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EYELETS SIGNED

A regenerative medicine approach in diabetes.

Total Cost €

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EC-Contrib. €

0

Partnership

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 EYELETS project word cloud

Explore the words cloud of the EYELETS project. It provides you a very rough idea of what is the project "EYELETS" about.

electronic    anterior    material    quality    transferred    site    optimized    clinical    transplanted    ace    create    optical    instrumental    pharmacological    biology    eye    native    micro    programs    local    cell    cornea    clinic    primates    engineering    readout    diabetic    hypothesize    combined    trial    islet    insulin    situ    natural    treating    first    platform    superior    regenerative    dependent    engineered    animals    fact    function    varies    standardized    modulation    strategies    synthetic    window    tissue    survival    tailor    invasive    technically    environment    homeostasis    treat    performing    body    longitudinal    mice    metabolic    medicine    chamber    transplantation    suitable    monitoring    blood    trials    validation    engrafted    combat    difficult    islets    follow    monitor    combine    genetically    cells    organoids    pancreatic    patient    outcome    diabetes    human    favorable    sensor    glucose    generate    grafts    treatment   

Project "EYELETS" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00

Map

 Project objective

Pancreatic islet transplantation is essential for diabetes treatment. Outcome varies due to transplantation site, quality of islets and the fact that transplanted islets are affected by the same challenges as in situ islets. Tailor-making islets for transplantation by tissue engineering combined with a more favorable transplantation site that allows for both monitoring and local modulation of islet cells is thus instrumental. We have established the anterior chamber of the eye (ACE) as a favorable environment for long term survival of islet grafts and the cornea as a natural body window for non-invasive, longitudinal optical monitoring of islet function. ACE engrafted islets are able to maintain blood glucose homeostasis in diabetic animals. In addition to studies in non-human primates we are performing human clinical trials, the first patient already being transplanted. Tissue engineering of native islets is technically difficult. We will therefore apply genetically engineered islet organoids. This allows us to generate i) standardized material optimized for transplantation, function and survival, as well as ii) islet organoids suitable for monitoring (sensor islet organoids) and treating (metabolic islet organoids) insulin-dependent diabetes. We hypothesize that genetically engineered islet organoids transplanted to the ACE are superior to native pancreatic islets to monitor and treat insulin-dependent diabetes. Our overall aim is to create a platform allowing monitoring and treatment of insulin-dependent diabetes in mice that can be transferred to large animals for validation. The objective is to combine tissue engineering of islet cell organoids, transplantation to the ACE, synthetic biology, local pharmacological treatment strategies and the development of novel micro electronic/micro optical readout systems for islet cells. This regenerative medicine approach will follow our clinical trial programs and be transferred into the clinic to combat diabetes.

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The information about "EYELETS" are provided by the European Opendata Portal: CORDIS opendata.

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