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EYELETS SIGNED

A regenerative medicine approach in diabetes.

Total Cost €

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EC-Contrib. €

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Partnership

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 EYELETS project word cloud

Explore the words cloud of the EYELETS project. It provides you a very rough idea of what is the project "EYELETS" about.

clinic    local    longitudinal    engineered    programs    technically    favorable    function    strategies    follow    readout    environment    varies    treating    monitoring    treat    monitor    optical    islet    anterior    genetically    site    tissue    animals    trial    combat    primates    diabetes    dependent    biology    superior    pancreatic    fact    validation    medicine    cell    transplanted    glucose    cornea    homeostasis    regenerative    window    material    grafts    quality    transplantation    tailor    synthetic    first    metabolic    modulation    standardized    body    combined    eye    hypothesize    create    suitable    human    generate    instrumental    chamber    organoids    cells    pharmacological    trials    blood    diabetic    electronic    difficult    native    survival    situ    combine    micro    platform    engrafted    insulin    invasive    optimized    natural    mice    islets    treatment    clinical    transferred    ace    performing    outcome    engineering    sensor    patient   

Project "EYELETS" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00

Map

 Project objective

Pancreatic islet transplantation is essential for diabetes treatment. Outcome varies due to transplantation site, quality of islets and the fact that transplanted islets are affected by the same challenges as in situ islets. Tailor-making islets for transplantation by tissue engineering combined with a more favorable transplantation site that allows for both monitoring and local modulation of islet cells is thus instrumental. We have established the anterior chamber of the eye (ACE) as a favorable environment for long term survival of islet grafts and the cornea as a natural body window for non-invasive, longitudinal optical monitoring of islet function. ACE engrafted islets are able to maintain blood glucose homeostasis in diabetic animals. In addition to studies in non-human primates we are performing human clinical trials, the first patient already being transplanted. Tissue engineering of native islets is technically difficult. We will therefore apply genetically engineered islet organoids. This allows us to generate i) standardized material optimized for transplantation, function and survival, as well as ii) islet organoids suitable for monitoring (sensor islet organoids) and treating (metabolic islet organoids) insulin-dependent diabetes. We hypothesize that genetically engineered islet organoids transplanted to the ACE are superior to native pancreatic islets to monitor and treat insulin-dependent diabetes. Our overall aim is to create a platform allowing monitoring and treatment of insulin-dependent diabetes in mice that can be transferred to large animals for validation. The objective is to combine tissue engineering of islet cell organoids, transplantation to the ACE, synthetic biology, local pharmacological treatment strategies and the development of novel micro electronic/micro optical readout systems for islet cells. This regenerative medicine approach will follow our clinical trial programs and be transferred into the clinic to combat diabetes.

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The information about "EYELETS" are provided by the European Opendata Portal: CORDIS opendata.

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