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In Vivo Spectral Photon Counting CT Molecular Imaging in Cardio- and Neuro-Vascular Diseases

Total Cost €


EC-Contrib. €






 SPCCT project word cloud

Explore the words cloud of the SPCCT project. It provides you a very rough idea of what is the project "SPCCT" about.

plaque    prevention    cardiovascular    discrimination    complete    sustainability    spcct    bismuth    presenting    prevented    accurately    combined    quantitative    chain    imaging    ct    rupture    validate    costly    detect    disorders    micro    mi    quantify    neurovascular    contrast    disease    energy    gold    atherosclerosis    earlier    materials    gadolinium    monitor    agent    treatment    validation    combining    heart    economic    count    rate    atoms    newly    outcomes    counting    vivo    patient    variety    angiography    diagnosis    healthcare    accessible    ray    invasive    detection    vascular    decisions    photon    technique    clinical    diagnostics    preventive    spatial    event    edge    spectral    modality    coronary    harmonization    agents    efficiency    acquisition    accurate    resolution    disability    cv    stroke    tomography    analytical    probes    smes    tool    200    inflammation    detected    evaluation    designed    acute    totally    quality    ivus    achievable    personalized    computed   

Project "SPCCT" data sheet

The following table provides information about the project.


Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
postcode: 69622

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website
 Total cost 6˙441˙663 €
 EC max contribution 6˙441˙663 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    PHILIPS MEDICAL SYSTEMS TECHNOLOGIES LTD IL (Haifa) participant 1˙505˙000.00
3    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 535˙500.00
4    Philips GmbH DE (Hamburg) participant 442˙375.00
6    VOXCAN FR (MARCY L'ETOILE) participant 392˙201.00
7    KING'S COLLEGE LONDON UK (LONDON) participant 331˙968.00
8    MATHYM FR (CHAMPAGNE-AU-MONT-D'OR) participant 269˙062.00
11    BRACCO IMAGING SPA IT (MILAN) participant 91˙250.00


 Project objective

The objective of the SPCCT project is to develop and validate a widely accessible, new quantitative and analytical in vivo imaging technology combining Spectral Photon Counting CT and contrast agents, to accurately and early detect, characterize and monitor neurovascular and cardiovascular disease. Spectral Photon Counting Computed Tomography (SPCCT) is a new imaging modality, currently in development, with a totally new type of detection chain designed to provide high count-rate capabilities while offering energy discrimination with high spatial resolution of 200µm. Based on this discrimination, SPCCT can detect and quantify accurately a large variety of atoms (including Gadolinium, Gold, Bismuth…) by using the K-edge technique. SPCCT, by a more accurate, less invasive (in comparison with IVUS and coronary angiography) and reliable evaluation of vascular inflammation will allow earlier disease diagnosis such as plaque inflammation before rupture, leading to improved clinical decisions and outcomes. This will be achievable with a high spatial resolution combined to the newly developed vascular inflammation specific contrast agent detected with high quality K-edge technique that can only be provided by a multi-spectral X-ray system. The project will therefore provide a complete tool (acquisition system and specific probes) dedicated to CV imaging. It will finally contribute to: Improved early diagnosis of atherosclerosis, prevention of acute event (MI, stroke) and personalized preventive treatment; Improved management of patient presenting with an acute CV event and clinical validation of treatment efficiency; Sustainability and harmonization of healthcare systems, as costly disorders of heart failure and stroke-related disability would be better prevented and efficiently treated; Economic growth in the EU diagnostics sector, through the development of new targeted contrast materials for SPCCT by SMEs.


List of deliverables.
Selection of the most promising nanoparticles to be used as contrast agents for SPCCT Documents, reports 2020-04-07 20:32:01
Press release 2 Other 2020-04-07 20:32:01
Ethics report on pre-clinical studies Documents, reports 2020-04-07 20:32:01
management report 1 Documents, reports 2020-04-07 20:32:01
Functionalization of the nanoparticles for targeting relevant biomarkers Documents, reports 2020-04-07 20:32:01
Preliminary exploitation strategy Documents, reports 2020-04-07 20:32:01
Mid-term open Workshop Other 2020-04-07 20:32:01
Report of results on small animals Documents, reports 2020-04-07 20:32:01
Identification of the sensitivity threshold for the preparation of SPCCT contrast agents Documents, reports 2020-04-07 20:32:01
Project website Websites, patent fillings, videos etc. 2020-04-07 20:32:01
Communication plan and dissemination strategy Documents, reports 2020-04-07 20:32:01
Comprehensive overview of current care of imaging atherosclerotic patients in four major European countries Documents, reports 2020-04-07 20:32:00
Project handbook and internal platform Documents, reports 2020-04-07 20:32:01
Press release 1 Other 2020-04-07 20:32:01

Take a look to the deliverables list in detail:  detailed list of SPCCT deliverables.


year authors and title journal last update
List of publications.
2020 Grischa Bratke, Tilman Hickethier, Daniel Bar-Ness, Alexander Christian Bunck, David Maintz, Gregor Pahn, Philippe Coulon, Salim Si-Mohamed, Philippe Douek, Monica Sigovan
Spectral Photon-Counting Computed Tomography for Coronary Stent Imaging
published pages: 61-67, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000610
Investigative Radiology 55/2 2020-04-07
2019 Isabelle Riederer, Salim Si-Mohamed, Sebastian Ehn, Daniel Bar-Ness, Peter B. Noël, Alexander A. Fingerle, Franz Pfeiffer, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer
Differentiation between blood and iodine in a bovine brain—Initial experience with Spectral Photon-Counting Computed Tomography (SPCCT)
published pages: e0212679, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0212679
PLOS ONE 14/2 2020-04-07
2018 Cyril Mory, Bruno Sixou, Salim Si-Mohamed, Loïc Boussel, Simon Rit
Comparison of five one-step reconstruction algorithms for spectral CT
published pages: 235001, ISSN: 1361-6560, DOI: 10.1088/1361-6560/aaeaf2
Physics in Medicine & Biology 63/23 2020-04-07
2018 Felix K. Kopp, Heiner Daerr, Salim Si-Mohamed, Andreas P. Sauter, Sebastian Ehn, Alexander A. Fingerle, Bernhard Brendel, Franz Pfeiffer, Ewald Roessl, Ernst J. Rummeny, Daniela Pfeiffer, Roland Proksa, Philippe Douek, Peter B. Noël
Evaluation of a preclinical photon-counting CT prototype for pulmonary imaging
published pages: 2018; 8: 17386., ISSN: 2045-2322, DOI: 10.1038/s41598-018-35888-1
Scientific Reports 8/1 2020-04-07
2019 Salim Si-Mohamed, Valérie Tatard-Leitman, Alexis Laugerette, Monica Sigovan, Daniela Pfeiffer, Ernst J. Rummeny, Philippe Coulon, Yoad Yagil, Philippe Douek, Loic Boussel, Peter B. Noël
Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44821-z
Scientific Reports 9/1 2020-04-07
2018 Johoon Kim, Daniel Bar-Ness, Salim Si-Mohamed, Philippe Coulon, Ira Blevis, Philippe Douek, David P. Cormode
Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-30570-y
Scientific Reports 8/1 2020-04-07
2019 Yuxi C. Dong, Maryam Hajfathalian, Portia S. N. Maidment, Jessica C. Hsu, Pratap C. Naha, Salim Si-Mohamed, Marine Breuilly, Johoon Kim, Peter Chhour, Philippe Douek, Harold I. Litt, David P. Cormode
Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-50332-8
Scientific Reports 9/1 2020-04-07
2019 S.A. Si-Mohamed, P.C. Douek, L. Boussel
Tomodensitométrie spectrale : de la double énergie à la multiénergie
published pages: 32-45, ISSN: 2543-3431, DOI: 10.1016/j.jidi.2018.11.004
Journal d\'imagerie diagnostique et interventionnelle 2/1 2020-04-07
2017 Daniela Muenzel, Heiner Daerr, Roland Proksa, Alexander A. Fingerle, Felix K. Kopp, Philippe Douek, Julia Herzen, Franz Pfeiffer, Ernst J. Rummeny, Peter B. Noël
Simultaneous dual-contrast multi-phase liver imaging using spectral photon-counting computed tomography: a proof-of-concept study
published pages: 2017;1(1):25., ISSN: 2509-9280, DOI: 10.1186/s41747-017-0030-5
European Radiology Experimental 1/1 2020-04-07
2019 Isabelle Riederer, Daniel Bar-Ness, Melanie A. Kimm, Salim Si-Mohamed, Peter B. Noël, Ernst J. Rummeny, Philippe Douek, Daniela Pfeiffer
Liquid Embolic Agents in Spectral X-Ray Photon-Counting Computed Tomography using Tantalum K-Edge Imaging
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41737-6
Scientific Reports 9/1 2020-04-07
2018 Salim Si-Mohamed, Arnaud Thivolet, Pierre-Emmanuel Bonnot, Daniel Bar-Ness, Vahan Képénékian, David P. Cormode, Philippe Douek, Pascal Rousset
Improved Peritoneal Cavity and Abdominal Organ Imaging Using a Biphasic Contrast Agent Protocol and Spectral Photon Counting Computed Tomography K-Edge Imaging
published pages: 629-639, ISSN: 0020-9996, DOI: 10.1097/rli.0000000000000483
Investigative Radiology 53/10 2020-04-07
2019 Niki Halttunen, Frederic Lerouge, Frederic Chaput, Marc Vandamme, Szilvia Karpati, Salim Si-Mohamed, Monica Sigovan, Loic Boussel, Emmanuel Chereul, Philippe Douek, Stephane Parola
Hybrid Nano-GdF3 contrast media allows pre-clinical in vivo element-specific K-edge imaging and quantification
published pages: Sci Rep 9, 12090, ISSN: 2045-2322, DOI: 10.1038/s41598-019-48641-z
Scientific Reports 9/1 2020-04-07
2018 J F P J Abascal, N Ducros, F Peyrin
Nonlinear material decomposition using a regularized iterative scheme based on the Bregman distance
published pages: 124003, ISSN: 0266-5611, DOI: 10.1088/1361-6420/aae1e7
Inverse Problems 34/12 2020-04-07
2017 Anne-Claire Peultier, Ken Redekop, Emmanuel Coche, Johan L Severens
What are the images used to diagnose and assess suspected strokes?: A systematic literature review of care in four European countries
published pages: 177-189, ISSN: 1473-7167, DOI: 10.1080/14737167.2018.1429270
Expert Review of Pharmacoeconomics & Outcomes Research 18/2 2020-04-07
2018 Julia Dangelmaier, Daniel Bar-Ness, Heiner Daerr, Daniela Muenzel, Salim Si-Mohamed, Sebastian Ehn, Alexander A. Fingerle, Melanie A. Kimm, Felix K. Kopp, Loic Boussel, Ewald Roessl, Franz Pfeiffer, Ernst J. Rummeny, Roland Proksa, Philippe Douek, Peter B. Noël
Experimental feasibility of spectral photon-counting computed tomography with two contrast agents for the detection of endoleaks following endovascular aortic repair
published pages: 3318-3325, ISSN: 0938-7994, DOI: 10.1007/s00330-017-5252-7
European Radiology 28/8 2020-04-07
2018 Martina Tripepi, Federico Capuana, Eliana Gianolio, Flávio Vinicius Crizóstomo Kock, Amerigo Pagoto, Rachele Stefania, Giuseppe Digilio, Silvio Aime
Synthesis of High Relaxivity Gadolinium AAZTA Tetramers as Building Blocks for Bioconjugation
published pages: 1428-1437, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.8b00120
Bioconjugate Chemistry 29/4 2020-04-07

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