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BREAKBEN SIGNED

Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging

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Project "BREAKBEN" data sheet

The following table provides information about the project.

Coordinator
AALTO KORKEAKOULUSAATIO SR 

Organization address
address: OTAKAARI 1
city: ESPOO
postcode: 2150
website: http://www.aalto.fi/en/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Project website http://breakben.eu/
 Total cost 3˙998˙793 €
 EC max contribution 3˙998˙793 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-2014-2015-RIA
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AALTO KORKEAKOULUSAATIO SR FI (ESPOO) coordinator 959˙030.00
2    PHYSIKALISCH-TECHNISCHE BUNDESANSTALT DE (BRAUNSCHWEIG) participant 779˙268.00
3    Teknologian tutkimuskeskus VTT Oy FI (Espoo) participant 776˙141.00
4    TECHNISCHE UNIVERSITAET ILMENAU DE (ILMENAU) participant 442˙871.00
5    UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA IT (CHIETI) participant 440˙100.00
6    MEGIN OY FI (HELSINKI) participant 413˙735.00
7    HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ FI (HELSINKI) participant 187˙646.00

Map

 Project objective

By combining accurate magnetic measurements of neural activity with near-simultaneous high-definition measurements of cerebral structure – provided by novel methods in ultra-low-field magnetic resonance imaging (ULF MRI ) – we will be able to image the dynamics of human brain function at unprecedented resolution and reliability. BREAKBEN will achieve a revolution in neuroimaging; we aim at breaking the barrier for measurement of neuronal currents by ULF MRI (neural current imaging; NCI) as well as breaking the nonuniqueness barrier for magnetoencephalography (MEG) by combining it with ULF MRI and accurately presented a priori information. A key aspect in utilizing the a priori information is injected current density imaging (CDI), which will inform us about the individual conductivity structure of the head. Using novel verification and validation approaches, we will demonstrate the unique advantages of these multimodal techniques. These breakthroughs will result in completely different workflows in brain imaging, also suitable for clinical use. We believe that we are at the edge of a qualitative technology jump with ULF MRI, its applications and combinations. This will lead to a wealth of new applications and revolutionize the way we do magnetism-based measurements of the nervous system. Europe has the unique chance to lead this revolution.

 Deliverables

List of deliverables.
Guidelines for safety and regulatory requirements Documents, reports 2020-02-26 11:51:52
Data Management Plan Open Research Data Pilot 2020-02-26 11:51:52
External web-site Websites, patent fillings, videos etc. 2020-02-26 11:51:52
Analysis of the value of a priori information Documents, reports 2020-02-07 15:38:08
MEG-MRI on healthy subjects Demonstrators, pilots, prototypes 2020-02-07 15:38:12
Demonstration of CDI in vivo Demonstrators, pilots, prototypes 2020-02-07 15:38:10
Connectivity maps from human subject data Documents, reports 2020-02-07 15:38:11
Dissemination activities Documents, reports 2020-02-07 15:38:06

Take a look to the deliverables list in detail:  detailed list of BREAKBEN deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Eva Al-Dabbagh, Peter Hömmen, Jan-Hendrik Storm, Nora Höfner, Rainer Körber
Ultra-sensitive SQUID system for pulsed field applications
published pages: , ISSN: , DOI:
EUCAS 2017 Poster Session biennial 2020-02-26
2018 Laura Marzetti
Understanding neural synchronization by combining good practice and novel methods in electrophysiological functional connectivity analysis
published pages: , ISSN: , DOI:
19th IOP World Congress biennial 2020-02-26
2017 Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto Ilmoniemi, Gian Luca Romani, Vittorio Pizzella
Effects of MEG–MRI coregistration error on functional connectivity estimates
published pages: , ISSN: , DOI:
OHBM 2017 poster session annual 2020-02-26
2017 Mikko Luukinen
Suprajohtavan kvantti-interferenssilaitteen automatisoitu virittäminen aivokuvantamista varten [Automated tuning of a superconducting quantum interference device for brain imaging]
published pages: , ISSN: , DOI:
2020-02-26
2018 Sebastian Neuber
Konstruktion eines Gestells mit stufenlosem Manipulator der z-Achse für unterschiedliche Kryostaten innerhalb eines bestehenden Messsystems zur Probanden- und Probenmessung in magnetisch geschirmten Räumen
published pages: , ISSN: , DOI:
2020-02-26
2017 Iiro Lehto
Superconducting prepolarization coil for ultra-low-field MRI
published pages: , ISSN: , DOI:
2020-02-26
2017 Jens Haueisen, Alexander Hunold
Concept of a physical head phantom MEG-MRI and NCI/CDI
published pages: , ISSN: , DOI:
\"#brainTC\" annual 2020-02-26
2017 Alexander Hunold, Jens Haueisen
Simulated current density magnitudes and orientations for transcranial direct current stimulation montages used in depression studies
published pages: , ISSN: , DOI:
BaCI biennial 2020-02-26
2018 Alexander Hunold, Daniel Strohmeier, Patrique Fiedler, Jens Haueisen
Head phantoms for electroencephalography and transcranial electric stimulation: a skull material study
published pages: 683-689, ISSN: 0013-5585, DOI: 10.1515/bmt-2017-0069
Biomedical Engineering / Biomedizinische Technik 63/6 2020-02-26
2019 Gavriela Vranou
Assessing the value of a priori information in solving the MEG inverse problem
published pages: , ISSN: , DOI:
2020-02-26
2019 Antti J. Makinen, Koos C. J. Zevenhoven, Risto J. Ilmoniemi
Automatic Spatial Calibration of Ultra-Low-Field MRI for High-Accuracy Hybrid MEG–MRI
published pages: 1317-1327, ISSN: 0278-0062, DOI: 10.1109/tmi.2019.2905934
IEEE Transactions on Medical Imaging 38/6 2020-02-26
2018 Roberto Guidotti, Raffaele Sinibaldi, Cinzia De Luca, Allegra Conti, Risto J. Ilmoniemi, Koos C. J. Zevenhoven, Per E. Magnelind, Vittorio Pizzella, Cosimo Del Gratta, Gian Luca Romani, Stefania Della Penna
Optimized 3D co-registration of ultra-low-field and high-field magnetic resonance images
published pages: e0193890, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193890
PLOS ONE 13/3 2020-02-26
2018 Alexander Hunold, Anton Kresinsky, Berd A. Sabel, Jens Haueisen
Simulation of the current density in the retina for transorbital electric current stimulation
published pages: , ISSN: , DOI:
\"Workshop \"\"Innovative Verarbeitung bioelektrischer und biomagnetischer Signale\"\"\" biennial 2020-02-26
2017 Leif Grönberg, Mikko Kiviranta, Visa Vesterinen, Janne Lehtinen, Slawomir Simbierowicz, Juho Luomahaara, Mika Prunnila, Juha Hassel
Side-wall spacer passivated sub- μ m Josephson junction fabrication process
published pages: 125016, ISSN: 0953-2048, DOI: 10.1088/1361-6668/aa9411
Superconductor Science and Technology 30/12 2020-02-26
2018 Koos C. J. Zevenhoven, Mäkinen, Antti J., and Risto J. Ilmoniemi.
Superconducting receiver arrays for magnetic resonance imaging
published pages: , ISSN: , DOI:
2020-02-26
2018 Christoph Dinh, Lorenz Esch, Johannes Rühle, Steffen Bollmann, Daniel Güllmar, Daniel Baumgarten, Matti S. Hämäläinen, Jens Haueisen
Real-Time Clustered Multiple Signal Classification (RTC-MUSIC)
published pages: 125-128, ISSN: 0896-0267, DOI: 10.1007/s10548-017-0586-7
Brain Topography 31/1 2020-02-26
2018 Alexander Hunold, Uwe Graichen, Klaus Schellhorn, Jens Haueisen
Flexible Stimulationshaube für TES Anwendungen: Technische Parameter und Stromdichtesimulationen
published pages: , ISSN: , DOI:
62. Jahrestagung der DGKN 2018 mit Richard-Jung-Kolleg annual 2020-02-26
2017 Eva Al-Dabbagh
Hoch-sensitives SQUID-Messsystem für Anwendungen mit gepultsten Feldern
published pages: , ISSN: , DOI:
2020-02-26
2018 Alexander Hunold, Uwe Graichen, Klaus Schellhorn, Jens Haueisen
AlexandSimulated current density and technical parameters of TES applied with a flexible cap
published pages: , ISSN: , DOI:
52. Annual Conference of the German Society for Biomedical Engineering (DGBMT within VDE) annual 2020-02-26
2017 René Machts, Alexander Hunold, Jens Haueisen
Realization and Testing of a 3D Electrode Array for measuring Electric Potential Differences in a Volume Conductor
published pages: , ISSN: , DOI:
51. Jahrestagung der Biomedizinischen Technik und Dreiländertagung der Medizinischen Physik (BMTMedPhys) annual 2020-02-26
2018 Juho Luomahaara, Mikko Kiviranta, Leif Gronberg, Koos C. J. Zevenhoven, Petteri Laine
Unshielded SQUID Sensors for Ultra-Low-Field Magnetic Resonance Imaging
published pages: 1-4, ISSN: 1051-8223, DOI: 10.1109/tasc.2018.2791022
IEEE Transactions on Applied Superconductivity 28/4 2020-02-26
2016 Aino Tervo
Noise optimization of multi-layer insulation in liquid-helium cryostat for brain imaging
published pages: , ISSN: , DOI:
2020-02-26
2018 Alexander Hunold, Klaus Schellhorn, Jens Haueisen
Simulating the superposition of transcranial electric stimulations targeting the visual cortex
published pages: , ISSN: , DOI:
BIOMAG2018 biennial 2020-02-26
2019 Antea D\'Andrea, Federico Chella, Tom R. Marshall, Vittorio Pizzella, Gian Luca Romani, Ole Jensen, Laura Marzetti
Alpha and alpha-beta phase synchronization mediate the recruitment of the visuospatial attention network through the Superior Longitudinal Fasciculus
published pages: 722-732, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.12.056
NeuroImage 188 2020-02-26
2018 Paolo Capotosto, Stefania della Penna, Vittorio Pizzella, Filippo Zappasodi, Gian Luca Romani, Risto J. Ilmoniemi, Alfredo Brancucci
Theta-burst stimulation causally affects side perception in the Deutsch’s octave illusion
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31248-1
Scientific Reports 8/1 2020-02-26
2019 Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto J. Ilmoniemi, Gian Luca Romani, Vittorio Pizzella
The impact of improved MEG–MRI co-registration on MEG connectivity analysis
published pages: 354-367, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.04.061
NeuroImage 197 2020-02-26
2017 Sommariva, Sara; Sorrentino, Alberto; Piana, Michele; Pizzella, Vittorio; Marzetti, Laura
A comparative study of the robustness of frequency--domain connectivity measures to finite data length
published pages: , ISSN: 0896-0267, DOI:
Brain Topography 1 2020-02-26
2018 Alessio Basti, Vittorio Pizzella, Federico Chella, Gian Luca Romani, Guido Nolte, Laura Marzetti
Disclosing large-scale directed functional connections in MEG with the multivariate phase slope index
published pages: 161-175, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.03.004
NeuroImage 175 2020-02-26
2017 Federico Chella, Antea D\'Andrea, Alessio Basti, Vittorio Pizzella, Laura Marzetti
Non-linear Analysis of Scalp EEG by Using Bispectra: The Effect of the Reference Choice
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00262
Frontiers in Neuroscience 11 2020-02-26
2018 J-H. Storm, A. M. Cassarà, N. Höfner, P. Hömmen, E. Neufeld, R. Körber and N. Kuster
Computational and phantom-based evaluation of dc neuronal current imaging with ultra-low field magnetic resonance
published pages: , ISSN: , DOI:
Biomag 2018 Poster Session biennial 2020-02-26
2019 P. Hömmen, J.-H. Storm, N. Höfner, R. Körber
Demonstration of full tensor current density imaging using ultra-low field MRI
published pages: , ISSN: 0730-725X, DOI: 10.1016/j.mri.2019.03.010
Magnetic Resonance Imaging 2020-02-26
2018 N. Höfner, J.-H. Storm, P. Hömmen, R. Körber
Neuronal current imaging using 3D ultra-low field MRI - preliminary results
published pages: , ISSN: , DOI:
Biomag 2018 Poster Session biennial 2020-02-26
2018 P. Hömmen, J-H. Storm, N. Höfner, A. Hunold, R. Machts, J. Haueisen and R. Körber
Current Density Imaging in the Head using Ultra-Low Field Magnetic Resonance - An Advanced Phantom Study
published pages: , ISSN: , DOI:
Biomag 2018 Poster Session biennial 2020-02-26
2018 Eva Al-Dabbagh, Jan-Hendrik Storm, Rainer Korber
Ultra-sensitive SQUID Systems for Pulsed Fields—Degaussing Superconducting Pick-Up Coils
published pages: 1-5, ISSN: 1051-8223, DOI: 10.1109/TASC.2018.2797544
IEEE Transactions on Applied Superconductivity 28/4 2020-02-26
2016 Rainer Körber, Jan-Hendrik Storm, Dietmar Drung and Martin Burghoff
A modular and field tolerant ultra-low-noise multichannel SQUID system for ULF MRI and high frequency MEG
published pages: , ISSN: , DOI:
BIOMAG2016 Poster Session biennial 2020-02-26
2016 Risto Ilmoniemi, Jens Haueisen, Mikko Kiviranta, Rainer Körber, Jyrki Mäkelä, Jukka Nenonen, Gian Luca Romani, and Koos Zevenhoven
Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging: the BREAKBEN project
published pages: 409, ISSN: , DOI:
BIOMAG2016 poster/abstract biennial 2020-02-26
2016 J-H Storm, D Drung, M Burghoff, R Körber
A modular, extendible and field-tolerant multichannel vector magnetometer based on current sensor SQUIDs
published pages: 94001, ISSN: 0953-2048, DOI: 10.1088/0953-2048/29/9/094001
Superconductor Science and Technology 29/9 2020-02-26
2016 Guidotti R., Sinibaldi R., De Luca C., Conti A., Ilmoniemi R. J., Zevenhonen K. C. J., Magnelind P., Pizzella V., Romani G. L. and Della Penna S.
Optimized pipeline for the 3D co-registration of Low- and High-Field MRI
published pages: , ISSN: , DOI:
BIOMAG 2016 Poster session biannual 2020-02-26
2016 Nora Höfner and Rainer Körber and Marting Burghoff
Towards direct neuronal current imaging via ultra-low-field MR
published pages: , ISSN: , DOI:
Proceedings of the workshop Biosignal Processing 2016 2020-02-26
2016 Koos C. J. Zevenhoven and Risto J. Ilmoniemi
Recent advances in ultra-low-field MRI and its compatibility with other modalities
published pages: 410, ISSN: , DOI:
BIOMAG2016 poster/abstract biennial 2020-02-26
2016 Corinna Horn, Alexander Hunold, Jens Haueisen, Michael Funke
Comparison of dipole localization to interictal spikesin individual and standardized BEM upon three different age group
published pages: , ISSN: , DOI:
BIOMAG2016 Poster Session biennial 2020-02-26
2016 Rainer Körber, Jan-Hendrik Storm, Hugh Seton, Jyrki P Mäkelä, Ritva Paetau, Lauri Parkkonen, Christoph Pfeiffer, Bushra Riaz, Justin F Schneiderman, Hui Dong, Seong-min Hwang, Lixing You, Ben Inglis, John Clarke, Michelle A Espy, Risto J Ilmoniemi, Per E Magnelind, Andrei N Matlashov, Jaakko O Nieminen, Petr L Volegov, Koos C J Zevenhoven, Nora Höfner, Martin Burghoff, Keiji Enpuku, S Y Yang, Jen-Jei Chieh, Jukka Knuutila, Petteri Laine, Jukka Nenonen
SQUIDs in biomagnetism: a roadmap towards improved healthcare
published pages: 113001, ISSN: 0953-2048, DOI: 10.1088/0953-2048/29/11/113001
Superconductor Science and Technology 29/11 2020-02-26
2016 Alexander Hunold, Stephan Lau, Yoshio Okada, Christos Papadelis, Jens Haueisen
Calcified cortical tubers influence single dipole source localization
published pages: , ISSN: , DOI:
BIOMAG2016 Poster Session biennial 2020-02-26
2017 Rainer Körber
Ultra-sensitive SQUID instrumentation for MEG and NCI by ULF MRI
published pages: 795-798, ISSN: , DOI: 10.1007/978-981-10-5122-7_199
EMBEC & NBC 2017, IFMBE Proceedings 65 2020-02-26
2016 Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Guido Nolte, Laura Marzetti
Bispectral pairwise interacting source analysis for identifying systems of cross-frequency interacting brain sources from electroencephalographic or magnetoencephalographic signals
published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.93.052420
Physical Review E 93/5 2020-02-26
2016 Aino E Tervo, Antti J Mäkinen, Risto J Ilmoniemi, and Koos C J Zevenhoven
Accurate mapping of magnetic fields generated by an ultra-low-field MRI device
published pages: 407, ISSN: , DOI:
BIOMAG2016 poster/abstract biennial 2020-02-26
2016 Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Guido Nolte, Laura Marzetti
Identifying pairwise interacting sources from the antisymmetric cross-bispectrum of EEG/MEG data
published pages: , ISSN: , DOI:
OHBM 2016 Poster session annual 2020-02-26
2016 Yi-Cheng Hsu, Koos C.J. Zevenhoven, Ying-Hua Chu, Juhani Dabek, Risto J. Ilmoniemi, Fa-Hsuan Lin
Rotary scanning acquisition in ultra-low-field MRI
published pages: 2255-2264, ISSN: 0740-3194, DOI: 10.1002/mrm.25676
Magnetic Resonance in Medicine 75/6 2020-02-26
2016 Nora Höfner, Rainer Körber, Jens Haueisen, Peter Hömmen and Martin Burghoff
Neuronal current imaging (NCI) by Ultra-Low-Field MRI
published pages: , ISSN: , DOI:
BIOMAG2016 Poster Session biennial 2020-02-26
2017 Jan-Hendrik Storm, Peter Hömmen, Diemtar Drung, Rainer Körber
An ultra-sensitive and wideband magnetometer based on a superconductingquantum interference devic
published pages: 072603-1 - 07260, ISSN: 0003-6951, DOI: 10.1063/1.4976823
Applied Physics Letters weekly 2020-02-26
2016 Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Laura Marzetti
Impact of the reference choice on scalp EEG connectivity estimation
published pages: 36016, ISSN: 1741-2560, DOI: 10.1088/1741-2560/13/3/036016
Journal of Neural Engineering 13/3 2020-02-26
2016 Antti J. Mäkinen, Koos C. J. Zevenhoven, and Risto J. Ilmoniemi
Eliminating co-registration in MEG–MRI: automatic nonlinear calibration of ULF MRI
published pages: 406, ISSN: , DOI:
Biomag2016 poster/abstract biennial 2020-02-26

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