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5HTCircuits SIGNED

Modulation of cortical circuits and predictive neural coding by serotonin

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EC-Contrib. €

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Project "5HTCircuits" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 2˙486˙074 €
 EC max contribution 2˙486˙074 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 2˙486˙074.00

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 Project objective

Serotonin (5-HT) is a central neuromodulator and a major target of therapeutic psychoactive drugs, but relatively little is known about how it modulates information processing in neural circuits. The theory of predictive coding postulates that the brain combines raw bottom-up sensory information with top-down information from internal models to make perceptual inferences about the world. We hypothesize, based on preliminary data and prior literature, that a role of 5-HT in this process is to report prediction errors and promote the suppression and weakening of erroneous internal models. We propose that it does this by inhibiting top-down relative to bottom-up cortical information flow. To test this hypothesis, we propose a set of experiments in mice performing olfactory perceptual tasks. Our specific aims are: (1) We will test whether 5-HT neurons encode sensory prediction errors. (2) We will test their causal role in using predictive cues to guide perceptual decisions. (3) We will characterize how 5-HT influences the encoding of sensory information by neuronal populations in the olfactory cortex and identify the underlying circuitry. (4) Finally, we will map the effects of 5-HT across the whole brain and use this information to target further causal manipulations to specific 5-HT projections. We accomplish these aims using state-of-the-art optogenetic, electrophysiological and imaging techniques (including 9.4T small-animal functional magnetic resonance imaging) as well as psychophysical tasks amenable to quantitative analysis and computational theory. Together, these experiments will tackle multiple facets of an important general computational question, bringing to bear an array of cutting-edge technologies to address with unprecedented mechanistic detail how 5-HT impacts neural coding and perceptual decision-making.

 Publications

year authors and title journal last update
List of publications.
2017 Sara Matias, Eran Lottem, Guillaume P Dugué, Zachary F Mainen
Activity patterns of serotonin neurons underlying cognitive flexibility
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.20552
eLife 6 2020-01-29
2017 Patrícia A Correia, Eran Lottem, Dhruba Banerjee, Ana S Machado, Megan R Carey, Zachary F Mainen
Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.20975
eLife 6 2020-01-29
2018 Eran Lottem, Dhruba Banerjee, Pietro Vertechi, Dario Sarra, Matthijs oude Lohuis, Zachary F. Mainen
Activation of serotonin neurons promotes active persistence in a probabilistic foraging task
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03438-y
Nature Communications 9/1 2020-01-29
2018 Kiyohito Iigaya, Madalena S. Fonseca, Masayoshi Murakami, Zachary F. Mainen, Peter Dayan
An effect of serotonergic stimulation on learning rates for rewards apparent after long intertrial intervals
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04840-2
Nature Communications 9/1 2020-01-29
2017 Patrícia Correia, Sara Matias, Zachary Mainen
Stereotaxic Adeno-associated Virus Injection and Cannula Implantation in the Dorsal Raphe Nucleus of Mice
published pages: , ISSN: 2331-8325, DOI: 10.21769/BioProtoc.2549
BIO-PROTOCOL 7/18 2020-01-29

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The information about "5HTCIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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