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NoCut

Detection of Chromatin Bridges during Cytokinesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 NoCut project word cloud

Explore the words cloud of the NoCut project. It provides you a very rough idea of what is the project "NoCut" about.

ultra    physical    model    check    detected    constrains    aurora    parallel    dna    unprecedented    suggests    accomplished    multiple    monitors    dstorm    instability    significance    chromatin    structural    correctly    human    thereby    bridge    activation    caused    generate    cellular    signal    microscopy    basis    tumours    combining    differential    mechanisms    replication    genome    organism    site    completion    animal    final    putative    integrity    signalling    assaying    spanning    nocut    super    cytokinesis    function    made    dicentric    triggered    homologs    defects    abscission    chromosome    delaying    cell    resolution    mitosis    molecular    acting    separation    bridges    cells    condensation    components    upstream    preserving    division    mechanism    decatenation    daughter    imaging    basic    proteins    disease    composition    yeast    recognition    sensors    budding    survival    characterization    duplication    localization    binding    fine    vital   

Project "NoCut" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.crg.eu/en/programmes-groups/coordination-cytokinesis-chromosome-segregation
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

Duplication of the genome and its division into two daughter cells during mitosis is vital for survival of the organism. Cells have multiple mechanisms to ensure that this process is accomplished correctly thereby preserving the integrity of the genome. The final check before cell division is made by the NoCut abscission pathway. In yeast and animal cells, this mechanism monitors completion of chromosome separation, delaying abscission when chromosome bridges spanning the division site are detected. Aurora B is essential for NoCut function, and several of its targets in this pathway have been identified. In budding yeast, NoCut can be triggered by bridges caused by defects in chromosome condensation, decatenation and replication but importantly not by dicentric chromosome bridges. This suggests that structural features of chromatin bridges are essential to generate the NoCut signal. We will investigate the molecular basis of this differential bridge recognition and the signalling pathway acting upstream of Aurora B. We will define the composition of fine and ultra-fine chromatin bridges during cytokinesis in human cells at unprecedented resolution by super-resolution microscopy using dSTORM imaging. In parallel, we will use budding yeast to investigate the role of DNA binding proteins as sensors in the NoCut pathway. We will then establish the significance of these findings in human cells, by assaying the function of putative homologs in NoCut, and their localization in chromatin bridges by dSTORM. By combining approaches in two model systems we will define both the molecular and physical constrains for NoCut activation upstream of the established components of the NoCut pathway. Chromosome instability is associated with many human tumours and in some cases with advanced disease making the detailed characterization of this pathway relevant in our understanding of both basic cellular processes and human disease.

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The information about "NOCUT" are provided by the European Opendata Portal: CORDIS opendata.

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