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ESA -ITN SIGNED

European Sepsis Academy: towards new biomarkers to improve sepsis management

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ESA -ITN" data sheet

The following table provides information about the project.

Coordinator
AMC MEDICAL RESEARCH BV 

Organization address
address: MEIBERGDREEF 9
city: AMSTERDAM ZUIDOOST
postcode: 1105AZ
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://europeansepsisacademy.com/
 Total cost 3˙895˙551 €
 EC max contribution 3˙895˙551 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2015
 Funding Scheme MSCA-ITN-ETN
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AMC MEDICAL RESEARCH BV NL (AMSTERDAM ZUIDOOST) coordinator 766˙122.00
2    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 546˙575.00
3    CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH (LAUSANNE) participant 530˙453.00
4    BIOMERIEUX SA FR (Marcy l'Etoile) participant 525˙751.00
5    INSTITUT EUROPEEN D ADMINISTRATION DES AFFAIRES FR (FONTAINEBLEAU CEDEX) participant 525˙751.00
6    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) participant 516˙122.00
7    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) participant 484˙773.00
8    ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 0.00

Map

 Project objective

ESA-ITN will break through the state of the art in sepsis diagnostics and will train 15 early-stage researchers (ESRs) to determine the clinical potency of a variety of new complementary sepsis biomarkers. These cover the full range of the antiinflammatory response in sepsis, at genetic, molecular and cellular level. Rapid and practical biomarker diagnostics for sepsis will be developed by building on some of the world's most innovative diagnostic platforms. In addition, a whole new clinical research model that incorporates use of biomarker diagnostics will be designed and tested.

All 15 interlinked ESR projects have an interdisciplinary component (intersection of sepsis research, product development, economics and medical practice) and international (representing 10 countries) and industry collaborations (incorporating 3 diagnostics firms, 1 bioinformatics company and a business school). Interactions within the network are strengthened by meaningful secondments, which take place at private beneficiary or partner institutes.

The training programme covers: 1. Specialist training in an international, interdisciplinary and intersectorial sepsis-orientated research project; 2. Advanced technology training in pathogenesis, biomarker discovery, diagnostics, trial design and innovation management; 3. Professional training in transferable skills, including the special ESA-ITN mini-MBA.

The setup of ESA-ITN is unique as it reflects the entire innovation value chain for sepsis biomarker diagnostics. ESA-ITN is composed of leading institutes in sepsis research and a selection of Europe's top biomarker diagnostics companies. Links to various global networks and shared research infrastructures in the field of sepsis further leverage the proposition of ESA-ITN.

 Deliverables

List of deliverables.
Validation of the primers and setup the Fluidigm technology for analysing MDSC Documents, reports 2020-02-25 17:07:51
First online version of network public multi modality website Websites, patent fillings, videos etc. 2020-02-25 17:07:50
Technology set up for the of DNA methylation probes of isolated cell fractions which can be used as prognostic markers in sepsis patients Documents, reports 2020-02-25 17:07:51
Validation of DNA methylation probes of isolated cell fractions Documents, reports 2020-02-25 17:07:51
Validation of the array used for whole blood leukocyte DNA analyses Documents, reports 2020-02-25 17:07:50
Report of studies with PTX3, TIR8 and IRAK-M targeted mice in murine models of sepsis Documents, reports 2020-02-25 17:07:51
Signed PCDPs Documents, reports 2020-02-25 17:07:52
Further caracterisation of MDSC subpopulations Documents, reports 2020-02-25 17:07:51

Take a look to the deliverables list in detail:  detailed list of ESA -ITN deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Aspasia Liassidou, Georgios Renieris, Dionysia‐Irene Droggiti, Theologia Gkavogianni, Christakis Liassides, Labros Sabracos, Evangelos J. Giamarellos‐Bourboulis, Charalampos S. Siristatidis
Association of modulation of pro‐inflammatory responses by dectin‐2 with preterm delivery: An experimental model
published pages: , ISSN: 1046-7408, DOI: 10.1111/aji.13216
American Journal of Reproductive Immunology 83/3 2020-04-01
2019 Amira A Bhalodi, Tjitske S R van Engelen, Harjeet S Virk, W Joost Wiersinga
Impact of antimicrobial therapy on the gut microbiome
published pages: i6-i15, ISSN: 0305-7453, DOI: 10.1093/jac/dky530
Journal of Antimicrobial Chemotherapy 74/Supplement_1 2020-04-01
2019 Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Fatemeh Asgari, Didier Le Roy, Mihai G Netea, Thierry Roger
Trained immunity confers broad-spectrum protection against bacterial infections
published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiz692
The Journal of Infectious Diseases 2020-02-25
2018 W. Joost Wiersinga, Harjeet S. Virk, Alfredo G. Torres, Bart J. Currie, Sharon J. Peacock, David A. B. Dance, Direk Limmathurotsakul
Melioidosis
published pages: 17107, ISSN: 2056-676X, DOI: 10.1038/nrdp.2017.107
Nature Reviews Disease Primers 4 2020-02-25
2018 Nora Suzanne Wolff, Floor Hugenholtz, Willem Joost Wiersinga
The emerging role of the microbiota in the ICU
published pages: , ISSN: 1364-8535, DOI: 10.1186/s13054-018-1999-8
Critical Care 22/1 2020-02-25
2017 Eleonora Ciarlo, Tytti Heinonen, Charlotte Théroude, Jacobus Herderschee, Matteo Mombelli, Jérôme Lugrin, Marc Pfefferlé, Beatrice Tyrrell, Sarah Lensch, Hans Acha-Orbea, Didier Le Roy, Johan Auwerx, Thierry Roger
Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01037
Frontiers in Immunology 8 2020-02-25
2019 Eleni Karakike, Evangelos J. Giamarellos-Bourboulis
Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00055
Frontiers in Immunology 10 2020-02-25
2019 Irene T. Schrijver, Charlotte Théroude, Thierry Roger
Myeloid-Derived Suppressor Cells in Sepsis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00327
Frontiers in Immunology 10 2020-02-25
2018 Chloé Albert-Vega, Dina M. Tawfik, Sophie Trouillet-Assant, Laurence Vachot, François Mallet, Julien Textoris
Immune Functional Assays, From Custom to Standardized Tests for Precision Medicine
published pages: 1-9, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02367
Frontiers in Immunology 9 2020-02-25
2019 Eleni Karakike, Maria-Evangelia Adami, Malvina Lada, Theologia Gkavogianni, Ioannis M. Koutelidakis, Michael Bauer, Evangelos J. Giamarellos-Bourboulis, Iraklis Tsangaris
Late Peaks of HMGB1 and Sepsis Outcome
published pages: 1, ISSN: 1073-2322, DOI: 10.1097/shk.0000000000001265
SHOCK 2020-02-25
2018 Tytti Heinonen, Eleonora Ciarlo, Charlotte Théroude, Aimilia Pelekanou, Jacobus Herderschee, Didier Le Roy, Thierry Roger
Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02675
Frontiers in Immunology 9 2020-02-25

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