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STROMA SIGNED

IMMUNOBIOLOGY OF LYMPHOID STROMAL CELLS

Total Cost €

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EC-Contrib. €

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Partnership

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 STROMA project word cloud

Explore the words cloud of the STROMA project. It provides you a very rough idea of what is the project "STROMA" about.

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Project "STROMA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.ciml.univ-mrs.fr/science/lab-marc-bajenoff/stromal-cell-immunobiology-0
 Total cost 2˙547˙762 €
 EC max contribution 2˙547˙762 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 2˙386˙262.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 161˙500.00

Map

 Project objective

In 1984, Nossal wrote ‘‘A readership consisting of primarily anatomists has every right to question the favorite sport of research workers in cell immunology. This is to take a lymphoid tissue and totally destroy its beautiful and elaborately designed architecture to obtain simple cell suspension of lymphocytes, which are then asked to do more or less all the jobs of the original anatomic masterpiece’’. Growing evidence that lymph node (LN) stromal cells control the motility, activation and survival of lymphocytes has reinforced this view. These architectural cells assemble in 3D networks that regulate LN homeostasis and control its ability to remodel during inflammation. Understanding stromal cell biology is thus mandatory to our full comprehension of the immune system but this ambitious objective is technically challenging. As the complexity of the LN cannot be modelled in culture, knowledge gained from in vitro experiments is limited and will not address many relevant questions related to the biology of LN stromal cells, in particular (i) the elucidation of their origin and the precursor/product relationships that link them, (ii) the determination of their behavior in inflamed LNs and (iii) their subsequent fate in LNs that have returned to homeostasis. To this aim, I have developed several original, cutting-edge multicolor fluorescent reporter mouse models and computational modeling approaches to map the fate of single stromal cells and their progeny in situ. Using this innovative approach, my group will investigate the spatio-temporal behavior and molecular cues that orchestrate the development and dynamics of the major LN stromal cell populations in vivo, at steady state and under inflammatory conditions, at the single cell level. Because the proposed studies will unravel the precursor/product relationships linking the various stromal cell types, we anticipate to provide the first “Phylogenetic tree” of LN stromal cell development and remodeling.

 Publications

year authors and title journal last update
List of publications.
2018 Alicia Bellomo, Rebecca Gentek, Marc Bajénoff, Myriam Baratin
Lymph node macrophages: Scavengers, immune sentinels and trophic effectors
published pages: , ISSN: 0008-8749, DOI: 10.1016/j.cellimm.2018.01.010
Cellular Immunology 2020-04-06
2018 Clément Ghigo, Rebecca Gentek, Marc Bajénoff
Imaging the Lymph Node Stroma
published pages: 53-61, ISSN: , DOI: 10.1007/978-1-4939-7762-8_6
Methods Mol Biol 2020-04-06
2016 Isabelle Mondor, Audrey Jorquera, Cynthia Sene, Sahil Adriouch, Ralf Heinrich Adams, Bin Zhou, Stephan Wienert, Frederick Klauschen, Marc Bajénoff
Clonal Proliferation and Stochastic Pruning Orchestrate Lymph Node Vasculature Remodeling
published pages: 877-888, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2016.09.017
Immunity 45/4 2020-04-06
2017 Myriam Baratin, Léa Simon, Audrey Jorquera, Clément Ghigo, Doulaye Dembele, Jonathan Nowak, Rebecca Gentek, Stephan Wienert, Frederick Klauschen, Bernard Malissen, Marc Dalod, Marc Bajénoff
T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node
published pages: 349-362.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.07.019
Immunity 47/2 2020-04-06
2017 Rebecca Gentek, Marc Bajénoff
Lymph Node Stroma Dynamics and Approaches for Their Visualization
published pages: 236-247, ISSN: 1471-4906, DOI: 10.1016/j.it.2017.01.005
Trends in Immunology 38/4 2020-04-06

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