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CaSR Biomedicine SIGNED

Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

Total Cost €

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EC-Contrib. €

0

Partnership

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 CaSR Biomedicine project word cloud

Explore the words cloud of the CaSR Biomedicine project. It provides you a very rough idea of what is the project "CaSR Biomedicine" about.

therapeutic    dependent    scientists    depending    sarcopenia    physiological    biology    sensing    gt    plays    systemic    function    receptor    biomedicine    lasting    scientific    subtypes    interacts    ion    diabetes    cooperation    expression    expressed    metabolism    abnormal    disorders    elucidate    cellular    researchers    ad    innovative    14    urinary    downstream    gprotein    train    stage    parathyroid    excretion    age    gpcr    molecule    25    cancer    coupled    regulating    career    altered    ca2    ca    educate    functions    burden    physiology    pivotal    interdisciplinary    context    complexity    principal    industry    calciotropic    differences    preparing    ligand    divergent    alpha    specialists    ubiquitously    training    hormone    tissue    young    intersectoral    implicated    dm    diseases    perspective    linked    single    multiple    strengthen    cardiovascular    almost    signalling    class    disease    global    cvd    casr    secretion    area    influencing    alzheimer    translational    multidisciplinary    calcium    utilises   

Project "CaSR Biomedicine" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://casr.meduniwien.ac.at/
 Total cost 3˙657˙194 €
 EC max contribution 3˙657˙194 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 511˙868.00
2    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 290˙081.00
3    CARDIFF UNIVERSITY UK (CARDIFF) participant 273˙287.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 273˙287.00
5    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 273˙287.00
6    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 273˙287.00
7    UNIVERSITE DE PICARDIE JULES VERNE FR (AMIENS) participant 262˙875.00
8    S.A.F.AN. BIOINFORMATICS - SAS DI PUGLIESE LUISA IT (TORINO) participant 258˙061.00
9    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 258˙061.00
10    TISSUEGNOSTICS GMBH AT (VIENNA) participant 255˙934.00
11    STICHTING VU NL (AMSTERDAM) participant 255˙374.00
12    FUNDACIO SANT JOAN DE DEU ES (Esplugues de Llobregat) participant 247˙872.00
13    BIOTALENTUM TUDASFEJLESZTO KFT HU (GOEDOELLO) participant 223˙913.00
14    AHT-Management HU (Budapest) partner 0.00
15    Amgen GmbH AT (Wien) partner 0.00
16    FH JOANNEUM GESELLSCHAFT MBH AT (GRAZ) partner 0.00
17    IMABIOTECH SAS FR (LOOS) partner 0.00
18    NOVARTIS PHARMA AG CH (BASEL) partner 0.00

Map

 Project objective

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2 ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling. The objectives of CaSR Biomedicine are: 1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective. 2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general; 3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders. 4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area. Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

 Deliverables

List of deliverables.
Public domain of the webpage on-line Websites, patent fillings, videos etc. 2019-07-10 13:01:37
Vacancies advertised Other 2019-07-10 13:01:37
3rd ETN School held Other 2019-07-10 13:01:37
First newsletter Other 2019-07-10 13:01:37
Second Newsletter Other 2019-07-10 13:01:37
First ETN School held Other 2019-07-10 13:01:37
2nd ETN school held Other 2019-07-10 13:01:37
International CaSR Symposium Other 2019-07-10 13:01:37

Take a look to the deliverables list in detail:  detailed list of CaSR Biomedicine deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Marta García, Carlos Javier Rodríguez‐Hernández, Silvia Mateo‐Lozano, Sara Pérez‐Jaume, Eliana Gonçalves‐Alves, Cinzia Lavarino, Jaume Mora, Carmen Torres
Parathyroid hormone‐like hormone plays a dual role in neuroblastoma depending on PTH 1R expression
published pages: 1959-1975, ISSN: 1574-7891, DOI: 10.1002/1878-0261.12542
Molecular Oncology 13/9 2020-04-24
2020 Souvik Das, Philippe Clézardin, Said Kamel, Michel Brazier, Romuald Mentaverri
The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2020.00069
Frontiers in Oncology 10 2020-04-24
2019 Maria Lo Giudice, Balázs Mihalik, András Dinnyés, Julianna Kobolák
The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease
published pages: 2546, ISSN: 1420-3049, DOI: 10.3390/molecules24142546
Molecules 24/14 2019-08-29
2019 Iris Mos, Stine E. Jacobsen, Simon Foster, Hans Brauner-Osborne
Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands
published pages: mol.119.116772, ISSN: 0026-895X, DOI: 10.1124/mol.119.116772
Molecular Pharmacology 2019-08-29
2016 Isabella Ellinger
The Calcium-Sensing Receptor and the Reproductive System
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00371
Frontiers in Physiology 7 2019-07-10
2018 Enikö Kallay
Editorial: Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.00413
Frontiers in Physiology 9 2019-07-10

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