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ImMoRiSt

Immune Monitoring for RIsk STratification in Solid Organ Transplant Recipients

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ImMoRiSt project word cloud

Explore the words cloud of the ImMoRiSt project. It provides you a very rough idea of what is the project "ImMoRiSt" about.

transplant    immunosuppressive    competitor    quantitative    feasibility    final    cells    stimulate    immune    physicians    strength    freedom    place    global    frequency    blood    biomarker    validation    mediated    links    proprietary    highest    pursued    improves    regulatory    cell    detection    yield    ifn    provides    transplantation    obtain    firm    monitoring    heart    germany    drugs    gamma    functional    liver    performed    obtaining    austria    strategy    outcome    switzerland    release    ivd    suited    selectively    plan    patient    parallel    solid    logical    interferon    complications    uses    explore    diagnostic    marking    right    organ    scan    market    immunomonitoring    dosage    function    transplanted    cocktail    recipients    patients    kidney    leader    clinically    24    entry    sot    qualitative    clinical    rejection    business    approval    infections    tests    centers    caused    triggered    ce    every    setting    stimulants    operate    grow    relatively    lophius    validate    lung    biosciences   

Project "ImMoRiSt" data sheet

The following table provides information about the project.

Coordinator
LOPHIUS BIOSCIENCES GMBH 

Organization address
address: AM BIOPARK 13
city: REGENSBURG
postcode: 93053
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2015
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2016-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LOPHIUS BIOSCIENCES GMBH DE (REGENSBURG) coordinator 50˙000.00

Map

 Project objective

Every year ~ 40.000 patients throughout the EU are transplanted a new kidney, lung, liver, heart or another organ. The frequency of clinical complications is relatively high because at present there are no diagnostic tests that help physicians to determine the right dosage of immunosuppressive drugs necessary to avoid both organ rejection and clinical complications caused by infections.

Lophius Biosciences GmbH has developed I-Scan, a functional immune monitoring test that within 24 h provides important information on the strength of the immune system in solid organ transplant recipients. I-Scan uses a proprietary cocktail of stimulants that selectively stimulate the clinically relevant immune cells in a patient’s blood sample. The detection of the triggered interferon γ (IFN-γ) release provides a qualitative and quantitative measurement of cell-mediated immune function.

The feasibility study performed during Phase 1 will explore issues related to both, the clinical biomarker validation study and the best market entry strategy. Several objectives are pursued in parallel and encompass: • Setting up the business plan which includes a competitor as well as a freedom-to-operate analysis and a market entry strategy. • Selection of clinical study partners and defining the design of the clinical study, best suited to yield highest clinical evidence • Obtaining regulatory approval for the planned clinical study and setting a strategy to obtain regulatory approval / CE-Marking for final I-Scan products.

Lophius will apply for Phase 2 funding of a clinical study to validate that I-Scan improves the outcome of SOT patients. This study is likely to take place in Germany, Switzerland and Austria where Lophius has already established firm links to transplantation centers. The study is the logical next step to further grow Lophius to become a global leader in the IVD market for immunomonitoring

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The information about "IMMORIST" are provided by the European Opendata Portal: CORDIS opendata.

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