Opendata, web and dolomites

IMPEDE

Immunomodulatory effects of sustained pantethine release in inflammatory diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "IMPEDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI VERONA 

Organization address
address: VIA DELL ARTIGLIERE 8
city: VERONA
postcode: 37129
website: www.univr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-PoC
 Funding Scheme ERC-POC
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2017-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI VERONA IT (VERONA) coordinator 150˙000.00

Map

 Project objective

Auto-immune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA) and inflammation-associated brain diseases including Alzheimer's disease (AD) globally make up a €45B market and cost society close to €648B. The huge number of patients with these diseases causes an enormous socioeconomic burden. Currently, MS, AD and RA affect 120M people worldwide. There is no cure for AD and treatments for autoimmune diseases are not fully effective and reducing the inflammatory component in these diseases is a key strategy. As a result of our ERC StG NEUROTRAFFICKING we found that a natural molecule, which is Coenzyme A precursor (CoAP), modulates leukocyte trafficking and has anti-inflammatory properties that are, however, limited in effectiveness due to fast breakdown in the gut. Our preliminary data demonstrate that derivatives of CoAP hydrolysis are devoid of antiinflammatory effects and that intact CoAP is required for its therapeutic effect in mouse models of MS and AD. The goal of IMPEDE is to develop a proprietary formulation of CoAP that protects it from hydrolysis and its disulphide bonds from degradation. This provides a novel and highly promising therapeutic approach for the inflammatory diseases, either for combination or stand-alone treatment. A patent application for this novel CoAP formulation has been filed. Subsequent steps will be taken in IMPEDE to generate and validate a more effective product through improved formulation and to prepare further regulatory and IP strategies, design a business strategy and perform market research. Overall, IMPEDE offers a rapid valorisation of the ERC StG grant on one hand and of the novel CoAP formulation on the other hand. It will generate a novel CoAP formulation with high therapeutic potential in autoimmune diseases and other inflammatory diseases.

 Publications

year authors and title journal last update
List of publications.
2017 Elena Zenaro, Gennj Piacentino, Gabriela Constantin
The blood-brain barrier in Alzheimer\'s disease
published pages: 41-56, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.07.007
Neurobiology of Disease 107 2019-07-22
2017 Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin
NETosis in Alzheimer’s Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00211
Frontiers in Immunology 8 2019-07-22
2016 Barbara Rossi, Gabriela Constantin
Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00506
Frontiers in Immunology 7 2019-07-22
2016 Enrica Pietronigro, Elena Zenaro, Gabriela Constantin
Imaging of Leukocyte Trafficking in Alzheimer’s Disease
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00033
Frontiers in Immunology 7 2019-07-22

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMPEDE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMPEDE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

ECOLBEH (2020)

The Ecology of Collective Behaviour

Read More  

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More