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A regenerative medicine approach in diabetes.

Total Cost €


EC-Contrib. €






 EYELETS project word cloud

Explore the words cloud of the EYELETS project. It provides you a very rough idea of what is the project "EYELETS" about.

metabolic    treat    transferred    dependent    animals    difficult    window    fact    readout    tailor    regenerative    cell    clinic    ace    blood    pancreatic    human    sensor    diabetes    optimized    engineered    environment    treating    engrafted    suitable    transplanted    body    first    varies    platform    function    islets    strategies    longitudinal    treatment    survival    combat    situ    anterior    cells    combine    medicine    grafts    superior    patient    trial    validation    clinical    native    micro    programs    genetically    homeostasis    technically    create    transplantation    synthetic    electronic    trials    hypothesize    quality    combined    optical    biology    organoids    diabetic    chamber    local    engineering    monitor    cornea    tissue    performing    natural    material    insulin    standardized    eye    monitoring    primates    mice    site    favorable    outcome    generate    modulation    islet    invasive    glucose    follow    pharmacological    instrumental   

Project "EYELETS" data sheet

The following table provides information about the project.


Organization address
address: Nobels Vag 5
postcode: 17177

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00


 Project objective

Pancreatic islet transplantation is essential for diabetes treatment. Outcome varies due to transplantation site, quality of islets and the fact that transplanted islets are affected by the same challenges as in situ islets. Tailor-making islets for transplantation by tissue engineering combined with a more favorable transplantation site that allows for both monitoring and local modulation of islet cells is thus instrumental. We have established the anterior chamber of the eye (ACE) as a favorable environment for long term survival of islet grafts and the cornea as a natural body window for non-invasive, longitudinal optical monitoring of islet function. ACE engrafted islets are able to maintain blood glucose homeostasis in diabetic animals. In addition to studies in non-human primates we are performing human clinical trials, the first patient already being transplanted. Tissue engineering of native islets is technically difficult. We will therefore apply genetically engineered islet organoids. This allows us to generate i) standardized material optimized for transplantation, function and survival, as well as ii) islet organoids suitable for monitoring (sensor islet organoids) and treating (metabolic islet organoids) insulin-dependent diabetes. We hypothesize that genetically engineered islet organoids transplanted to the ACE are superior to native pancreatic islets to monitor and treat insulin-dependent diabetes. Our overall aim is to create a platform allowing monitoring and treatment of insulin-dependent diabetes in mice that can be transferred to large animals for validation. The objective is to combine tissue engineering of islet cell organoids, transplantation to the ACE, synthetic biology, local pharmacological treatment strategies and the development of novel micro electronic/micro optical readout systems for islet cells. This regenerative medicine approach will follow our clinical trial programs and be transferred into the clinic to combat diabetes.

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The information about "EYELETS" are provided by the European Opendata Portal: CORDIS opendata.

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