Explore the words cloud of the REGiREG project. It provides you a very rough idea of what is the project "REGiREG" about.
The following table provides information about the project.
KLINIKUM DER UNIVERSITAET REGENSBURG
|Coordinator Country||Germany [DE]|
|Total cost||1˙955˙000 €|
|EC max contribution||1˙955˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2021-06-30|
Take a look of project's partnership.
|1||KLINIKUM DER UNIVERSITAET REGENSBURG||DE (REGENSBURG)||coordinator||1˙522˙376.00|
|2||DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG||DE (HEIDELBERG)||participant||432˙623.00|
The immune system with its complex interactions of cells and molecules needs a very tight and specific interplay of control elements to ensure the establishment and re-establishment of immune homeostasis after challenges. Regulatory T cells (Tregs) are key-players in this regulatory network. It is now well accepted that deficiency or dysfunction of Tregs causes various severe immune disorders due to immune hyperactivation. Conversely, an increased number of Tregs in tumor-bearing individuals suppresses efficient anti-tumor immunity and, thereby, is often associated with poor prognosis. Cancer immunology is now one of the most exciting and promising frontiers in cancer research, and recent clinical trials have proven that immunotherapies driving to activate T cells can induce durable responses. In this sense, harnessing the potential of Tregs is one of the most promising new approaches to control immune function and to treat cancer. This proposal has two objectives: 1, the identification and characterization of tissue-resident Tregs to principally understand the unique features of Treg specialization in tissues and their function in organ-homeostasis, a phenomenon that is hardly understood, but holds great promise for local, tissue-specific immune intervention. 2, to globally target Tregs, including the lymphoid organ Treg pool, by interfering with their survival and or suppression function. We expect from these studies new basic insights into a fascinating and still arcane aspect of organ-homeostasis as maintained by Tregs, as well as novel small molecule inhibitors and candidate molecules that target Tregs at the systemic level, and eventually at a tissue-specific level.
|year||authors and title||journal||last update|
Michael Delacher, Charles D. Imbusch, Agnes Hotz-Wagenblatt, Jan-Philipp Mallm, Katharina Bauer, Malte Simon, Dania Riegel, AndrÃ© F. Rendeiro, Sebastian Bittner, Lieke Sanderink, Asmita Pant, Lisa Schmidleithner, Kathrin L. Braband, Bernd Echtenachter, Alexander Fischer, Valentina Giunchiglia, Petra Hoffmann, Matthias Edinger, Christoph Bock, Michael Rehli, Benedikt Brors, Christian Schmidl, Mark
Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF
published pages: , ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.12.002
Michael Delacher, Christian Schmidl, Yonatan Herzig, Minka Breloer, Wiebke Hartmann, Fabian Brunk, Danny KÃ¤gebein, Ulrike TrÃ¤ger, Ann-Cathrin Hofer, Sebastian Bittner, Dieter Weichenhan, Charles D. Imbusch, Agnes Hotz-Wagenblatt, Thomas Hielscher, Achim Breiling, Giuseppina Federico, Hermann-Josef GrÃ¶ne, Roland M. Schmid, Michael Rehli, Jakub Abramson, Markus Feuerer
Rbpj expression in regulatory T cells is critical for restraining TH2 responses
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09276-w
|Nature Communications 10/1||2020-03-17|
Christian Schmidl, Michael Delacher, Jochen Huehn, Markus Feuerer
Epigenetic mechanisms regulating T-cell responses
published pages: 728-743, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.07.014
|Journal of Allergy and Clinical Immunology 142/3||2020-03-17|
David M. Richards, Bruno Kyewski, Markus Feuerer
Re-examining the Nature and Function of Self-Reactive T cells
published pages: 114-125, ISSN: 1471-4906, DOI: 10.1016/j.it.2015.12.005
|Trends in Immunology 37/2||2020-03-17|
Michael Delacher, Charles D Imbusch, Dieter Weichenhan, Achim Breiling, Agnes Hotz-Wagenblatt, Ulrike TrÃ¤ger, Ann-Cathrin Hofer, Danny KÃ¤gebein, Qi Wang, Felix Frauhammer, Jan-Philipp Mallm, Katharina Bauer, Carl Herrmann, Philipp A Lang, Benedikt Brors, Christoph Plass, Markus Feuerer
Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues
published pages: 1160-1172, ISSN: 1529-2908, DOI: 10.1038/ni.3799
|Nature Immunology 18/10||2020-03-17|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REGIREG" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "REGIREG" are provided by the European Opendata Portal: CORDIS opendata.
Discovery and Characterization of Hydrogen-Based High-Temperature SuperconductorsRead More
Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinomaRead More
The Enemy of the Good: Towards a Theory of Moral ProgressRead More