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Podocyte Adaptation Proliferation and Ageing

Total Cost €


EC-Contrib. €






Project "PAPAstudy" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Project website
 Total cost 1˙479˙260 €
 EC max contribution 1˙479˙260 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE PARIS FR (PARIS) coordinator 1˙479˙260.00


 Project objective

My research project is focused on the biology of the podocyte during chronic kidney disease progression, one of the major public health challenges of the 21st Century. The podocyte is a highly specialized cell with foot processes expansion that function as vasculature-supporting cells, producing basement membrane components and a number of vascular growth factors. These cells play an essential role in renal physiology but their unique localization, as the primary filter, exposes them to many stresses in pathological conditions. In fact these cells are the direct target of many diseases such as diabetes or HIV. The molecular events and structural changes in podocyte during adaptation to nephron reduction are not well-characterized and efficient therapeutics dramatically lacking. In order to achieve the ultimate goal of improving care provided to patients suffering from renal failure, the dissection of the molecular pathways involved in podocyte adaptation and deterioration processes is mandatory. This project will combine complementary in vivo and in vitro approaches, experimental models of chronic kidney disease on genetically modified mice, as well as the use of a very innovative and new technology of bioengineering to explore the molecular and structural changes of the podocytes during kidney diseases. This work will be centralized on AKT2 and its partners, as we previously demonstrated its major role in podocyte adaptation to nephron reduction, but also on new players using unbiased approaches. In parallel and consistently with my previous works, we will systematically extend our findings to human through our unique Renal Biobank of Necker Hospital (Paris). The accomplishment of this project may lead to the discovery of novel therapeutic targets and strategies to slow down the progression of kidney disease.


year authors and title journal last update
List of publications.
2016 M. Delville, E. Baye, A. Durrbach, V. Audard, T. Kofman, L. Braun, J. Olagne, C. Nguyen, G. Deschenes, B. Moulin, M. Delahousse, G. Kesler-Roussey, S. Beaudreuil, F. Martinez, M. Rabant, P. Grimbert, M. Gallazzini, F. Terzi, C. Legendre, G. Canaud
B7-1 Blockade Does Not Improve Post-Transplant Nephrotic Syndrome Caused by Recurrent FSGS
published pages: 2520-2527, ISSN: 1046-6673, DOI: 10.1681/ASN.2015091002
Journal of the American Society of Nephrology 27/8 2020-03-20
2016 Emilie Baye, Morgan Gallazzini, Marianne Delville, Christophe Legendre, Fabiola Terzi, Guillaume Canaud
The costimulatory receptor B7-1 is not induced in injured podocytes
published pages: 1037-1044, ISSN: 0085-2538, DOI: 10.1016/j.kint.2016.06.022
Kidney International 90/5 2020-03-20
2018 Quitterie Venot, Thomas Blanc, Smail Hadj Rabia, Laureline Berteloot, Sophia Ladraa, Jean-Paul Duong, Estelle Blanc, Simon C. Johnson, Clément Hoguin, Olivia Boccara, Sabine Sarnacki, Nathalie Boddaert, Stephanie Pannier, Frank Martinez, Sato Magassa, Junna Yamaguchi, Bertrand Knebelmann, Pierre Merville, Nicolas Grenier, Dominique Joly, Valérie Cormier-Daire, Caroline Michot, Christine Bole-Feysot, Arnaud Picard, Véronique Soupre, Stanislas Lyonnet, Jeremy Sadoine, Lotfi Slimani, Catherine Chaussain, Cécile Laroche-Raynaud, Laurent Guibaud, Christine Broissand, Jeanne Amiel, Christophe Legendre, Fabiola Terzi, Guillaume Canaud
Targeted therapy in patients with PIK3CA-related overgrowth syndrome
published pages: 540-546, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0217-9
Nature 558/7711 2020-03-20
2019 Simon C. Johnson, Frank Martinez, Alessandro Bitto, Brenda Gonzalez, Cagdas Tazaerslan, Camille Cohen, Laure Delaval, José Timsit, Bertrand Knebelmann, Fabiola Terzi, Tarika Mahal, Yizhou Zhu, Philip G. Morgan, Margaret M. Sedensky, Matt Kaeberlein, Christophe Legendre, Yousin Suh, Guillaume Canaud
mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases
published pages: 455-466, ISSN: 0085-2538, DOI: 10.1016/j.kint.2018.08.038
Kidney International 95/2 2020-03-20

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