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UM Cure 2020 SIGNED

New therapies for uveal melanoma

Total Cost €


EC-Contrib. €






Project "UM Cure 2020" data sheet

The following table provides information about the project.


Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 7˙971˙101 €
 EC max contribution 6˙183˙456 € (78%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 1˙659˙000.00
2    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 1˙021˙540.00
4    PAMGENE INTERNATIONAL BV NL (DEN HAAG) participant 469˙625.00
5    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 434˙376.00
6    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 358˙604.00
7    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 304˙187.00
9    SEEDING SCIENCE FR (PARIS) participant 216˙875.00
10    UNIWERSYTET JAGIELLONSKI PL (KRAKOW) participant 213˙792.00
11    PEP THERAPY FR (EVRY) participant 191˙500.00


 Project objective

Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or treat UM metastases. In UM Cure 2020, we aim to identify and validate at the preclinical level novel therapeutic approaches for the treatment of UM metastases. For this purpose, the consortium brings together the major experts of UM in both patient care and basic/translational/clinical research, as well as patient representatives. An ambitious multidisciplinary approach is proposed to move from patient tissue characterisation to preclinical evaluation of single or combinations of drugs. This approach includes the characterisation of the genetic landscape of metastatic UM and its microenvironment, proteomic studies to address signal pathway deregulation and establishment of novel relevant in vitro and in vivo UM models. We also aim to validate accurate surrogate endpoint biomarkers to evaluate therapies and detect metastases as early as possible. Underpinning this will be the UM Cure 2020 virtual biobank registry, linking existing biobanks into a harmonised network, which will prospectively collect primary and metastatic UM samples. Together, our approach will lead to the identification of new therapies, allowing the initiation of UM-dedicated clinical trials sponsored by academia or pharma. Dissemination of results will include the building of a patient network across the countries as part of the consortium as well as a dedicated UM patient and caregiver’s data portal as part of the UM Cure 2020 website, in order to increase patient information and disease awareness.


List of deliverables.
Status of prospective collection and use of collected biosamples Documents, reports 2020-01-30 08:51:53
Release of main UM Cure 2020 communication tools Documents, reports 2020-01-30 08:51:53
Kick-off meeting Documents, reports 2020-01-30 08:51:53
Agreement on minimum dataset for all currently banked UM biosamples Documents, reports 2020-01-30 08:51:53

Take a look to the deliverables list in detail:  detailed list of UM Cure 2020 deliverables.


year authors and title journal last update
List of publications.
2020 Didier Decaudin, Estelle Frisch Dit Leitz, Fariba Nemati, Malcy Tarin, Adnan Naguez, Mohamed Zerara, Benjamin Marande, Raquel Vivet-Noguer, Ensar Halilovic, Claire Fabre, Aart Jochemsen, Sergio Roman-Roman, Samar Alsafadi
Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma
published pages: 93-103, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2019.12.012
European Journal of Cancer 126 2020-02-04
2019 Francesca Precazzini, Michael Pancher, Pamela Gatto, Ada Tushe, Valentina Adami, Viviana Anelli, Maria Caterina Mione
Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2019.04.005
Developmental Biology 2020-01-30
2019 Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager
Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma
published pages: 1102, ISSN: 2072-6694, DOI: 10.3390/cancers11081102
Cancers 11/8 2020-01-30
2019 Christiaan van Weeghel, Annemijn P. A. Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A. van der Velden, Wilma G. M. Kroes, Ulrich Pfeffer, Gregorius P. M. Luyten, Martine J. Jager
Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma?
published pages: 1127, ISSN: 2072-6694, DOI: 10.3390/cancers11081127
Cancers 11/8 2020-01-30
2019 Souri, Wierenga, Mulder, Jochemsen, Jager
HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target
published pages: 1132, ISSN: 2072-6694, DOI: 10.3390/cancers11081132
Cancers 11/8 2020-01-30
2019 Mehmet Dogrusöz, Andrea Ruschel Trasel, Jinfeng Cao, Selҫuk Ҫolak, Sake I. van Pelt, Wilma G. M. Kroes, Amina F. A. S. Teunisse, Samar Alsafadi, Sjoerd G. van Duinen, Gregorius P. M. Luyten, Pieter A. van der Velden, Adriana Amaro, Ulrich Pfeffer, Aart G. Jochemsen, Martine J. Jager
Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma
published pages: 1104, ISSN: 2072-6694, DOI: 10.3390/cancers11081104
Cancers 11/8 2020-01-30
2019 Annemijn P. A. Wierenga, Gülçin Gezgin, Els van Beelen, Michael Eikmans, Marijke Spruyt-Gerritse, Niels J. Brouwer, Mieke Versluis, Robert M. Verdijk, Sjoerd G. van Duinen, Marina Marinkovic, Gregorius P. M. Luyten, Martine J. Jager
Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics
published pages: 1202, ISSN: 2072-6694, DOI: 10.3390/cancers11081202
Cancers 11/8 2020-01-30
2019 Niels J. Brouwer, Gülçin Gezgin, Annemijn P.A. Wierenga, Inge H.G. Bronkhorst, Marina Marinkovic, Gregorius P.M. Luyten, Mieke Versluis, Wilma G.M. Kroes, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager
Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution
published pages: 979, ISSN: 2072-6694, DOI: 10.3390/cancers11070979
Cancers 11/7 2020-01-30
2019 Manuel Rodrigues, Leanne de Koning, Sarah Coupland, Aart Jochemsen, Richard Marais, Marc-Henri Stern, André Valente, Raymond Barnhill, Nathalie Cassoux, Andrew Evans, Iain Galloway, Martine Jager, Ellen Kapiteijn, Bozena Romanowska-Dixon, Bettina Ryll, Sergio Roman-Roman, Sophie Piperno-Neumann
So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020
published pages: 1032, ISSN: 2072-6694, DOI: 10.3390/cancers11071032
Cancers 11/7 2020-01-30
2019 Niels J. Brouwer, Annemijn P. A. Wierenga, Gülçin Gezgin, Marina Marinkovic, Gregorius P. M. Luyten, Wilma G. M. Kroes, Mieke Versluis, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager
Ischemia Is Related to Tumour Genetics in Uveal Melanoma
published pages: 1004, ISSN: 2072-6694, DOI: 10.3390/cancers11071004
Cancers 11/7 2020-01-30
2019 Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Samar Alsafadi, Sylvain Baulande, Odette Mariani, Benjamin Marande, Khadija Ait Rais, Monique K. Van der Kooij, Ellen H.W. Kapiteijn, Sieta Gassama, Sophie Gardrat, Raymond Barnhill, Vincent Servois, Rémi Dendale, Marc Putterman, Sarah Tick, Sophie Piperno-Neumann, Nathalie Cassoux, Gaelle Pierron, Joshua J Waterfall, Sergio Roman-Roman, Pascale M
Evolutionary routes in metastatic uveal melanomas depend on MBD4 alterations.
published pages: clincanres.1215., ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-19-1215
Clinical Cancer Research 2020-01-30
2018 Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern
Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04322-5
Nature Communications 9/1 2020-01-30
2018 Mark J. de Lange, Rogier J. Nell, Rajshri N. Lalai, Mieke Versluis, Ekaterina S. Jordanova, Gre P.M. Luyten, Martine J. Jager, Sjoerd H. van der Burg, Willem H. Zoutman, Thorbald van Hall, Pieter A. van der Velden
Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma
published pages: , ISSN: 1541-7786, DOI: 10.1158/1541-7786.MCR-18-0114
Molecular Cancer Research 2020-01-30
2018 Sergio Roman-Roman, Marc-Henri Stern, Samar Alsafadi, Martine J. Jager, Mehmet Dogrusöz, Sarah E. Coupland, Maria Caterina Mione, Viviana Anelli, Francesca Precazzini, Lenha Mobuchon, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Olivier Lantz, Raymond Barnhill, Sophie Piperno-Neumann, Nathalie Cassoux, Laurence Desjardins, Gulçin Gezgin, Annemijn Wierenga, Aart J. Jochemsen, Kseniya A. Glin
UM Cure 2020: New therapies for uveal melanoma
published pages: 15-17, ISSN: 2398-7073, DOI: 10.21820/23987073.2018.2.15
Impact 2018/2 2020-01-30
2019 Leticia Dominguez-Berrocal, Erica Cirri, Xiguang Zhang, Laura Andrini, Gustavo H. Marin, Sophie Lebel-Binay, Angelita Rebollo
New Therapeutic Approach for Targeting Hippo Signalling Pathway
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41404-w
Scientific Reports 9/1 2020-01-30
2018 Ewa Podgorska, Agnieszka Drzal, Zenon Matuszak, Jan Swakon, Andrzej Slominski, Martyna Elas, Krystyna Urbanska
Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation
published pages: 2236, ISSN: 1422-0067, DOI: 10.3390/ijms19082236
International Journal of Molecular Sciences 19/8 2020-01-30

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