Opendata, web and dolomites


The diagnostic potential of miRNAs for early diagnosis of Systemic Sclerosis

Total Cost €


EC-Contrib. €






 MIRASYS project word cloud

Explore the words cloud of the MIRASYS project. It provides you a very rough idea of what is the project "MIRASYS" about.

business    subjects    commercialisation    manifestations    positively    complications    found    full    operate    demonstrated    strategy    off    impossible    strategic    disease    microrna    consists    expression    thoroughly    professionals    mirnas    potent    unknown    panel    consolidated    clinical    assay    grant    position    worldwide    spin    internal    team    company    systemic    commercial    onset    threatening    models    prior    ip    fibrosis    biomarkers    approximately    formulate    organs    boundaries    burden    detection    market    breakthrough    mirasys    actionable    diagnostics    correlates    feasibility    life    progression    prognostic    sclerosis    profiles    160    diagnosis    landscape    mirna    validate    monitoring    patients    proprietary    autoimmune    diagnostic    plan    science    designed    combination    poc    presented    freedom    tissue    analysed    disorder    characterised    elevated    precede    incorporate    skin    setting    stage    accelerate    investors    symptoms    erc    commercialise    ssc    connective   

Project "MIRASYS" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 149˙190 €
 EC max contribution 149˙190 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Systemic sclerosis (SSc) is a life-threatening autoimmune connective tissue disorder of unknown cause, characterised by fibrosis of the skin and internal organs. SSc affects approximately 160.000 patients worldwide and is associated with life-long burden of disease. Early detection of SSc is currently impossible as diagnosis is typically based on a combination of late-stage clinical symptoms. Current diagnostics, however, are based on late clinical manifestations. There is a need for actionable biomarkers for early-stage diagnosis and disease monitoring.

Based on proprietary ERC research specific microRNA (miRNA) profiles were found that positively correlates with clinical progression and complications of SSc. Its expression was elevated in subjects who demonstrated symptoms that can precede SSc onset by years. These findings provide strong support for the prognostic and diagnostic properties of the miRNA panel in SSc.

MIRASYS has been designed to accelerate the commercialisation of a panel of highly potent miRNAs that have breakthrough diagnostic potential in SSc. MIRASYS will be used to validate these findings by setting miRNA expression level boundaries for SSc development and to incorporate these in a diagnostic assay. MIRASYS will also assess the commercial feasibility of setting-up a dedicated spin-off company to commercialise the technology. The team has analysed the IP landscape for similar approaches for SSc and no prior art on the specific miRNAs was found. In the MIRASYS ERC PoC Grant, the team will further investigate the IP position and formulate a strong IP strategy including the steps towards full Freedom to Operate.

The MIRASYS team consists of experienced science and business professionals. The team has developed several business models which need to be assessed thoroughly through in-depth market research. The results need to be consolidated into a strong business plan that will be presented to investors and strategic investors.


year authors and title journal last update
List of publications.
2017 Marzia Rossato, Alsya J. Affandi, Soley Thordardottir, Catharina G. K. Wichers, Marta Cossu, Jasper C. A. Broen, Frederique M. Moret, Lara Bossini-Castillo, Eleni Chouri, Lenny van Bon, Femke Wolters, Wioleta Marut, Maarten van der Kroef, Sandra Silva-Cardoso, Cornelis P. J. Bekker, Harry Dolstra, Jacob M. van Laar, Javier Martin, Joel A. G. van Roon, Kris A. Reedquist, Lorenzo Beretta, Timothy R.
Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis
published pages: 1891-1902, ISSN: 2326-5191, DOI: 10.1002/art.40163
Arthritis & Rheumatology 69/9 2019-07-26

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MIRASYS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MIRASYS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RTMFRM (2019)

Room Temperature Magnetic Resonance Force Microscopy

Read More  

GWAS2FUNC (2019)

From GWAS to functional studies: Tackling the complex nature of brain disorders

Read More  

ECOLBEH (2020)

The Ecology of Collective Behaviour

Read More