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UM Cure 2020 SIGNED

New therapies for uveal melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UM Cure 2020 project word cloud

Explore the words cloud of the UM Cure 2020 project. It provides you a very rough idea of what is the project "UM Cure 2020" about.

primary    2020    cure    preclinical    genetic    um    validate    network    metastatic    patient    therapies    tumour    clinical    characterisation    disease    metastases   

Project "UM Cure 2020" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 7˙971˙101 €
 EC max contribution 6˙183˙456 € (78%)
 Programme 1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme /RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 1˙659˙000.00
2    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 1˙021˙540.00
3    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 993˙956.00
4    PAMGENE INTERNATIONAL BV NL (DEN HAAG) participant 469˙625.00
5    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 434˙376.00
6    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 358˙604.00
7    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 304˙187.00
8    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) participant 248˙750.00
9    SEEDING SCIENCE FR (PARIS) participant 216˙875.00
10    UNIWERSYTET JAGIELLONSKI PL (Kraków) participant 213˙792.00
11    PEP THERAPY FR (EVRY) participant 191˙500.00
12    MELANOMA PATIENT NETWORK EUROPE SE (UPPSALA) participant 61˙250.00
13    KARLSRUHER INSTITUT FUER TECHNOLOGIE DE (KARLSRUHE) participant 10˙000.00

Mappa

 Project objective

Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or treat UM metastases. In UM Cure 2020, we aim to identify and validate at the preclinical level novel therapeutic approaches for the treatment of UM metastases. For this purpose, the consortium brings together the major experts of UM in both patient care and basic/translational/clinical research, as well as patient representatives. An ambitious multidisciplinary approach is proposed to move from patient tissue characterisation to preclinical evaluation of single or combinations of drugs. This approach includes the characterisation of the genetic landscape of metastatic UM and its microenvironment, proteomic studies to address signal pathway deregulation and establishment of novel relevant in vitro and in vivo UM models. We also aim to validate accurate surrogate endpoint biomarkers to evaluate therapies and detect metastases as early as possible. Underpinning this will be the UM Cure 2020 virtual biobank registry, linking existing biobanks into a harmonised network, which will prospectively collect primary and metastatic UM samples. Together, our approach will lead to the identification of new therapies, allowing the initiation of UM-dedicated clinical trials sponsored by academia or pharma. Dissemination of results will include the building of a patient network across the countries as part of the consortium as well as a dedicated UM patient and caregiver’s data portal as part of the UM Cure 2020 website, in order to increase patient information and disease awareness.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "UM CURE 2020" are provided by the European Opendata Portal: CORDIS opendata.

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