Explore the words cloud of the STROMA project. It provides you a very rough idea of what is the project "STROMA" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||2˙547˙762 €|
|EC max contribution||2˙547˙762 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-10-01 to 2020-09-30|
Take a look of project's partnership.
|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||2˙386˙262.00|
|2||CHARITE - UNIVERSITAETSMEDIZIN BERLIN||DE (BERLIN)||participant||161˙500.00|
In 1984, Nossal wrote ‘‘A readership consisting of primarily anatomists has every right to question the favorite sport of research workers in cell immunology. This is to take a lymphoid tissue and totally destroy its beautiful and elaborately designed architecture to obtain simple cell suspension of lymphocytes, which are then asked to do more or less all the jobs of the original anatomic masterpiece’’. Growing evidence that lymph node (LN) stromal cells control the motility, activation and survival of lymphocytes has reinforced this view. These architectural cells assemble in 3D networks that regulate LN homeostasis and control its ability to remodel during inflammation. Understanding stromal cell biology is thus mandatory to our full comprehension of the immune system but this ambitious objective is technically challenging. As the complexity of the LN cannot be modelled in culture, knowledge gained from in vitro experiments is limited and will not address many relevant questions related to the biology of LN stromal cells, in particular (i) the elucidation of their origin and the precursor/product relationships that link them, (ii) the determination of their behavior in inflamed LNs and (iii) their subsequent fate in LNs that have returned to homeostasis. To this aim, I have developed several original, cutting-edge multicolor fluorescent reporter mouse models and computational modeling approaches to map the fate of single stromal cells and their progeny in situ. Using this innovative approach, my group will investigate the spatio-temporal behavior and molecular cues that orchestrate the development and dynamics of the major LN stromal cell populations in vivo, at steady state and under inflammatory conditions, at the single cell level. Because the proposed studies will unravel the precursor/product relationships linking the various stromal cell types, we anticipate to provide the first “Phylogenetic tree” of LN stromal cell development and remodeling.
|year||authors and title||journal||last update|
Alicia Bellomo, Rebecca Gentek, Marc BajÃ©noff, Myriam Baratin
Lymph node macrophages: Scavengers, immune sentinels and trophic effectors
published pages: , ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2018.01.010
ClÃ©ment Ghigo, Rebecca Gentek, Marc BajÃ©noff
Imaging the Lymph Node Stroma
published pages: 53-61, ISSN: , DOI: 10.1007/978-1-4939-7762-8_6
|Methods Mol Biol||2020-04-06|
Isabelle Mondor, Audrey Jorquera, Cynthia Sene, Sahil Adriouch, RalfÂ Heinrich Adams, Bin Zhou, Stephan Wienert, Frederick Klauschen, Marc BajÃ©noff
Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling
published pages: 877-888, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.09.017
Myriam Baratin, LÃ©a Simon, Audrey Jorquera, ClÃ©ment Ghigo, Doulaye Dembele, Jonathan Nowak, Rebecca Gentek, Stephan Wienert, Frederick Klauschen, Bernard Malissen, Marc Dalod, Marc BajÃ©noff
T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node
published pages: 349-362.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.07.019
Rebecca Gentek, Marc BajÃ©noff
Lymph Node Stroma Dynamics and Approaches for Their Visualization
published pages: 236-247, ISSN: 1471-4906, DOI: 10.1016/j.it.2017.01.005
|Trends in Immunology 38/4||2020-04-06|
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