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ModLife SIGNED

Advancing Modelling for Process-Product Innovation, Optimization, Monitoring and Control in Life Science Industries

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ModLife" data sheet

The following table provides information about the project.

Coordinator
DANMARKS TEKNISKE UNIVERSITET 

Organization address
address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A
city: KGS LYNGBY
postcode: 2800
website: www.dtu.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://modlife.eu
 Total cost 4˙090˙249 €
 EC max contribution 4˙090˙249 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) coordinator 870˙245.00
2    ALFA LAVAL COPENHAGEN A/S DK (SOEBERG) participant 580˙163.00
3    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 546˙575.00
4    UNIVERSITY OF STRATHCLYDE UK (GLASGOW) participant 546˙575.00
5    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) participant 525˙751.00
6    RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN DE (AACHEN) participant 498˙432.00
7    UNILEVER U.K. CENTRAL RESOURCES LIMITED UK (LONDON) participant 273˙287.00
8    BAYER AKTIENGESELLSCHAFT DE (Leverkusen) participant 249˙216.00
9    BAYER TECHNOLOGY SERVICES GMBH DE (LEVERKUSEN) participant 0.00
10    ART PHOTONICS DE (BERLIN) partner 0.00
11    JANSSEN PHARMACEUTICA NV BE (BEERSE) partner 0.00
12    S-PACT DE (AACHEN) partner 0.00

Map

 Project objective

The ModLife project is a European Training Network initiative that brings together 5 leading European universities, 4 global industrial players and 2 SMEs to undertake research and training in the area of product-process innovation, optimization monitoring and control for life sciences and biotechnology industries. Modlife aims to develop Advanced Model-Based Optimization, Monitoring and Control as Enabling Technologies for bioprocess-product development and innovation tailored for the needs in life science industries. ModLife ETN will address excellence in research and training of next generation biochemical and process engineers in life sciences industries through: (1) Offering comprehensive training and knowledge transfer opportunities in multidisciplinary and multi-sectoral fields for training early stage researchers with multidisciplinary knowledge and competences bridging engineering and life sciences (2) Integrating and creating synergies among individually excellent but otherwise fragmented bioprocess engineering research centers across the European union in life sciences and biotechnology industries, (3) Building on advances in modeling and simulation, to develop cutting edge model-based enabling technologies and applications for optimization, monitoring and control for bioprocess and product development and innovation. The ModLife ETN aims at next generation of high performance computing tools and in-situ measurements for increasing efficiency, innovation and competitiveness of Europe’s life sciences and processing industries. Ultimately Modlife aims to help Europe realize the promising potential of life sciences and biotechnology- considered the next frontier technologies with profound impacts to knowledge based economy, by building the capacity to translate lab-scale life science discoveries to large scale new products and processes to match the human needs for health, nutrition and wellbeing.

 Deliverables

List of deliverables.
property model library and database Documents, reports 2020-04-09 09:14:45
Control bioprocess Documents, reports 2020-04-09 09:14:45
Healthcare products formulated Documents, reports 2020-04-09 09:14:45
Oleochemicals process designed Documents, reports 2020-04-09 09:14:45
PG certificate Documents, reports 2020-04-09 09:14:45
Integrated MD & phase equilibrium models Documents, reports 2020-04-09 09:14:45
Data fusion Documents, reports 2020-04-09 09:14:45
Sustainable process design Documents, reports 2020-04-09 09:14:45
multicentre PhD training Documents, reports 2020-04-09 09:14:45
Multi-scale models Documents, reports 2020-04-09 09:14:45
Methodology Documents, reports 2020-04-09 09:14:44
In situ measurement Documents, reports 2020-04-09 09:14:44

Take a look to the deliverables list in detail:  detailed list of ModLife deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Eduardo S. Schultz, Ralf Hannemann-Tamás, Alexander Mitsos
Guaranteed satisfaction of inequality state constraints in PDE-constrained optimization
published pages: 108653, ISSN: 0005-1098, DOI: 10.1016/j.automatica.2019.108653
Automatica 111 2020-04-09
2020 Hector Forero-Hernandez, Mark Nicholas Jones, Bent Sarup, Anker Degn Jensen, Jens Abildskov, Gürkan Sin
Comprehensive development, uncertainty and sensitivity analysis of a model for the hydrolysis of rapeseed oil
published pages: 106631, ISSN: 0098-1354, DOI: 10.1016/j.compchemeng.2019.106631
Computers & Chemical Engineering 133 2020-04-09
2019 Mark Jones, Hector Forero-Hernandez, Alexandr Zubov, Bent Sarup, Gürkan Sin
Splitting Triglycerides with a Counter-Current Liquid–Liquid Spray Column: Modeling, Global Sensitivity Analysis, Parameter Estimation and Optimization
published pages: 881, ISSN: 2227-9717, DOI: 10.3390/pr7120881
Processes 7/12 2020-04-09
2019 Simon Olofsson, Lukas Hebing, Sebastian Niedenführ, Marc Peter Deisenroth, Ruth Misener
GPdoemd: A Python package for design of experiments for model discrimination
published pages: 54-70, ISSN: 0098-1354, DOI: 10.1016/j.compchemeng.2019.03.010
Computers & Chemical Engineering 125 2020-04-09
2019 Mark Nicholas Jones, Jérôme Frutiger, Nevin Gerek Ince, Gürkan Sin
The Monte Carlo driven and machine learning enhanced process simulator
published pages: 324-338, ISSN: 0098-1354, DOI: 10.1016/j.compchemeng.2019.03.016
Computers & Chemical Engineering 125 2020-04-09
2019 Resul Al, Chitta Ranjan Behera, Alexandr Zubov, Krist V. Gernaey, Gürkan Sin
Meta-modeling based efficient global sensitivity analysis for wastewater treatment plants – An application to the BSM2 model
published pages: 233-246, ISSN: 0098-1354, DOI: 10.1016/j.compchemeng.2019.05.015
Computers & Chemical Engineering 127 2020-04-09
2019 Puneet Mishra, Azam Karami, Alison Nordon, Douglas N. Rutledge, Jean-Michel Roger
Automatic de-noising of close-range hyperspectral images with a wavelength-specific shearlet-based image noise reduction method
published pages: 1034-1044, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.11.034
Sensors and Actuators B: Chemical 281 2020-04-09
2019 Puneet Mishra, Alison Nordon, Mohd Shahrimie Mohd Asaari, Guoping Lian, Sally Redfern
Fusing spectral and textural information in near-infrared hyperspectral imaging to improve green tea classification modelling
published pages: 40-47, ISSN: 0260-8774, DOI: 10.1016/J.JFOODENG.2019.01.009
Journal of Food Engineering 249 2020-04-09
2019 Antonio L. Grilo, Athanasios Mantalaris
Apoptosis: A mammalian cell bioprocessing perspective
published pages: 459-475, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2019.02.012
Biotechnology Advances 37/3 2020-04-09
2019 Mishra P., Feller T., Schmuck M., Nicol A., Nordon A.
Early detection of drought stress in Arabidopsis Thaliana utilising a portable hyperspectral imaging setup
published pages: , ISSN: , DOI:
2020-04-09
2019 Mishra P., Schmuck M., Roth S., Nicol A., Nordon A.
Homogenising and segmenting hyperspectral images of plants and testing chemicals in a high-throughput phenotyping setup
published pages: , ISSN: , DOI:
2020-04-09
2019 Mattia Turchi, Qiong Cai, Guoping Lian
An evaluation of in-silico methods for predicting solute partition in multiphase complex fluids – A case study of octanol/water partition coefficient
published pages: 150-158, ISSN: 0009-2509, DOI: 10.1016/j.ces.2018.12.003
Chemical Engineering Science 197 2020-04-09
2019 Behnam Khadem, Nida Sheibat-Othman
Modeling of double emulsions using population balance equations
published pages: 587-597, ISSN: 1385-8947, DOI: 10.1016/j.cej.2019.02.092
Chemical Engineering Journal 366 2020-04-09
2019 Behnam Khadem, Nida Sheibat-Othman
Theoretical and Experimental Investigations of Double Emulsion Preparation by Ultrasonication
published pages: 8220-8230, ISSN: 0888-5885, DOI: 10.1021/acs.iecr.9b00556
Industrial & Engineering Chemistry Research 58/19 2020-04-09
2018 Chrysoula D. Kappatou, Adel Mhamdi, Ana Quiroga Campano, Athanasios Mantalaris, Alexander Mitsos
Model-Based Dynamic Optimization of Monoclonal Antibodies Production in Semibatch Operation—Use of Reformulation Techniques
published pages: 9915-9924, ISSN: 0888-5885, DOI: 10.1021/acs.iecr.7b05357
Industrial & Engineering Chemistry Research 57/30 2020-04-09
2019 Mattia Turchi, Qiong Cai, Guoping Lian
In Silico Prediction of the Thermodynamic Equilibrium of Solute Partition in Multiphase Complex Fluids: A Case Study of Oil–Water Microemulsion
published pages: 10855-10865, ISSN: 0743-7463, DOI: 10.1021/acs.langmuir.9b01513
Langmuir 35/33 2020-04-09
2019 António L. Grilo, Athanasios Mantalaris
A Predictive Mathematical Model of Cell Cycle, Metabolism, and Apoptosis of Monoclonal Antibody‐Producing GS–NS0 Cells
published pages: 1800573, ISSN: 1860-6768, DOI: 10.1002/biot.201800573
Biotechnology Journal 2020-04-09
2018 Mohammad Mehrian, Yann Guyot, Ioannis Papantoniou, Simon Olofsson, Maarten Sonnaert, Ruth Misener, Liesbet Geris
Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization
published pages: 617-629, ISSN: 0006-3592, DOI: 10.1002/bit.26500
Biotechnology and Bioengineering 115/3 2020-04-09
2018 Olofsson, Simon; Deisenroth, Marc Peter; Misener, Ruth
Design of Experiments for Model Discrimination Hybridising Analytical and Data-Driven Approaches
published pages: , ISSN: 1938-7228, DOI:
Proceedings of the 35th International Conference on Machine Learning, PMLR 2020-04-09
2020 Behnam Khadem, Maya Khellaf, Nida Sheibat-Othman
Investigating swelling-breakdown in double emulsions
published pages: 124181, ISSN: 0927-7757, DOI: 10.1016/j.colsurfa.2019.124181
Colloids and Surfaces A: Physicochemical and Engineering Aspects 585 2020-04-09
2020 Behnam Khadem, Nida Sheibat-Othman
Modeling droplets swelling and escape in double emulsions using population balance equations
published pages: 122824, ISSN: 1385-8947, DOI: 10.1016/j.cej.2019.122824
Chemical Engineering Journal 382 2020-04-09
2019 Simon Olofsson, Mohammad Mehrian, Roberto Calandra, Liesbet Geris, Marc Peter Deisenroth, Ruth Misener
Bayesian Multiobjective Optimisation With Mixed Analytical and Black-Box Functions: Application to Tissue Engineering
published pages: 727-739, ISSN: 0018-9294, DOI: 10.1109/tbme.2018.2855404
IEEE Transactions on Biomedical Engineering 66/3 2020-04-09

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