Explore the words cloud of the SESE project. It provides you a very rough idea of what is the project "SESE" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙954˙633 €|
|EC max contribution||1˙954˙633 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-08-01 to 2021-07-31|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||1˙954˙633.00|
Micro-organisms were believed until recently to live independent, unicellular lives but are now understood to rely on complex systems of social behaviours for survival. In pathogenic bacteria, cooperation and communication between cells leads to increased virulence and the understanding of how these behaviours evolve is of fundamental importance to the future of human health. Almost nothing is known, however, about social behaviours of bacteria infecting human hosts, and research on social behaviour in microbes is limited to well-characterised lab strains. This proposal describes a program of research designed to exploit the opportunities offered by an interdisciplinary approach to address the growing challenge posed to human health by disease caused by bacterial infection. Specifically, I have three primary objectives: (1) to develop a model system for investigating social behaviour in long-term bacterial infections; (2) to identify evolutionary mechanisms driving dynamics of social behaviour in long-term infections and (3) to exploit social dynamics in the treatment of bacterial infection. This proposal applies evolutionary theory to the clinical challenge of bacterial infection to develop novel intervention strategies beyond the scope of conventional medicine, which is based primarily on understanding of bacteria at the cellular level.
|year||authors and title||journal||last update|
M Ghoul, SA West, FA McCorkell, Z Lee, JB Bruce, AS Griffin
Pyoverdin cheats fail to invade bacterial populations in stationary phase. Journal of Evolutionary Biology 9,
published pages: 1728-1736, ISSN: 1010-061X, DOI: 10.1111/jeb.12904
|Journal of Evolutionary Biology volume 9||2019-06-06|
Sandra B. Andersen, Melanie Ghoul, Ashleigh S. Griffin, Bent Petersen, Helle K. Johansen, SÃ¸ren Molin
Diversity, Prevalence, and Longitudinal Occurrence of Type II Toxin-Antitoxin Systems of Pseudomonas aeruginosa Infecting Cystic Fibrosis Lungs
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01180
|Frontiers in Microbiology 8||2019-06-06|
S Andersen, RL Marvig, S Molin, H Krogh Johansen, AS Griffin
Long-term social dynamics drive loss of function in pathogenic bacteria.
published pages: 10756-10761, ISSN: 0027-8424, DOI: 10.1073/pnas.1508324112
|Proceedings of the National Academy of Sciences USA vol 112||2019-06-06|
Melanie Ghoul, Stuart A. West, Helle Krogh Johansen, SÃ¸ren Molin, Odile B. Harrison, Martin C. J. Maiden, Lars Jelsbak, John B. Bruce, Ashleigh S. Griffin
Bacteriocin-mediated competition in cystic fibrosis lung infections
published pages: 20150972, ISSN: 0962-8452, DOI: 10.1098/rspb.2015.0972
|Proceedings of the Royal Society B: Biological Sciences 282/1814||2019-06-06|
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