Opendata, web and dolomites

EYELETS SIGNED

A regenerative medicine approach in diabetes.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EYELETS project word cloud

Explore the words cloud of the EYELETS project. It provides you a very rough idea of what is the project "EYELETS" about.

tissue    diabetic    primates    anterior    regenerative    environment    homeostasis    islets    insulin    quality    transplanted    window    local    longitudinal    engineered    trial    medicine    treat    readout    performing    standardized    electronic    cell    follow    material    metabolic    transplantation    programs    treating    site    eye    favorable    technically    clinic    combat    animals    first    monitoring    chamber    optical    outcome    islet    cells    biology    pharmacological    micro    platform    blood    genetically    survival    optimized    transferred    human    cornea    grafts    trials    sensor    diabetes    mice    dependent    combined    treatment    pancreatic    engineering    synthetic    monitor    native    create    modulation    situ    validation    suitable    natural    strategies    instrumental    glucose    body    tailor    engrafted    varies    function    combine    difficult    invasive    superior    clinical    patient    fact    organoids    generate    hypothesize    ace   

Project "EYELETS" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00

Map

 Project objective

Pancreatic islet transplantation is essential for diabetes treatment. Outcome varies due to transplantation site, quality of islets and the fact that transplanted islets are affected by the same challenges as in situ islets. Tailor-making islets for transplantation by tissue engineering combined with a more favorable transplantation site that allows for both monitoring and local modulation of islet cells is thus instrumental. We have established the anterior chamber of the eye (ACE) as a favorable environment for long term survival of islet grafts and the cornea as a natural body window for non-invasive, longitudinal optical monitoring of islet function. ACE engrafted islets are able to maintain blood glucose homeostasis in diabetic animals. In addition to studies in non-human primates we are performing human clinical trials, the first patient already being transplanted. Tissue engineering of native islets is technically difficult. We will therefore apply genetically engineered islet organoids. This allows us to generate i) standardized material optimized for transplantation, function and survival, as well as ii) islet organoids suitable for monitoring (sensor islet organoids) and treating (metabolic islet organoids) insulin-dependent diabetes. We hypothesize that genetically engineered islet organoids transplanted to the ACE are superior to native pancreatic islets to monitor and treat insulin-dependent diabetes. Our overall aim is to create a platform allowing monitoring and treatment of insulin-dependent diabetes in mice that can be transferred to large animals for validation. The objective is to combine tissue engineering of islet cell organoids, transplantation to the ACE, synthetic biology, local pharmacological treatment strategies and the development of novel micro electronic/micro optical readout systems for islet cells. This regenerative medicine approach will follow our clinical trial programs and be transferred into the clinic to combat diabetes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EYELETS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EYELETS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SLAMseq (2019)

SLAMseq: Temporal resolution in gene expression profiling across multiple platforms

Read More  

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

BALANCE (2019)

Mapping Dispersion Spectroscopically in Large Gas-Phase Molecular Ions

Read More