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Insomnia’s Negative Sequelae On Mood: from Neuroscience to Intervention in the Aged

Total Cost €


EC-Contrib. €






 INSOMNIA project word cloud

Explore the words cloud of the INSOMNIA project. It provides you a very rough idea of what is the project "INSOMNIA" about.

health    insomnia    risks    exist    prognosis    obstructed    strategies    respect    psychological    population    ageing    pioneering    behavioural    mechanisms    prevent    symptoms    interdisciplinary    detected    home    data    habits    ignorance    hazards    policies    chance    identification    frequent    traits    exposures    moderate    quantification    rational    structure    disorders    protocols    intervention    unconventional    modifiable    multivariate    mechanistic    strongest    applicable    extends    imaging    clinically    elderly    brain    additional    promise    unprecedented    enrolling    effectiveness    heterogeneity       improvement    develops    combat    stresses    poor    13    meta    risk    burdening    progress    identifies    profiles    sleep    environmental    internet    extreme    subtypes    differ    trait    burden    prevention    optimizes    treatment    urgency    innovative    depression    subtype    function    insomniacs    40    preventive    shows    estimates    16    global    interventions    people    unfortunately    major    discriminated    20    prevalence   

Project "INSOMNIA" data sheet

The following table provides information about the project.


Organization address
postcode: 1011 JV

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙867˙360 €
 EC max contribution 1˙867˙360 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Major depression is among the most burdening health hazards. Its prevalence is 1-3%, an additional 8-16% have clinically significant symptoms, and prognosis is poor. Unfortunately, less than 20% of the cases are detected and treatment effectiveness is moderate. The Global Consortium for Depression Prevention stresses that our best chance to combat the global burden of depression is provide preventive intervention to identified people at risk. This project targets the strongest modifiable risk factor: insomnia. With prevalence estimates up to 40%, insomnia is among the most frequent disorders in the elderly population. Meta-analysis shows that no less than 13% of people with insomnia develop depression. This extreme risk and the very high prevalence of insomnia in the ageing population, shows the urgency and promise of: (1) early identification of these 13%, (2) finding mechanisms by quantification of how they differ from insomniacs that do not develop depression with respect to brain structure and function, psychological traits, behavioural habits and environmental exposures; and (3) enrolling them in intervention protocols aimed at sleep improvement and prevention of depression. The project extends recent findings emerging from the applicant’s pioneering, unconventional and innovative approach to insomnia; the proposal that distinct subtypes exist and can be discriminated data-driven by means of multivariate trait analysis and brain imaging. Ignorance of this heterogeneity has obstructed progress in mechanistic understanding and rational treatment. In an unprecedented interdisciplinary way the project (1) identifies the insomnia subtype that develops depression; (2) profiles mechanisms involved; and (3) optimizes effectiveness of internet-supported home-applicable interventions to improve sleep and prevent depression. This approach will identify risks and mechanisms, and facilitate immediate implementation of risk-based prevention strategies and policies.


year authors and title journal last update
List of publications.
2019 Yishul Wei, Jeanne Leerssen, Rick Wassing, Diederick Stoffers, Joy Perrier, Eus J. W. Van Someren
Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
published pages: , ISSN: 0962-1105, DOI: 10.1111/jsr.12953
Journal of Sleep Research 2020-01-29
2019 Bart H. W. Lindert, Tessa F. Blanken, Wisse P. Meijden, Kim Dekker, Rick Wassing, Ysbrand D. Werf, Jennifer R. Ramautar, Eus J. W. Van Someren
Actigraphic multi‐night home‐recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers
published pages: , ISSN: 0962-1105, DOI: 10.1111/jsr.12937
Journal of Sleep Research 2020-01-29
2019 Tessa F Blanken, Denny Borsboom, Brenda Wjh Penninx, Eus Jw Van Someren
Network outcome analysis identifies difficulty initiating sleep as a primary target for prevention of depression: a 6-year prospective study
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsz288
Sleep 2020-01-29
2020 Yishul Wei, Eus JW Van Someren
Interoception relates to sleep and sleep disorders
published pages: 1-7, ISSN: 2352-1546, DOI: 10.1016/j.cobeha.2019.11.008
Current Opinion in Behavioral Sciences 33 2020-01-29
2019 Shadi Bagherzadeh-Azbari, Habibolah Khazaie, Mojtaba Zarei, Kai Spiegelhalder, Martin Walter, Jeanne Leerssen, Eus J.W. Van Someren, Amir A. Sepehry, Masoud Tahmasian
Neuroimaging insights into the link between depression and Insomnia: A systematic review
published pages: 133-143, ISSN: 0165-0327, DOI: 10.1016/j.jad.2019.07.089
Journal of Affective Disorders 258 2020-01-29
2019 Yishul Wei, Tom Bresser, Rick Wassing, Diederick Stoffers, Eus J.W. Van Someren, Jessica C. Foster-Dingley
Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
published pages: 102019, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.102019
NeuroImage: Clinical 24 2020-01-29
2019 Rick Wassing, Frans Schalkwijk, Oti Lakbila-Kamal, Jennifer R Ramautar, Diederick Stoffers, Henri J M M Mutsaerts, Lucia M Talamini, Eus J W Van Someren
Haunted by the past: old emotions remain salient in insomnia disorder
published pages: 1783-1796, ISSN: 0006-8950, DOI: 10.1093/brain/awz089
Brain 142/6 2019-08-30
2019 Jacob Itzhacki, Bart H. W. te Lindert, Wisse P. van der Meijden, Morten L. Kringelbach, Jorge Mendoza, Eus J. W. Van Someren
Environmental light and time of day modulate subjective liking and wanting.
published pages: 10-20, ISSN: 1528-3542, DOI: 10.1037/emo0000402
Emotion 19/1 2019-08-30
2019 Rick Wassing, Oti Lakbila-Kamal, Jennifer R. Ramautar, Diederick Stoffers, Frans Schalkwijk, Eus J.W. Van Someren
Restless REM Sleep Impedes Overnight Amygdala Adaptation
published pages: 2351-2358.e4, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.06.034
Current Biology 29/14 2019-08-30
2018 Masoud Tahmasian, Khadijeh Noori, Fateme Samea, Mojtaba Zarei, Kai Spiegelhalder, Simon B. Eickhoff, Eus Van Someren, Habibolah Khazaie, Claudia R. Eickhoff
A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis
published pages: 111-118, ISSN: 1087-0792, DOI: 10.1016/j.smrv.2018.07.004
Sleep Medicine Reviews 42 2019-08-30
2019 Frans Schalkwijk, Eus J.W. Van Someren, Rick Wassing
A clinical interpretation of shame regulation in maladaptive perfectionism
published pages: 19-23, ISSN: 0191-8869, DOI: 10.1016/j.paid.2018.09.001
Personality and Individual Differences 138 2019-08-30
2019 Jeanne Leerssen, Rick Wassing, Jennifer R. Ramautar, Diederick Stoffers, Oti Lakbila-Kamal, Joy Perrier, Jessica Bruijel, Jessica C. Foster-Dingley, Moji Aghajani, Eus J.W. van Someren
Increased hippocampal-prefrontal functional connectivity in insomnia
published pages: 144-150, ISSN: 1074-7427, DOI: 10.1016/j.nlm.2018.02.006
Neurobiology of Learning and Memory 160 2019-08-30
2019 Philip R. Jansen, Kyoko Watanabe, Sven Stringer, Nathan Skene, Julien Bryois, Anke R. Hammerschlag, Christiaan A. de Leeuw, Jeroen S. Benjamins, Ana B. Muñoz-Manchado, Mats Nagel, Jeanne E. Savage, Henning Tiemeier, Tonya White, Joyce Y. Tung, David A. Hinds, Vladimir Vacic, Xin Wang, Patrick F. Sullivan, Sophie van der Sluis, Tinca J. C. Polderman, August B. Smit, Jens Hjerling-Leffler, Eus J. W
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
published pages: 394-403, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0333-3
Nature Genetics 51/3 2019-08-30
2018 Jacob Itzhacki, Daniel Clesse, Yannick Goumon, Eus J. Van Someren, Jorge Mendoza
Light rescues circadian behavior and brain dopamine abnormalities in diurnal rodents exposed to a winter-like photoperiod
published pages: 2641-2652, ISSN: 1863-2653, DOI: 10.1007/s00429-018-1655-8
Brain Structure and Function 223/6 2019-08-30
2018 Bart H W te Lindert, Jacob Itzhacki, Wisse P van der Meijden, Morten L Kringelbach, Jorge Mendoza, Eus J W Van Someren
Bright environmental light ameliorates deficient subjective ‘liking’ in insomnia: an experience sampling study
published pages: zsy022, ISSN: 0161-8105, DOI: 10.1093/sleep/zsy022
Sleep 41/4 2019-08-30
2018 Masoud Tahmasian, Mojtaba Zarei, Khadijeh Noori, Habibolah Khazaie, Fateme Samea, Kai Spiegelhalder, Simon B. Eickhoff, Eus Van Someren, Claudia R. Eickhoff
Reply to Hua Liu, HaiCun Shi and PingLei Pan: Coordinate based meta-analyses in a medium sized literature: Considerations, limitations and road ahead
published pages: 236-238, ISSN: 1087-0792, DOI: 10.1016/j.smrv.2018.08.004
Sleep Medicine Reviews 42 2019-08-30
2018 Rick Wassing, Jeroen S Benjamins, Lucia M Talamini, Frans Schalkwijk, Eus J W Van Someren
Overnight worsening of emotional distress indicates maladaptive sleep in insomnia
published pages: zsy268, ISSN: 0161-8105, DOI: 10.1093/sleep/zsy268
Sleep 42/4 2019-08-30
2015 E. J. W. Van Someren, C. Cirelli, D.-J. Dijk, E. Van Cauter, S. Schwartz, M. W. L. Chee
Disrupted Sleep: From Molecules to Cognition
published pages: 13889-13895, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2592-15.2015
Journal of Neuroscience 35/41 2019-07-08
2016 Jeroen S. Benjamins, Filippo Migliorati, Kim Dekker, Rick Wassing, Sarah Moens, Tessa F. Blanken, Bart H.W. te Lindert, Jeffrey Sjauw Mook, Eus J.W. Van Someren
Insomnia heterogeneity: characteristics to consider for data-driven multivariate subtyping
published pages: , ISSN: 1087-0792, DOI: 10.1016/j.smrv.2016.10.005
Sleep Medicine Reviews 2019-07-08
2016 B. Alexander Diaz, Richard Hardstone, Huibert D. Mansvelder, Eus J. W. Van Someren, Klaus Linkenkaer-Hansen
Resting-State Subjective Experience and EEG Biomarkers Are Associated with Sleep-Onset Latency
published pages: 492, ISSN: 1664-1078, DOI: 10.3389/fpsyg.2016.00492
Frontiers in Psychology 7 2019-07-08
2016 Tanja van der Zweerde, Jaap Lancee, Pauline Slottje, Judith Bosmans, Eus Van Someren, Charles Reynolds, Pim Cuijpers, Annemieke van Straten
Cost-effectiveness of i-Sleep, a guided online CBT intervention, for patients with insomnia in general practice: protocol of a pragmatic randomized controlled trial
published pages: 85, ISSN: 1471-244X, DOI: 10.1186/s12888-016-0783-z
BMC Psychiatry 16/1 2019-07-08
2017 Giovanni Piantoni, Nico Romeijn, German Gomez-Herrero, Ysbrand D. Van Der Werf, Eus J. W. Van Someren
Alpha Power Predicts Persistence of Bistable Perception
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-05610-8
Scientific Reports 7/1 2019-07-08
2016 Michele A. Colombo, Yishul Wei, Jennifer R. Ramautar, Klaus Linkenkaer-Hansen, Enzo Tagliazucchi, Eus J. W. Van Someren
More Severe Insomnia Complaints in People with Stronger Long-Range Temporal Correlations in Wake Resting-State EEG
published pages: 576, ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00576
Frontiers in Physiology 7 2019-07-08
2016 Yishul Wei, Jennifer R. Ramautar, Michele A. Colombo, Diederick Stoffers, Germ?n G?mez-Herrero, Wisse P. van der Meijden, Bart H.W. te Lindert, Ysbrand D. van der Werf, Eus J.W. Van Someren
I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia
published pages: 2113-2124, ISSN: 0161-8105, DOI: 10.5665/sleep.6308
SLEEP 39/12 2019-07-08
2016 Rick Wassing, Jeroen S. Benjamins, Kim Dekker, Sarah Moens, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Sophie van der Sluis, Ysbrand D. Van Der Werf, Lucia M. Talamini, Matthew P. Walker, Frans Schalkwijk, Eus J. W. Van Someren
Slow dissolving of emotional distress contributes to hyperarousal
published pages: 2538-2543, ISSN: 0027-8424, DOI: 10.1073/pnas.1522520113
Proceedings of the National Academy of Sciences 113/9 2019-07-08
2017 Kim Dekker, Tessa Blanken, Eus Van Someren
Insomnia and Personality—A Network Approach
published pages: 28, ISSN: 2076-3425, DOI: 10.3390/brainsci7030028
Brain Sciences 7/3 2019-07-08
2017 Anke R Hammerschlag, Sven Stringer, Christiaan A de Leeuw, Suzanne Sniekers, Erdogan Taskesen, Kyoko Watanabe, Tessa F Blanken, Kim Dekker, Bart H W te Lindert, Rick Wassing, Ingileif Jonsdottir, Gudmar Thorleifsson, Hreinn Stefansson, Thorarinn Gislason, Klaus Berger, Barbara Schormair, Juergen Wellmann, Juliane Winkelmann, Kari Stefansson, Konrad Oexle, Eus J W Van Someren, Danielle Posthuma
Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits
published pages: , ISSN: 1061-4036, DOI: 10.1038/ng.3888
Nature Genetics 2019-07-08
2015 Eus J. W. Van Someren, Kim Dekker, Bart H. W. Te Lindert, Jeroen S. Benjamins, Sarah Moens, Filippo Migliorati, Emmeke Aarts, Sophie van der Sluis
The experienced temperature sensitivity and regulation survey
published pages: 59-76, ISSN: 2332-8940, DOI: 10.1080/23328940.2015.1130519
Temperature 3/1 2019-07-08
2016 Michele A. Colombo, Jennifer R. Ramautar, Yishul Wei, Germán Gomez-Herrero, Diederick Stoffers, Rick Wassing, Jeroen S. Benjamins, Enzo Tagliazucchi, Ysbrand D. van der Werf, Christian Cajochen, Eus J.W. Van Someren
Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia
published pages: 1015-1027, ISSN: 0161-8105, DOI: 10.5665/sleep.5744
SLEEP 39/05 2019-07-08
2019 Tessa F Blanken, Jeroen S Benjamins, Denny Borsboom, Jeroen K Vermunt, Casey Paquola, Jennifer Ramautar, Kim Dekker, Diederick Stoffers, Rick Wassing, Yishul Wei, Eus J W Van Someren
Insomnia disorder subtypes derived from life history and traits of affect and personality
published pages: 151-163, ISSN: 2215-0366, DOI: 10.1016/s2215-0366(18)30464-4
The Lancet Psychiatry 6/2 2019-08-30
2019 Tessa F. Blanken, Tanja Van Der Zweerde, Annemieke Van Straten, Eus J.W. Van Someren, Denny Borsboom, Jaap Lancee
Introducing Network Intervention Analysis to Investigate Sequential, Symptom-Specific Treatment Effects: A Demonstration in Co-Occurring Insomnia and Depression
published pages: 52-54, ISSN: 0033-3190, DOI: 10.1159/000495045
Psychotherapy and Psychosomatics 88/1 2019-08-30
2019 Tessa F Blanken, Eus J W van Someren
Subtyping insomnia disorder – Authors\' reply
published pages: 285-286, ISSN: 2215-0366, DOI: 10.1016/s2215-0366(19)30079-3
The Lancet Psychiatry 6/4 2019-08-30

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