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SGCR SIGNED

Systematic Genetic Code Reprogramming

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "SGCR" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙475˙344 €
 EC max contribution 2˙475˙344 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 2˙475˙344.00
2    MEDICAL RESEARCH COUNCIL UK (SWINDON) coordinator 0.00

Map

 Project objective

We will build an orthogonal translation system for the encoded synthesis of unnatural polymers in cells. The steps towards this goal are each significant and substantial and, importantly, our solutions for each step are both scalable and modular with those for other steps in the process. In the first step we create a scalable and modular route to multiple new aminoacyl-tRNA synthetase/tRNA pairs that are orthogonal to each other and to endogenous synthetases and tRNAs. In a second step we engineer a cell for orthogonal translation to enable each orthogonal tRNA to quantitatively and efficiently decode a distinct quadruplet codon. In a third step we invent a modular and scalable route to program the active sites of mutually orthogonal synthetases to uniquely recognize distinct unnatural building blocks. The modular combination of the advances in each step enables the conversion of genetic code expansion with one or two unnatural amino acids into a scalable technology for genetic code reprogramming, facilitating the encoded synthesis of unnatural polymers using a synthetic genetic code with more encoded monomers than the natural genetic code.

 Publications

year authors and title journal last update
List of publications.
2017 Michael Shaofei Zhang, Simon F Brunner, Nicolas Huguenin-Dezot, Alexandria Deliz Liang, Wolfgang H Schmied, Daniel T Rogerson, Jason W Chin
Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing
published pages: 729-736, ISSN: 1548-7091, DOI: 10.1038/nmeth.4302
Nature Methods 14/7 2019-04-03
2018 Julian C. W. Willis, Jason W. Chin
Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs
published pages: 831-837, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0052-5
Nature Chemistry 10/8 2019-04-03
2016 Kaihang Wang, Julius Fredens, Simon F. Brunner, Samuel H. Kim, Tiongsun Chia, Jason W. Chin
Defining synonymous codon compression schemes by genome recoding
published pages: 59-64, ISSN: 0028-0836, DOI: 10.1038/nature20124
Nature 539/7627 2019-04-03

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The information about "SGCR" are provided by the European Opendata Portal: CORDIS opendata.

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