Felix Frauhammer, Jan-Philipp Mallm, Katharina Bauer, Carl Herrmann, Philipp A Lang, Benedikt Brors, Christoph Plass, Markus Feuerer
Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues
published pages: 1160-1172, ISSN: 1529-2908, DOI: 10.1038/ni.3799
Nature Immunology 18/10 2020-03-17

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